Zobrazeno 1 - 10
of 49
pro vyhledávání: '"G F Orr"'
Autor:
S. S. Joyner, David P. Baccanari, G. F. Orr, James L. Kelley, David Lee Musso, Stephen T. Davis
Publikováno v:
Journal of Medicinal Chemistry. 40:1179-1185
Structure-activity relationship studies on a series of 1-((2-hydroxyethoxy)methyl)-5-(3-(substituted-phenoxy)benzyl)uracils as inhibitors of murine liver uridine phosphorylase have led to compounds with IC50s as low as 1.4 nM. The two most potent com
Autor:
David Lee Musso, James L. Kelley, Boswell Grady Evan, G. F. Orr, S. S. Joyner, David P. Baccanari, Stephen T. Davis
Publikováno v:
Journal of Medicinal Chemistry. 38:3850-3856
A series of 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils were synthesized and tested for inhibition of murine liver uridine phosphorylase (UrdPase). Inhibitors of UrdPase are reported to enhance the chemotherapeutic utility of 5-fluoro-2'-deoxyuridine
Autor:
Stephen T. Davis, David Lee Musso, David P. Baccanari, G. F. Orr, Boswell Grady Evan, S. S. Joyner, James L. Kelley
Publikováno v:
ChemInform. 27
A series of 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils were synthesized and tested for inhibition of murine liver uridine phosphorylase (UrdPase). Inhibitors of UrdPase are reported to enhance the chemotherapeutic utility of 5-fluoro-2'-deoxyuridine
Autor:
David Lee Musso, G. F. Orr
Publikováno v:
ChemInform. 27
Publikováno v:
Antiviral Chemistry and Chemotherapy. 3:157-164
Eighteen amino acid esters of the antiherpetic drug, acyclovir, were synthesized as potential prodrugs for oral administration. The esters were examined for in vitro antiviral activity against herpes simplex virus Type 1 (HSV-1). They were found to h
Autor:
A R Moorman, Joel Van Tuttle, Lilia M. Beauchamp, Thomas A. Krenitsky, G. F. Orr, Wayne H. Miller
Publikováno v:
Journal of Biological Chemistry. 265:3066-3069
The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major
Autor:
R J Ott, Kurt Weaver, David K. Stammers, G F Orr, Joseph H. Chan, Andrew L. Hopkins, Douglas B. Sherman, Steven A. Short, R G Ferris, S M Sparks, M St Clair, David I. Stuart, C W Andrews Iii, Robert N. Hunter, B E Reitter, J S Hong, K L Creech, G B Roberts, Cowan, L R Boone, Jingshan Ren, Richard J. Hazen
Publikováno v:
Journal of medicinal chemistry. 44(12)
A series of 2-amino-5-arylthiobenzonitriles (1) was found to be active against HIV-1. Structural modifications led to the sulfoxides (2) and sulfones (3). The sulfoxides generally showed antiviral activity against HIV-1 similar to that of 1. The sulf
Publikováno v:
The Journal of biological chemistry. 265(6)
The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major
Autor:
Amelia C. Stolk, G. F. Orr
Publikováno v:
Mycologia. 66:676-680
SUMMARY Sagenoma, a new genus of the Eurotiaceae, is proposed. The genus, based on the single species S. viride, is characterized by ascomata surrounded by loose networks of dark peridial hyphae, asci in chains, 1celled ascospores, and a conidial sta
Autor:
Harold H. Kuehn, G. F. Orr
Publikováno v:
Mycologia. 56:482-487
(1964). A New Genus of the Gymnoascaceae with Dark Ascocarps. Mycologia: Vol. 56, No. 4, pp. 482-487.