Zobrazeno 1 - 10
of 20
pro vyhledávání: '"G I, Blinova"'
Publikováno v:
Cell and Tissue Biology. 14:437-447
Tumors with ocogenic Ras protein expression are hard to cure, since they are able to restore viability after treatment with antitumor agents by activating cytoprotective processes. The search for new targets for more effective therapy has shown that
Autor:
Elena Y. Kochetkova, O. A. Bystrova, Valeriy A. Pospelov, G. I. Blinova, Tatiana V. Pospelova, M. G. Martynova
Publikováno v:
Aging (Albany NY)
Autophagy is conservative catabolic process that degrades organelles, in particular, mitochondria, and misfolded proteins within the lysosomes, thus maintaining cellular viability. Despite the close relationship between mitochondrial dysfunction and
Autor:
O. A. Bystrova, Valery A. Pospelov, M. G. Martynova, Tatiana V. Pospelova, Elena Y. Kochetkova, G. I. Blinova
Publikováno v:
Aging (Albany NY)
The Ras-Raf-MEK-ERK pathway plays a central role in tumorigenesis and is a target for anticancer therapy. The successful strategy based on the activation of cell death in Ras-expressing cells is associated with the suppression of kinases involved in
Autor:
S. G. Zubova, E. Yu. Kochetkova, Pospelova Tv, T. V. Bykova, G. I. Blinova, Valery A. Pospelov
Publikováno v:
Cell and Tissue Biology. 11:268-274
Autophagy is a conserved process of protein and organelle degradation that serves to maintain cell viability. Autophagy is frequently induced in response to stress or to exposure to DNA-damaging agents or retinoids, as well as to starvation and defic
Publikováno v:
Tsitologiia. 58(12)
Autophagy is a conservative process of misfolded protein and damaged organelle degradation that serves to support cellular viability. Autophagy is often induced in response to stress, DNA damage, retinoids, starvation and growth factor withdrawal. Th
Publikováno v:
Cell and Tissue Biology. 7:245-252
The goal of this work was to study cellular mechanisms of tumor progression and metastasizing. As a result of explantation of cells of rat Zajdela ascitic hepatoma, we obtained two transplantable cell cultures—monolayer (ZH-ad) and suspension (ZH-f
Publikováno v:
Cell and Tissue Biology. 5:586-594
The goal of this work consisted in study of the immunomodulating action of the cytostatic drug cyclophosphamide (CP) on the natural cytotoxic activity of rat and mice splenocytes. The cytotoxicity of effector cells (EC) with respect to monolayer cell
Publikováno v:
Cell and Tissue Biology. 4:500-510
This work studies the mechanisms of dysdifferentiation at cell neoplastic transformation based on the example of heterogeneity of the cell populations that form malignant tumors. Two natural fractions of Zajdela rat hepatoma cells are revealed that d
Publikováno v:
Cell and Tissue Biology. 2:246-252
The study of the antigen diversion of cells of rat hepatocellular tumors, which is caused by the expression of normal antigens peculiar to renal definitive tissues (so-called “heteroorganic renal antigens”) is continued. Using an immune serum of
Publikováno v:
Tsitologiia. 55(1)
Two continuous cell lines, monolayer (ZH-ad) and suspension (ZH-fl), which doffer in the level of cell differentiation and tumorigenicity, were obtained from explants of ascitic Zajdela hepatoma. Using tumor-specific rabbit immune serum tumor-associa