Zobrazeno 1 - 10
of 1 628
pro vyhledávání: '"G Heinze"'
Autor:
David Ascheid, Magdalena Baumann, Jürgen Pinnecker, Mike Friedrich, Daniel Szi-Marton, Cornelia Medved, Maja Bundalo, Vanessa Ortmann, Asli Öztürk, Rajender Nandigama, Katherina Hemmen, Süleymann Ergün, Alma Zernecke, Matthias Hirth, Katrin G. Heinze, Erik Henke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Targeting the supportive tumor microenvironment (TME) is an approach of high interest in cancer drug development. However, assessing TME-targeted drug candidates presents a unique set of challenges. We develop a comprehensive screening platf
Externí odkaz:
https://doaj.org/article/b19449241bfb4bd295570f630d2e8595
Autor:
Till Karwen, Katarzyna Kolczynska‐Matysiak, Carina Gross, Mona C Löffler, Mike Friedrich, Angel Loza‐Valdes, Werner Schmitz, Magdalena Wit, Filip Dziaczkowski, Andrei Belykh, Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Carsten Deppermann, Sameena Nawaz, Benoit Hastoy, Agnieszka Demczuk, Manuela Erk, Mariusz R Wieckowski, Patrik Rorsman, Katrin G Heinze, David Stegner, Bernhard Nieswandt, Grzegorz Sumara
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-23 (2023)
Abstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. P
Externí odkaz:
https://doaj.org/article/974cd37e10194d4682e8df439ae20f8d
Autor:
David Ascheid, Magdalena Baumann, Caroline Funke, Julia Volz, Jürgen Pinnecker, Mike Friedrich, Marie Höhn, Rajender Nandigama, Süleyman Ergün, Bernhard Nieswandt, Katrin G. Heinze, Erik Henke
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vasculature. Successful implementat
Externí odkaz:
https://doaj.org/article/b1a63164057a41fda92985124212471c
Autor:
Ruiqi Liu, Mike Friedrich, Katherina Hemmen, Kerstin Jansen, Mateus C. Adolfi, Manfred Schartl, Katrin G. Heinze
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus, puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism
Externí odkaz:
https://doaj.org/article/e3dfc4caf3044b7580b86346898723c5
Autor:
Luise Appeltshauser, Janis Linke, Hannah S. Heil, Christine Karus, Joachim Schenk, Katherina Hemmen, Claudia Sommer, Kathrin Doppler, Katrin G. Heinze
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106139- (2023)
The node of Ranvier is the key element in saltatory conduction along myelinated axons, but its specific protein organization remains elusive in the human species. To shed light on nanoscale anatomy of the human node of Ranvier in health and disease,
Externí odkaz:
https://doaj.org/article/aad97c224a4a48d0aea422e54e0ff252
Autor:
Hannah S. Heil, Max Aigner, Sophia Maier, Prateek Gupta, Luise M.C. Evers, Vanessa Göb, Charly Kusch, Mara Meub, Bernhard Nieswandt, David Stegner, Katrin G. Heinze
Publikováno v:
Platelets, Vol 33, Iss 6, Pp 849-858 (2022)
Interrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or p
Externí odkaz:
https://doaj.org/article/7aaa438e0830455db6514ba81435dcd4
Autor:
G. Heinze
Publikováno v:
European Psychiatry, Vol 66, Pp S57-S57 (2023)
Abstract The prolongation of life expectancy has considerably increased the prevalence of chronic diseases and therefore the concomitant presence of these, this usually predicts a more reserved prognosis for both conditions and can lead to greater co
Externí odkaz:
https://doaj.org/article/1a96c496fa7d406fb73548f9ac8e059f
Autor:
Ashwin Balakrishnan, Katherina Hemmen, Susobhan Choudhury, Jan-Hagen Krohn, Kerstin Jansen, Mike Friedrich, Gerti Beliu, Markus Sauer, Martin J. Lohse, Katrin G. Heinze
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The mobility of the β2-adrenergic receptor, from the nanosecond to the second range, is revealed by combining several fluorescent spectroscopy techniques. These data also show a previously hidden mobility of this GPCR.
Externí odkaz:
https://doaj.org/article/6c035e0ba71c4bcfa54aa4a91538c748
Publikováno v:
Biophysical Reports, Vol 2, Iss 4, Pp 100079- (2022)
Efficient neuronal signaling depends on the proper assembly of the postsynaptic neurotransmitter machinery. The majority of inhibitory synapses feature γ-aminobutyric acid type A (GABAA) receptors. The function of these GABAergic synapses is control
Externí odkaz:
https://doaj.org/article/15555ec0300541b3bfa30277bd226686
Autor:
Vanessa Göb, Maximilian G. Voll, Lena Zimmermann, Katherina Hemmen, Guido Stoll, Bernhard Nieswandt, Michael K. Schuhmann, Katrin G. Heinze, David Stegner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, successful recanalization of occluded vessels is the primary therapeutic aim, but even if it is achieved, not all patients benefit. Alth
Externí odkaz:
https://doaj.org/article/9e1757261a4d4ba1a3a35180f427cda9