Zobrazeno 1 - 9
of 9
pro vyhledávání: '"G I, McRae"'
Publikováno v:
LHRH and Its Analogs ISBN: 9789401089630
The search for antagonistic analogs of LHRH which could form the basis of new methods of contraception (Schally and Kastin, 1971; Guillemin, 1972) met with early successes, although the potency of these analogs was low (Monahan et al., 1972; Vale et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7f6941e09e150d239b65c5be7fb28b2
https://doi.org/10.1007/978-94-009-5588-2_11
https://doi.org/10.1007/978-94-009-5588-2_11
Inability of continuous long-term administration of D-Nal(2)6-LHRH to abolish fertility in male rats
Publikováno v:
Journal of andrology. 4(4)
A highly potent agonist of LHRH, [6-D-(2-naphthyl)-alanine]-LHRH, was administered chronically for 12 weeks to adult male rats by repetitive implantation of pellets, and its effects upon mating, fertility, and reproductive organ weights have been eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ba1bd0c598c47a5382bf9b17b8f956d
https://pubmed.ncbi.nlm.nih.gov/6225758
https://pubmed.ncbi.nlm.nih.gov/6225758
Autor:
B. H. Vickery, G. I. McRae
Publikováno v:
Journal of reproduction and fertility. 60(2)
Implantation of 25 microgram per rat of an LH-RH agonist, [Des-Gly10,D-Ala6,lProNHEt9]LH-RH, contained within a cholesterol matrix pellet caused a complete and continued suppression of oestrus in rats within 3 days. Removal of the pellets after 7 day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868c2a155889bc2d33cfa32bb9e6d867
https://pubmed.ncbi.nlm.nih.gov/7001012
https://pubmed.ncbi.nlm.nih.gov/7001012
Autor:
B. H. Vickery, G. I. McRae
Publikováno v:
LHRH and Its Analogs ISBN: 9789401089630
Following the extraction, sequencing and synthesis of LHRH, it was forecast that agonistic and antagonistic analogs would be synthesized and would warrant evaluation for profertility and antifertility uses, respectively (Schally and Kastin, 1971). Ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a1f6e02630a5c1e77e5cad6b2615770
https://doi.org/10.1007/978-94-009-5588-2_8
https://doi.org/10.1007/978-94-009-5588-2_8
Autor:
B H, Vickery, G I, McRae
Publikováno v:
International journal of fertility. 25(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::254d03ae653d8fd6865397a75e276635
https://pubmed.ncbi.nlm.nih.gov/6108925
https://pubmed.ncbi.nlm.nih.gov/6108925
Autor:
G. I. McRae, B. H. Vickery
Publikováno v:
LHRH and Its Analogs ISBN: 9789401089630
It was originally expected that LHRH and its agonist analogs would achieve therapeutic utility as pro fertility agents and conversely that antagonist analogs would find their niche as contraceptive agents (Schally and Kastin, 1971). Early findings, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e5420a3fe9a92eecd571671834b174d
https://doi.org/10.1007/978-94-009-5588-2_6
https://doi.org/10.1007/978-94-009-5588-2_6
Autor:
G. I. McRae, R. A. Simpson, Bonnie L. Horner, Ram Tahilramani, G. H. Jones, B. H. Vickery, J. J. NestorJr., Teresa L. Ho
Publikováno v:
LHRH and Its Analogs ISBN: 9789401089630
LHRH agonists with potencies greater than 200 times that of the native hormone have resulted from structure/activity studies in many laboratories (see Chapter 1; Rivier et al., 1975; Schally et al., 1981). The ability of these agents to cause desensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4636728717cdefea04a52aeaf18ead2b
https://doi.org/10.1007/978-94-009-5588-2_3
https://doi.org/10.1007/978-94-009-5588-2_3
Long-term reversible suppression of oestrus in bitches with nafarelin acetate, a potent LHRH agonist
Publikováno v:
Journal of reproduction and fertility. 74(2)
Summary. Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge. The imminent ovulation appeared to be unaffec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b908d6515b5be8a113b831dc6efe14
https://pubmed.ncbi.nlm.nih.gov/2931517
https://pubmed.ncbi.nlm.nih.gov/2931517
Publikováno v:
Journal of Steroid Biochemistry. 20:1400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7b2c77e4e932707b11ec92ff9cfe6f
https://doi.org/10.1016/0022-4731(84)90485-0
https://doi.org/10.1016/0022-4731(84)90485-0