Výsledky vyhledávání - "G I, Henderson"

Formation of malondialdehyde adducts in livers of rats exposed to ethanol: role in ethanol-mediated inhibition of cytochrome c oxidase

Autor: J, Chen, D R, Petersen, S, Schenker, G I, Henderson

Publikováno v: Alcoholism, clinical and experimental research. 24(4)

Previous studies in our laboratory demonstrated that short-term ethanol consumption by maternal rats increased the hepatic levels of 4-hydroxynonenal (HNE) in both the adult and the fetus. Additionally, HNE inhibited cytochrome c oxidase (COX) by for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dca4daf039dd9496a671450338c14c4e
https://pubmed.ncbi.nlm.nih.gov/10798592

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Histochemical method for localization of hydrogen peroxide and oxygen radicals in the intact neonatal brain

Autor: R L, Hamby-Mason, P A, Mason, S, Schenker, G I, Henderson

Publikováno v: Methods and findings in experimental and clinical pharmacology. 20(9)

The generation of reactive oxygen species has been implicated in the pathogenesis of a wide variety of diseases of the central nervous system. Often these pathological conditions involve damage to specific cell types within selected areas of the brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::007000c6aa5516d79f3e870821b1565e
https://pubmed.ncbi.nlm.nih.gov/10022027

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Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE). Role of HNE adduct formation with the enzyme subunits

Autor: J, Chen, S, Schenker, T A, Frosto, G I, Henderson

Publikováno v: Biochimica et biophysica acta. 1380(3)

The role of 4-hydroxynonenal (HNE), a major lipid peroxidation product, in oxidative damage to mitochondrial cytochrome c oxidase (COX) was examined. Oxidative stress was induced in mitochondria isolated from livers of male Sprague-Dawley rats by ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e419acae7bd0e54b5328851705b7169
https://pubmed.ncbi.nlm.nih.gov/9555085

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Maternal-to-fetal transfer of 5-methyltetrahydrofolate by the perfused human placental cotyledon: evidence for a concentrative role by placental folate receptors in fetal folate delivery

Autor: G I, Henderson, T, Perez, S, Schenker, J, Mackins, A C, Antony

Publikováno v: The Journal of laboratory and clinical medicine. 126(2)

Folates play a vital role in cellular processes that are essential for fetal growth and viability. Thus the human placenta, which contains high-affinity membrane-associated placental folate receptors (PFRs), maintains a concentrative maternal-to-feta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4965db7a4071a4efbbb7764c094bda80
https://pubmed.ncbi.nlm.nih.gov/7636392

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Effect of ethanol on rat fetal hepatocytes: studies on cell replication, lipid peroxidation and glutathione

Autor: B G, Devi, G I, Henderson, T A, Frosto, S, Schenker

Publikováno v: Hepatology (Baltimore, Md.). 18(3)

Studies have shown that ethanol at moderate concentrations inhibits epidermal growth factor-dependent replication of fetal rat hepatocytes in culture. This may account for the growth/development impairment associated with fetal alcohol syndrome and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eaeabff74fbfaa0528be9c9691e1ef25
https://pubmed.ncbi.nlm.nih.gov/8359806

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Acyclovir transport by the human placenta

Autor: G I, Henderson, Z Q, Hu, R F, Johnson, A B, Perez, Y, Yang, S, Schenker

Publikováno v: The Journal of laboratory and clinical medicine. 120(6)

Genital Herpes simplex infection is noted increasingly in women of childbearing age and in neonates. Concern about transmission of herpes to the newborn has led to cesarean delivery of many pregnant women with a history of genital herpes. Severe herp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6091a3fd3a2ec6f92185573bb25b1ab7
https://pubmed.ncbi.nlm.nih.gov/1453101

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Thiamine-transfer by human placenta: normal transport and effects of ethanol

Autor: S, Schenker, R F, Johnson, A M, Hoyumpa, G I, Henderson

Publikováno v: The Journal of laboratory and clinical medicine. 116(1)

Transport of "physiologic" concentrations of thiamine by the normal, term human placenta was studied by using the perfused cotyledon technique. Thiamine, 50 nmol/L, crossed from the maternal to fetal compartment at a rate somewhat below that of antip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b79df7ceb09dfc8c4f86beaca210b09
https://pubmed.ncbi.nlm.nih.gov/2376692

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Short-term and long-term ethanol administration inhibits the placental uptake and transport of valine in rats

Autor: R V, Patwardhan, S, Schenker, G I, Henderson, N N, Abou-Mourad, A M, Hoyumpa

Publikováno v: The Journal of laboratory and clinical medicine. 98(2)

Ethanol ingestion during pregnancy causes a pattern of fetal/neonatal dysfunction called the FAS. The effects of short- and long-term ethanol ingestion on the placental uptake and maternal-fetal transfer of valine were studied in rats. The in vivo pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3abbdd4fe9fb76f00194c60dc34b59e
https://pubmed.ncbi.nlm.nih.gov/7252333

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