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In vitro responses of caudal hypothalamic neurons to hypoxia and hypercapnia

Publikováno v: Neuroscience. 51:941-950

Results from previous studies have suggested that the hypothalamus modulates cardiorespiratory responses to hypoxia and/or hypercapnia. Many neurons in the caudal hypothalamus are stimulated by hypercapnia and hypoxia in vivo ; however, it is not kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e6c8b117247e3f8991e3db2068eec4
https://doi.org/10.1016/0306-4522(92)90531-6

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Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action

Autor: R Q, Huang, C L, Bell-Horner, M I, Dibas, D F, Covey, J A, Drewe, G H, Dillon

Publikováno v: The Journal of pharmacology and experimental therapeutics. 298(3)

Pentylenetetrazole (PTZ) is a central nervous system convulsant that is thought, based on binding studies, to act at the picrotoxin (PTX) site of the gamma-aminobutyric acid type A (GABA(A)) receptor. In the present study, we have investigated the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae4bb52464f877135299c8c2509da63b
https://pubmed.ncbi.nlm.nih.gov/11504794

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Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin

Autor: R Q, Huang, G H, Dillon

Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(1)

In the present study, rundown of gamma-aminobutyric acid (GABA)-activated Cl- channels was studied in recombinant GABAA receptors stably expressed in human embryonic kidney cells (HEK 293), with conventional whole-cell and amphotericin B-perforated p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0104f200a4f93cca80f30a1ed7ebc625
https://pubmed.ncbi.nlm.nih.gov/9655866

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Chloride channel expression with the tandem construct of alpha 6-beta 2 GABAA receptor subunit requires a monomeric subunit of alpha 6 or gamma 2

Autor: W B, Im, J F, Pregenzer, J A, Binder, G H, Dillon, G L, Alberts

Publikováno v: The Journal of biological chemistry. 270(44)

Despite the presence of the multiple subunits (alpha, beta, gamma, and delta) and their isoforms for gamma-aminobutyric acid, type A (GABAA) receptors in mammalian brains, the alpha x beta 2 gamma 2 subtypes appear to be the prototype GABAA receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a37c9fb940f05c716cadc893c62ae0e
https://pubmed.ncbi.nlm.nih.gov/7592805

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[4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability

Autor: G H, Dillon, W B, Im, J F, Pregenzer, D B, Carter, B J, Hamilton

Publikováno v: The Journal of pharmacology and experimental therapeutics. 272(2)

U-93631,[4-dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline], represents a GABAA receptor ligand of novel chemical structure, and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl- currents in recombinant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3dded61de5ef8e60568a16bd4d1c721f
https://pubmed.ncbi.nlm.nih.gov/7531762

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Central Hypoxic Chemoreceptors in the Ventrolateral Medulla and Caudal Hypothalamus

Autor: P. C. Nolan, Tony G. Waldrop, G. H. Dillon

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461357926

Even though hypoxia is known to depress the activity of many central nervous system neurons (11,12,18), CNS hypoxia increases ventilation and cardiovascular drive under some experimental and clinical conditions (1,5,8). Central hypoxia elicits the ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::726ec92c69e2cb088b2642bc5e178e54
https://doi.org/10.1007/978-1-4615-1933-1_49

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Central hypoxic chemoreceptors in the ventrolateral medulla and caudal hypothalamus

Autor: P C, Nolan, G H, Dillon, T G, Waldrop

Publikováno v: Advances in experimental medicine and biology. 393

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aefa8160cb1eff28d4836ecb8ab2fd77
https://pubmed.ncbi.nlm.nih.gov/8629493

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U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors

Autor: G H, Dillon, H K, Im, B J, Hamilton, D B, Carter, R B, Gammill, T M, Judge, W B, Im

Publikováno v: Molecular pharmacology. 44(4)

We discovered the ability of U-93631 (4-dimethyl-3-t-butylcarboxyl-4,5- dihydro[1,5-a]imidazoquinoxaline) to accelerate decay of gamma-aminobutyric acid (GABA)-induced currents, and we explored its mechanism in human embryonic kidney cells (HEK-293)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf6d7140d2ec8083c23192e648a951e1
https://pubmed.ncbi.nlm.nih.gov/8232235

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Responses of feline caudal hypothalamic cardiorespiratory neurons to hypoxia and hypercapnia

Autor: G. H. Dillon, Tony G. Waldrop

Publikováno v: Experimental Brain Research. 96

Several studies have suggested that the caudal hypothalamus modulates responses to hypercapnia and hypoxia. In addition, this area of the hypothalamus contains neurons that have a sympathoexcitatory discharge. The purpose of the present study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f28fa6fea6911ff6c227263736c5da7
https://doi.org/10.1007/bf00227106

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