Zobrazeno 1 - 10
of 1 487
pro vyhledávání: '"G Hale"'
Autor:
Samira Schiefer, Benjamin G. Hale
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical to unravel key regulatory mechanisms in host antiviral defense. Here, we leverage TurboID-based proximity labeling coupled with affinity purific
Externí odkaz:
https://doaj.org/article/f88896f670a7449eae97a68b822ba5bd
Autor:
Ramona Meissner, Viktor Wixler, Franziska Paulina Wulfert, Jasmin Carina Jacob, Benjamin G. Hale, Thomas Robeck, Dörthe Masemann, Yvonne Boergeling, Stephan Ludwig
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100741- (2023)
Low pathogenic influenza A viruses (IAVs) have shown promising oncolytic potential in lung cancer–bearing mice. However, as replication-competent pathogens, they may cause side effects in immunocompromised cancer patients. To circumvent this proble
Externí odkaz:
https://doaj.org/article/e049391d1543496e91f84abf9feb0076
Autor:
Nina K. Mair, Benjamin G. Hale
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The human type I interferon (IFN) system is central to innate immune defense, and is essential to protect individuals against severe viral disease. Consequently, genetic disruption of IFN signaling or effector mechanisms is extremely rare, a
Externí odkaz:
https://doaj.org/article/a3ddbe34b68c4d8e8aaae1874444d665
Autor:
Sonja Fernbach, Benjamin G. Hale
Publikováno v:
PLoS Biology, Vol 20, Iss 9 (2022)
Writing in PLOS Biology, Ching and colleagues show that ACE2-decorated exosomes are deployed as natural inhibitory decoys against SARS-CoV-2. High decoy levels correlate with improved patient outcomes, suggesting they directly help COVID-19 recovery
Externí odkaz:
https://doaj.org/article/8c0c61e10afa46548b752d8ca83fb948
Autor:
Idoia Busnadiego, Irene A Abela, Pascal M Frey, Daniel A Hofmaenner, Thomas C Scheier, Reto A Schuepbach, Philipp K Buehler, Silvio D Brugger, Benjamin G Hale
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001709 (2022)
Autoantibodies neutralizing the antiviral action of type I interferons (IFNs) have been associated with predisposition to severe Coronavirus Disease 2019 (COVID-19). Here, we screened for such autoantibodies in 103 critically ill COVID-19 patients in
Externí odkaz:
https://doaj.org/article/b3408de1604843568c24aa541f6d426c
Autor:
Sonja Fernbach, Eva E. Spieler, Idoia Busnadiego, Umut Karakus, Anouk Lkharrazi, Silke Stertz, Benjamin G. Hale
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110549- (2022)
Summary: Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain uncharacterized. Here, using RNAi screening, we identify several ISG restriction factors with
Externí odkaz:
https://doaj.org/article/c7fe089cf64945cbabb2229136207bb2
Autor:
Liliana Echavarría-Consuegra, Georgia M Cook, Idoia Busnadiego, Charlotte Lefèvre, Sarah Keep, Katherine Brown, Nicole Doyle, Giulia Dowgier, Krzysztof Franaszek, Nathan A Moore, Stuart G Siddell, Erica Bickerton, Benjamin G Hale, Andrew E Firth, Ian Brierley, Nerea Irigoyen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009644 (2021)
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosom
Externí odkaz:
https://doaj.org/article/eaf77300e108401e93e7f0b5b3c8dc13
Autor:
Benjamin G Hale
Publikováno v:
eLife, Vol 10 (2021)
When culturing SARS-CoV-2 in the laboratory it is vital to avoid deletions in the gene for the spike protein that could affect the interpretation of experiments.
Externí odkaz:
https://doaj.org/article/f1350bbfa0374754b648cf2be383ef1e
Autor:
Patricia Domingues, Davide Eletto, Carsten Magnus, Hannah L. Turkington, Stefan Schmutz, Osvaldo Zagordi, Matthias Lenk, Martin Beer, Silke Stertz, Benjamin G. Hale
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Polymorphisms in the avian influenza A virus (IAV) polymerase restrict its host range during transmission from birds to mammals. Here, the authors investigate differences in the host chromatin regulator ANP32A regarding IAV polymerase adaptation, and
Externí odkaz:
https://doaj.org/article/c571427377a442969ca7292bcf2a560b
Autor:
Marie O Pohl, Idoia Busnadiego, Verena Kufner, Irina Glas, Umut Karakus, Stefan Schmutz, Maryam Zaheri, Irene Abela, Alexandra Trkola, Michael Huber, Silke Stertz, Benjamin G Hale
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001006 (2021)
Since entering the human population, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; the causative agent of Coronavirus Disease 2019 [COVID-19]) has spread worldwide, causing >100 million infections and >2 million deaths. While large-sca
Externí odkaz:
https://doaj.org/article/942eb63eba2e43ccbc2ad9759b98db2c