Zobrazeno 1 - 10
of 296
pro vyhledávání: '"G Geisler"'
Publikováno v:
Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb73a416b36dda241b92e80395f376e0
https://doi.org/10.1055/s-0043-1760795
https://doi.org/10.1055/s-0043-1760795
Autor:
John G. Geisler
Publikováno v:
Cells, Vol 8, Iss 3, p 280 (2019)
In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest
Externí odkaz:
https://doaj.org/article/eaed89b49b994b7a8180ff5629d170d4
Akademický článek
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Autor:
Dong Liu, John G. Geisler, Mark P. Mattson, William Fang, Joshua C. Johnson, Krisztina Marosi, Yuki Kishimoto, Joshua Halpern
Publikováno v:
Neurobiology of Aging. 85:123-130
Dopaminergic neuronal cell loss in the substantia nigra is responsible for the motor symptoms that are the clinical hallmark of Parkinson’s disease (PD). As of yet there are no treatments that slow or prevent the degeneration of dopaminergic neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c5ab8bb049e0085c0f39f48f4ef896
https://doi.org/10.1016/j.neurobiolaging.2019.09.011
https://doi.org/10.1016/j.neurobiolaging.2019.09.011
Autor:
Jenson Qi, Wensheng Lang, John G. Geisler, Ping Wang, Ioanna Petrounia, Selyna Mai, Charles Smith, Hossein Askari, Geoffrey T. Struble, Robyn Williams, Sanjay Bhanot, Brett P. Monia, Shariff Bayoumy, Eugene Grant, Gary W. Caldwell, Matthew J. Todd, Yin Liang, Micheal D. Gaul, Keith T. Demarest, Margery A. Connelly
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1106-1116 (2012)
Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially different physiological functions. To date, the ability to determi
Externí odkaz:
https://doaj.org/article/bd9cb90a4bc84a398c5c84be64b6a2a9
Autor:
Patrick G. Sullivan, W. Brad Hubbard, Hemendra J. Vekaria, John G. Geisler, Christopher L. Harwood
Publikováno v:
Journal of Neuroscience Research. 96:1677-1688
Traumatic brain injury (TBI) results in cognitive impairment, which can be long-lasting after moderate to severe TBI. Currently, there are no FDA-approved therapeutics to treat the devastating consequences of TBI and improve recovery. This study util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae83bec3df52ade5cd358d4089f82895
https://doi.org/10.1002/jnr.24271
https://doi.org/10.1002/jnr.24271
Autor:
Hossein B. Askari, Raymond J. Patch, Wing S. Cheung, Hui Huang, Derek A. Beauchamp, Jyotsna Kasturi, Meghan Towers, Jianying Liu, Bao-Ping Zhao, Sharmila Patel, Dionisios Rentzeperis, Micheal Gaul, Mark R. Player, Guozhang Xu, John G. Geisler
Publikováno v:
European Journal of Medicinal Chemistry. 138:830-853
Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally implicated in the regulation of energy homeostasis. Herein is described the development of indazole-based N-alkylthiazolidenediones, which function in bioch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb5c376454ed13376d112e16a0c3b4e
https://doi.org/10.1016/j.ejmech.2017.07.015
https://doi.org/10.1016/j.ejmech.2017.07.015
Autor:
Raymond J. Patch, Tianbao Lu, Hui Huang, Brian Rady, Alan Gibbs, Thomas Kirchner, Yu-Kai Lee, Carl R. Illig, Parks Daniel J, Margery A. Connelly, Sanath K. Meegalla, Mark R. Player, Wing S. Cheung, Chen Jinsheng, John G. Geisler, Hossein B. Askari, Kenneth J. Wilson, Sharmila Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4216-4222
Design and optimization of a novel series of imidazo[1,2-b]pyridazine PDE10a inhibitors are described. Compound 31 displays excellent pharmacokinetic properties and was also evaluated as an insulin secretagogue in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3782121a3497083eeb19948c8d5412
https://doi.org/10.1016/j.bmcl.2016.07.054
https://doi.org/10.1016/j.bmcl.2016.07.054
Background and Purpose-Mobile stroke units (MSUs) are known to increase the proportion of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) in the first golden hour (GH) after onset compared with hospital settings (HS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::63e8f7718ba7395c3e115f0c106112f5
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2987925
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2987925
Publikováno v:
Psychological reports. 120(5)
This study used a reversal theory framework to examine motivational dominance and changes in motivational state, arousal, stress, and emotions among members of traditional Japanese (Nihon Odori Sports Science (NOSS)) and New Zealand (Kapa Haka) dance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ace4ba311298b92def35f26ccd8827
https://pubmed.ncbi.nlm.nih.gov/28565975
https://pubmed.ncbi.nlm.nih.gov/28565975