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Akademický článek

Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains

Autor: Stefano Marullo, Mark G. H. Scott, Hervé Enslen, Mathieu Coureuil

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

More than 12 years have passed since the seminal observation that meningococcus, a pathogen causing epidemic meningitis in humans, occasionally associated with infectious vasculitis and septic shock, can promote the translocation of β-arrestins to t

Externí odkaz: https://doaj.org/article/629dc2d8f3c5418c913fe97e5ace516d

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Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites

Autor: Kusumika Saha, Benoit Chevalier, Stéphane Doly, Nesrine Baatallah, Thomas Guilbert, Iwona Pranke, Mark G. H. Scott, Hervé Enslen, Chiara Guerrera, Cérina Chuon, Aleksander Edelman, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter, Stefano Marullo

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2022, 79 (10), pp.530. ⟨10.1007/s00018-022-04554-1⟩

International audience; The endoplasmic reticulum exit of some polytopic plasma membrane proteins (PMPs) is controlled by arginin-based retention motifs. PRAF2, a gatekeeper which recognizes these motifs, was shown to retain the GABAB-receptor GB1 su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860c69fcace1bffc2d5764e5cf85f183
https://hal.science/hal-03783229/document

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Akademický článek

Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control.

Autor: Anahi Molla-Herman, Cedric Boularan, Rania Ghossoub, Mark G H Scott, Anne Burtey, Marion Zarka, Sophie Saunier, Jean-Paul Concordet, Stefano Marullo, Alexandre Benmerah

Publikováno v: PLoS ONE, Vol 3, Iss 11, p e3728 (2008)

The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls important physiological processes. Specific sets of membrane proteins involved in sensing t

Externí odkaz: https://doaj.org/article/72b14ec71a724745af620aacb017bbdc

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Mechanical GPCR Activation by Traction Forces Exerted on Receptor

Autor: Stefano, Marullo, Stephane, Doly, Kusumika, Saha, Hervé, Enslen, Mark G H, Scott, Mathieu, Coureuil

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] Cells are sensitive to chemical stimulation which is converted into intracellular biochemical signals by the activation of specific receptors. Mechanical stimulations can also induce biochemical responses via the activation of vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d6dc463c9086ba6fba158f2c1657060
https://pubmed.ncbi.nlm.nih.gov/32296760

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β-Arrestins: Multitask Scaffolds Orchestrating the Where and When in Cell Signalling

Autor: Stéphane A, Laporte, Mark G H, Scott

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1957

The β-arrestins (β-arrs) were initially appreciated for the roles they play in the desensitization and endocytosis of G protein-coupled receptors (GPCRs). They are now also known to act as multifunctional adaptor proteins binding many non-receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4269c1f24839746b9862c9ffa419a1e3
https://pubmed.ncbi.nlm.nih.gov/30919345

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Methods to Investigate the Nucleocytoplasmic Shuttling Properties of β-Arrestins

Autor: Elodie, Blondel-Tepaz, Thomas, Guilbert, Mark G H, Scott

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1957

β-Arrestins (β-arrs) were originally appreciated for the roles they play in the desensitization and internalization of G protein-coupled receptors (GPCRs). They are also now known to act as molecular scaffolds, providing control in multiple signall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4d113b37349ef9378714b7d1574a335
https://pubmed.ncbi.nlm.nih.gov/30919359

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Targeting PTEN in Colorectal Cancers

Autor: Larissa, Kotelevets, Mark G H, Scott, Eric, Chastre

Publikováno v: Advances in experimental medicine and biology. 1110

Phosphatase and tensin homolog (PTEN) is a tumour suppressor that represents one of the most common targets for genetic defect in human cancer. PTEN controls an array of physiopathological processes related to cell proliferation, differentiation, DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be7bfc9b5d96617115f1a5abdf20a6a7
https://pubmed.ncbi.nlm.nih.gov/30623366

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Targeting PTEN in Colorectal Cancers

Autor: Larissa Kotelevets, Mark G. H. Scott, Eric Chastre

Publikováno v: Targeted Therapy of Colorectal Cancer Subtypes
Targeted Therapy of Colorectal Cancer Subtypes, pp.55-73, 2018, ⟨10.1007/978-3-030-02771-1_5⟩
Targeted Therapy of Colorectal Cancer Subtypes ISBN: 9783030027704

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58d858d5520a6e5de2fcd0b5cab4d0a
https://hal.archives-ouvertes.fr/hal-02349103

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