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PHARMACOKINETICS OF AN ORAL SOLUTION OF THE MICROEMULSION FORMULATION OF CYCLOSPORINE IN MAINTENANCE PEDIATRIC LIVER TRANSPLANT RECIPIENTS1

Autor: Smith Ht, Sue V. McDiarmid, G F Cooney, R. Wong, Sommerauer J, Stephen P. Dunn, Choc Mg, Chang Ct, Lindsay C

Publikováno v: Transplantation. 63:1762-1767

Background. A comparison of the oral bioavailability of cyclosporine from the original formulation (CsA) and from the new formulation, cyclosporine for microemulsion (CsA-ME), was made in pediatric maintenance liver transplant patients within two age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::261272c2015b2991e81ef8e6c6fd256d
https://doi.org/10.1097/00007890-199706270-00010

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Cyclosporin Pharmacokinetics in Paediatric Transplant Recipients

Autor: G F Cooney, Karen Habucky, Kalle Hoppu

Publikováno v: Clinical Pharmacokinetics. 32:481-495

Cyclosporin is an essential component of the antirejection drug protocol used in the long term management of paediatric organ transplant recipients. This article looks at the pharmacokinetics of cyclosporin in paediatric kidney, heart, liver and bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5cdfaa9025559bea7d597a77257982
https://doi.org/10.2165/00003088-199732060-00004

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Sequestration of vecuronium bromide during extremity surgery involving use of a pneumatic tourniquet

Autor: Neil W. Brister, Christer Carlsson, M. L. Sharma, N. Johanson, Rodger E. Barnette, G. F. Cooney, Lars Eriksson

Publikováno v: Acta Anaesthesiologica Scandinavica. 41:49-54

BACKGROUND We hypothesized that sequestration of a neuromuscular blocking agent could occur during surgery involving use of an extremity tourniquet and cause changes in neuromuscular function after tourniquet release. METHODS Sixteen patients schedul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b82393d5c14a5b551935fc571935600
https://doi.org/10.1111/j.1399-6576.1997.tb04612.x

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Pharmacokinetics of Cyclosporine after Renal Transplant in Children

Autor: Manuel Mochon, H J Baluarte, G F Cooney, G C Caputo, M S Polinsky, Bruce A. Kaiser, Stephen P. Dunn, B Lum, Barbara M. Goldsmith

Publikováno v: The Journal of Clinical Pharmacology. 36:580-586

The pharmacokinetics of cyclosporine and the relationship between blood levels and average drug concentration were prospectively evaluated in 18 children 1 month after renal transplantation. All children had normal renal function and no hepatic or ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c015d48f335615bc8067c578d20f6e
https://doi.org/10.1002/j.1552-4604.1996.tb04221.x

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ABSORPTION CHARACTERISTICS OF A MICROEMULSION FORMULATION OF CYCLOSPORINE IN DE NOVO PEDIATRIC LIVER TRANSPLANT RECIPIENTS1,2

Autor: John A. Meligeni, Stephen P. Dunn, G F Cooney, Anatoly Kulinsky, Andrea Pierson, Cheryl A. Elder, Kathleen Falkenstein

Publikováno v: Transplantation. 60:1438-1442

In pediatric liver transplant recipients, oral cyclosporine (CsA) therapy may be complicated by impaired or delayed absorption during the initial weeks posttransplant. Neoral (NL) is a microemulsion preconcentrate formulation of CsA expected to incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b752cd03ca54a814e6a67020a850e283
https://doi.org/10.1097/00007890-199560120-00012

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Reduced cyclosporine absorption preceded acute allograft rejection in a child with a liver transplant

Autor: J A Meligeni, K Falkenstein, A. V. Kulinsky, A Pierson, Stephen P. Dunn, G F Cooney

Publikováno v: Liver Transplantation and Surgery. 3:538-540

This case report correlates impaired cyclosporine absorption from the traditional oral formulation in a 9-year-old liver transplant recipient with subsequent acute allograft rejection. Although impaired absorption in this patient was documented by cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645d793fe143754a9389f45b38c0d321
https://doi.org/10.1002/lt.500030510

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Improved cyclosporine bioavailability in black pediatric liver transplant recipients after administration of the microemulsion formulation

Autor: Stephen P. Dunn, Christine A. Lindsay, G F Cooney, M. Gerry Choc, Cheng-Tao Chang, R. Wong, Sue V. McDiarmid, John F. Sommerauer, Harold T. Smith

Publikováno v: Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 5(2)

Black transplant recipients are associated with low cyclosporine bioavailability, which may contribute to the poorer clinical outcomes observed with these patients. In this analysis, we compared cyclosporine exposure in black (n = 9) and nonblack (n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270d0f717c685274169a2cc48709825b
https://pubmed.ncbi.nlm.nih.gov/10071350

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Comparison and validation of limited sampling equations for cyclosporine area-under-the-curve monitoring calculations in pediatric renal transplant recipients

Autor: G F Cooney, Charlebois Je, Manuel Mochon, B Lum, Kaiser Ba

Publikováno v: Therapeutic drug monitoring. 19(3)

Therapeutic monitoring of cyclosporine (CsA) by using area-under-the-concentration-time-curve (AUC) values in renal transplant recipients has been previously demonstrated to predict posttransplant clinical outcome. Two previous studies also reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb770d8411ca33530c0e2f7d9d0f89f
https://pubmed.ncbi.nlm.nih.gov/9200762

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