Výsledky vyhledávání

Modified Hopfinger analysis of the phosphodiesterase inhibiting activity of flavonoids

Autor: A. I. Luik, V. Yu. Tanchuk, Igor V. Tetko, G. I. Poda

Publikováno v: Theoretical and Experimental Chemistry. 29:45-50

We have obtained an effective correlation equation describing the structure dependence of the activity of a number of hydroxy- and methoxy-substituted flavonoids as cAMP phosphodiesterase inhibitors. We propose an original modification of the Hopfing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3014fae7c459efb4801c22cea109b631
https://doi.org/10.1007/bf00520261

Zobrazit plný text záznamu

Use of topological indexes for prediction of the activity of 5-lipoxygenase inhibitors in a series of hydroxamates

Autor: Igor V. Tetko, V. Yu. Tanchuk, M. I. Koshel, A. I. Luik, G. I. Poda

Publikováno v: Theoretical and Experimental Chemistry. 29:84-86

An effective system for predicting the inhibiting activity with respect to 5-lipoxygenase in a series of hydroxamic acids was developed. The bioactivity is predicted based on three selected topological indexes with one variation of the method of k-ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c65f3b6bcced44e1bb0c138995ba43
https://doi.org/10.1007/bf00530600

Zobrazit plný text záznamu

Synthesis and evaluation of 4-(N,N-diarylamino)piperidines with high selectivity to the delta-opioid receptor: a combined 3D-QSAR and ligand docking study

Autor: B L, Podlogar, G I, Poda, D A, Demeter, S P, Zhang, J R, Carson, L A, Neilson, A B, Reitz, D M, Ferguson

Publikováno v: Drug design and discovery. 17(1)

A series of 4-(N,N-diarylamino)piperidines are synthesized and evaluated for high affinity binding and selectivity to the delta-opioid receptor using a combination of 3D-QSAR and molecular docking techniques. Based on experimental ligand binding data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a4ad9ec4fa0c61a3e5656a022d6b86d
https://pubmed.ncbi.nlm.nih.gov/10928448

Zobrazit plný text záznamu

[Evolutionary programming for finding 'structure-activity' relationships in a series of 3-phenoxychromone and 3-phenoxy-4-hydroxycoumarin derivatives]

Autor: I V, Tetko, V Iu, Tanchuk, S A, Vasil'ev, V P, Khilia, G I, Poda, A I, Luĭk

Publikováno v: Bioorganicheskaia khimiia. 21(10)

Based on a set of compounds possessing hypolipidemic activity, it was demonstrated that evolutionary algorithms can be successfully used to compile an informative set of molecular parameters. The parameter sets selected using the method of potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af5adec043ae6ad23e47c96e1c07928c
https://pubmed.ncbi.nlm.nih.gov/8573213

Zobrazit plný text záznamu

Autor: I V, Radchenko, N V, Kostyuchenko, Naidenova IYu, G N, Batrak, G I, Poda, S E, Mogilevich, V K, Kibirev, A I, Luik

Publikováno v: Ukrainskii biokhimicheskii zhurnal (1. 65(5)

The effect of the synthetic thrombin substrate (TAME) and three compounds exerting an opposite effect on Ca-PPI and AdC (caffeine, atropine and meta-tolyl derivative of mechlorethamine (TDM)) on hormone-like and catalytic functions of thrombin was st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41f85124147508ec7c08d85a5359b7de
https://pubmed.ncbi.nlm.nih.gov/8160296

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání