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Akademický článek

Platelet-Rich stroma from Crohn’s disease patients for treatment of perianal fistula shows a higher myeloid cell profile compared to non-IBD controls

Autor: J.H.C. Arkenbosch, M.A.J. Becker, C.J. Buskens, C. Witjes, A.C. de Vries, C.J. van der Woude, G. Fuhler, M.E. Wildenberg, O. van Ruler

Publikováno v: Stem Cell Research, Vol 67, Iss , Pp 103039- (2023)

Background: New cell-based therapies are under investigation to improve perianal fistulizing Crohn’s disease (pCD) healing. Autologous stromal vascular fraction combined with platelet-rich plasma (referred to as platelet-rich stroma [PRS]) is a new

Externí odkaz: https://doaj.org/article/50e9a265555b4e36b5e9aebb07ffbc8d

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Bright light during wakefulness improves sleep quality in healthy men

Autor: R. Lok, T. Woelders, M. C. M. Gordijn, M. J. van Koningsveld, K. Oberman, S. G. Fuhler, D. G. M. Beersma, R. A. Hut

Publikováno v: Journal of Biological Rhythms, 37(4), 429-441. SAGE Publications Inc.

Under real-life conditions, increased light exposure during wakefulness seems associated with improved sleep quality, quantified as reduced time awake during bed time, increased time spent in non-rapid eye movement (NREM) sleep, or increased power of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f025b82eb783782d7c5af419e8f54d3
https://doi.org/10.1177/07487304221096910

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Bright light decreases peripheral skin temperature in healthy men

Autor: R. Lok, T. Woelders, M. J. van Koningsveld, K. Oberman, S. G. Fuhler, D. G. M. Beersma, R. A. Hut

Publikováno v: Journal of Biological Rhythms, 37(4), 417-428. SAGE Publications Inc.

Human thermoregulation is strictly regulated by the preoptic area of the hypothalamus, which is directly influenced by the suprachiasmatic nucleus (SCN). The main input pathway of the SCN is light. Here, thermoregulatory effects of light were assesse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f798adc73ff5666aad89e68e66eb95b9
https://research.rug.nl/en/publications/ed08adb8-ddc7-4077-85e2-b0a79484bf20

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Bright Light Increases Alertness and Not Cortisol in Healthy Men: A Forced Desynchrony Study Under Dim and Bright Light (I)

Autor: R. Lok, T. Woelders, M. J. van Koningsveld, K. Oberman, S. G. Fuhler, D. G. M. Beersma, R. A. Hut

Publikováno v: Journal of Biological Rhythms, 37(4). SAGE Publications Inc.

Light-induced improvements in alertness are more prominent during nighttime than during the day, suggesting that alerting effects of light may depend on internal clock time or wake duration. Relative contributions of both factors can be quantified us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e913ad3f1ac91447d6d54f2953891dd
https://doi.org/10.1177/07487304221096945

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Akademický článek

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P555 Ustekinumab tissue and serum levels in patients with Crohn’s disease are closely correlated though not consistently associated with objective response after induction

Autor: E Proietti, A Bayoumy, R Pauwels, J van der Woude, M Doukas, L Oudijk, M Peppelenbosch, U Grohmann, R Crombag, A de Vries, G Fuhler

Publikováno v: Journal of Crohn's and Colitis. 16:i500-i501

Background Ustekinumab (UST), which targets p40 of IL23/IL12, is an effective treatment for Crohn’s disease (CD). Therapeutic drug monitoring (TDM) may optimize UST posology. The aim of this study was to investigate UST and IL23 serum and tissue co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cef103351d3cd880f6421083fed6cf1c
https://doi.org/10.1093/ecco-jcc/jjab232.681

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Light effects on circadian and homeostatic regulation: alertness increases independent of time awake

Autor: Minke J. van Koningsveld, Klaske Oberman, Roelof A. Hut, Domien G. M. Beersma, Sebastiaan G. Fuhler, Renske Lok, Tom Woelders

Light induced improvements in alertness are more prominent during night-time than during the day, indicating circadian regulation or wake duration related dependence. Relative contributions of both factors can be quantified using a forced desynchrony

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d6ffe25236604775e1bbba8d48f691

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