Výsledky vyhledávání - "G G, Rusinova"

The Role of Polymorphisms of Key Genes of DNA Base Excision Repair in Terms of Lung Cancer Predisposition in 'Mayak' Workers

Autor: G G, Rusinova, N S, Vyazovskaya, T V, Azizova, S V, Osovets, I V, Glazkova, A S, Kozedub

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 56(4)

An association between polymorphic variants of key genes of base excision repair (BER) and lung cancer was studied in "Mayak" workers occupationally exposed to prolonged external y-rays and internal α-radiation from incorporated (239)Pu. The study w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa4c43ef027baa3202fe4dadd48ba97f
https://pubmed.ncbi.nlm.nih.gov/30703296

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Analysis of genome instability in offspring of Mayak workers’ families: Minisatellite CEB

Autor: N. S. Vyazovskaya, Irina Glazkova, Tamara V. Azizova, G. G. Rusinova, S. V. Osovets

Publikováno v: Russian Journal of Genetics. 50:1200-1207

Genome instability transmission in offspring was analyzed in order to evaluate the risk of delayed genetic effects of exposure in 95 family triplets in which only fathers experienced prolonged occupational radiation exposure. The mean total preconcep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e9f1c483c5cad7acf42215b4d486120
https://doi.org/10.1134/s102279541411012x

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Gene Expression Analysis in Mayak Workers With Prolonged Occupational Radiation Exposure

Autor: G. G. Rusinova, Sven Senf, N. S. Vyazovskaya, Viktor Meineke, Kerstin Müller, Kristian Unger, Michael Abend, Irina Glazkova, Helmut Kreppel, Harald Dörr, Daniel Schmidl, Tamara V. Azizova

Publikováno v: Health Physics. 106:664-676

The authors evaluated gene expression in the peripheral blood in relation to occupational exposure in Mayak workers to find out about the existence of a permanent post exposure signature. Workers were exposed to combined incorporated ²³⁹Pu and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ac326c96fde6104e576006587868ab
https://doi.org/10.1097/hp.0000000000000018

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Radiation-Induced Lung Adenocarcinoma is Associated with Increased Frequency of Genes Inactivated by Promoter Hypermethylation

Autor: Frank D. Gilliland, Frederick D. Gentry, Thomas H. March, Donna M. Klinge, Terri Kang, Christopher M. Lyon, Galina Adamova, Steven A. Belinsky, Vitaliy Telnov, G. G. Rusinova, Kieu C. Liechty

Publikováno v: Radiation Research. 168:409-414

Epigenetic inactivation of genes by promoter hypermethylation, a major mechanism in the initiation and progression of tobacco-induced cancer, has also been associated with lung cancer induced through environmental and occupational exposures. Our prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8759c9b3124a596b463f4ea361f3699e
https://doi.org/10.1667/rr0825.1

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Association of radiation-induced genes with noncancer chronic diseases in Mayak workers occupationally exposed to prolonged radiation

Autor: Helmut Kreppel, Kerstin Müller, N. S. Vyazovskaya, G. G. Rusinova, Irina Glazkova, Sven Doucha-Senf, Kristian Unger, Harald Dörr, Herbert Braselmann, Michael Abend, Viktor Meineke, Tamara V. Azizova

Publikováno v: Radiat. Res. 183, 249-261 (2015)

We examined the association of gene expression with noncancer chronic disease outcomes in Mayak nuclear weapons plant workers who were exposed to radiation due to their occupation. We conducted a cross-sectional study with selection based on radiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20f6c6737c48bd66bb07f60009f98f8
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=44008

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Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma

Autor: G. G. Rusinova, Kieu C. Liechty, Donna M. Klinge, Steven A. Belinsky, Vitaliy Telnov, Natalie Sotnic, Frank D. Gilliland, Terri Kang, Galina Adamova, Thomas H. March

Publikováno v: Carcinogenesis. 25:1063-1067

Lung cancer from radon or (239)plutonium exposure has been linked to alpha-particles that damage DNA through large deletions and point mutations. We investigated the involvement of an epigenetic mechanism, gene inactivation by promoter hypermethylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e83eb353fc81f6b7fb6004c85ed1b5f
https://doi.org/10.1093/carcin/bgh096

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Independent validation of candidate genes identified after a whole genome screening on Mayak workers exposed to prolonged occupational radiation

Autor: Kristian Unger, Helmut Kreppel, Harald Dörr, Irina Glazkova, N. S. Vyazovskaya, Michael Abend, Sven Senf, Tamara V. Azizova, Kerstin Müller, Viktor Meineke, G. G. Rusinova

Publikováno v: Radiat. Res. 182, 299-309 (2014)

We evaluated gene expression in the peripheral blood of Mayak workers in relationship to occupational chronic exposure to identify permanent post-exposure signatures. The Mayak workers had experienced either a combined exposure to incorporated (239)P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e266fc9a9083bcadd1463ee10b4ef37
https://pubmed.ncbi.nlm.nih.gov/25076116

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[Untitled]

Autor: N. D. Okladnikova, G. G. Rusinova, Dudchenko Nn, G. V. Adamova, S. V. Osovets

Publikováno v: Russian Journal of Genetics. 37:1096-1099

A DNA bank was created to preserve the genetic material of staff of the first Russian atomic plant, Production Association (PO) Mayak, who were exposed to chronic external γ-irradiation at various doses in the early years of plant operation. Some of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5abc201f3cdc7ac88009dd6a6ec082a7
https://doi.org/10.1023/a:1011982119254

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