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Effects of vanadium (sodium metavanadate) and aflatoxin-B1 on cytochrome p450 activities, DNA damage and DNA methylation in human liver cell lines

Autor: C. Cummings-Lorbetskie, Karen Leingartner, G. H. Xiao, Craig Parfett, Daniel Desaulniers, Gu Zhou

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 70

Vanadium is considered as "possibly carcinogenic to humans" (V2O5, IARC Group 2B), yet uncertainties persist related to the toxicity mechanisms of the multiple forms of vanadium. Exposure to vanadium often co-occurs with other metals or with organic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8126f7bf7eb2cf0e2575c9b93e26f0
https://pubmed.ncbi.nlm.nih.gov/33164849

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Akademický článek

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Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats

Autor: Daniel Desaulniers, C. Cummings-Lorbetskie, Khan N, Andrew Williams, G. H. Xiao, Carole L. Yauk, Karen Leingartner

The notion that adverse health effects produced by exposure to environmental contaminants (EC) may be modulated by the presence of non-chemical stressors is gaining attention. Previously, our lab demonstrated that cross-fostering (adoption of a litte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f738345e70f125f647ea0815d45276

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Akademický článek

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Effects of lactational and/or in utero exposure to environmental contaminants on the glucocorticoid stress-response and DNA methylation of the glucocorticoid receptor promoter in male rats

Autor: G. H. Xiao, Desaulniers D, Cummings-Lorbetskie C

Publikováno v: Toxicology. 308:20-33

Perinatal events can reprogram the hypothalamo-pituitary-adrenal axis for the entire lifespan leading to abnormal glucocorticoid stress-response (GSR) in adulthood: a phenomenon reported to be mediated by changes in DNA methylation of the glucocortic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7afc5f6a73056120d14e13556837014
https://doi.org/10.1016/j.tox.2013.03.006

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Sodium bisulfite pyrosequencing revealed that developmental exposure to environmental contaminant mixtures does not affect DNA methylation of DNA repeats in Sprague-Dawley rats

Autor: Daniel Desaulniers, G. H. Xiao, C. Cummings-Lorbetskie, Nanqin Li, Karen Leingartner, Leonora Marro, Nasrin Khan

Publikováno v: Journal of toxicology and environmental health. Part A. 80(1)

Hypomethylation of DNA repeats has been linked to diseases and cancer predisposition. Human studies suggest that higher blood concentrations of environmental contaminants (EC) correlate with levels of hypomethylation of DNA repeats in blood. The obje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fc3a0bfdd6b274af17608c60d65968
https://pubmed.ncbi.nlm.nih.gov/27905861

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Two-color fluorescent cytosine extension assay for the determination of global DNA methylation

Autor: G. H. Xiao, Daniel Desaulniers, Gu Zhou, C. Cummings-Lorbetskie, Craig Parfett

Publikováno v: BioTechniques. 62(4)

Here, we present a DNA restriction enzyme–based, fluorescent cytosine extension assay (CEA) to improve normalization and technical variation among sample-to-sample measurements. The assay includes end-labeling of parallel methylation-sensitive and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68362db5ba6cb9780f77f4fdf61b24cd
https://pubmed.ncbi.nlm.nih.gov/28403806

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Effects of Developmental Exposure to Mixtures of Environmental Contaminants on the Hepatic Metabolism of Estradiol-17β in Immature Female Sprague Dawley Rats

Autor: Karen Leingartner, Daniel Desaulniers, Wayne J. Bowers, Guillaume Pelletier, G. H. Xiao

Publikováno v: International Journal of Toxicology. 31:454-466

Exposure to environmental contaminants induces the activation of cytochrome P450s (CYP) which lead to the hydroxylation of contaminants and endogenous hormones such as estrogens. The hydroxylation of estrogens forms catecholestrogens (CEs), one of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107e547a6e04331b9ac6a39a5ce0d965
https://doi.org/10.1177/1091581812457431

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Effects of Mixtures of Polychlorinated Biphenyls, Methylmercury, and Organochlorine Pesticides on Hepatic DNA Methylation in Prepubertal Female Sprague-Dawley Rats

Autor: Wayne J. Bowers, Daniel Desaulniers, G. H. Xiao, Jiping Zhu, Hong Lian, Jamie Nakai, Yong-Lai Feng

Publikováno v: International Journal of Toxicology. 28:294-307

DNA methylation is one of the epigenetic mechanisms that regulates gene expression, chromosome structure, and stability. Our objective was to determine whether the DNA methylation system could be a target following in utero and postnatal exposure to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642fbc9d8202fbb2901995013d9861ec
https://doi.org/10.1177/1091581809337918

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