Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD Study

Autor: Margery H. Mark, P. Vieregge, Ravi Prakash, David J. Burn, Irene Litvan, J. E. Tobin, Patrick F. Chinnery, Mark F. Lew, Christine Klein, Anita L. DeStefano, Marie Saint-Hilaire, Richard H. Myers, Garth A. Nicholson, JT Slevin, Peter P. Pramstaller, Mark Guttman, Mei Sun, Stefano Goldwurm, Lawrence I. Golbe, Abbas Parsian, Holly A. Shill, S. Williamson, Brad A. Racette, G. F. Wooten, CJ Berg, Kenneth B. Baker, James F. Gusella, Oksana Suchowersky, Carlos Singer, Jeanne C. Latourelle, M. L. Giroux, Marcy E. MacDonald, Gianni Pezzoli, Ray L. Watts, John H. Growdon, Franca Cambi, Jemma B. Wilk, Joel S. Perlmutter

Publikováno v: Neurology. 67:2206-2210

Background: Polymorphisms in the glutathione S-transferase pi gene ( GSTP1 ), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with exposure to pesticides. Using the Gene PD Study sample of familial PD cases,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4284eb5cc990061e837eac092db7e37c
https://doi.org/10.1212/01.wnl.0000249149.22407.d1

A haplotype at the PARK3 locus influences onset age for Parkinson's disease: The GenePD study

Autor: Mark Stacy, Robert G. Feldman, Samer Karamohamed, S. J. Fink, Christine Klein, Gang Xu, Jemma B. Wilk, Alan Herbert, Carlos Singer, N. Labelle, Alice Lazzarini, Joel S. Perlmutter, Lillian J. Currie, Kenneth B. Baker, Marie Saint-Hilaire, Richard H. Myers, Mark Guttman, James F. Gusella, Lawrence I. Golbe, Peter Vieregge, Erwin B. Montgomery, Anita L. DeStefano, Mark F. Lew, Oksana Suchowersky, A. Parsian, Margery H. Mark, K. M. Sullivan, Brad A. Racette, G. F. Wooten, Peter P. Pramstaller, Cheryl H. Waters, Christina M. Shoemaker, Ray L. Watts, John H. Growdon

Publikováno v: Neurology. 61:1557-1561

Objective: To identify a haplotype influencing onset age for Parkinson’s disease (PD) in the PARK3 region on chromosome 2p13. Methods: Single nucleotide polymorphisms (SNP) spanning 2.2 Mb and located in or near potential candidate genes were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c596cace05c4dd64a3237b189e7cf020
https://doi.org/10.1212/01.wnl.0000095966.99430.f4

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

Autor: Peter P. Pramstaller, S. Tobin, Kenneth B. Baker, Scott J. Sherman, Mark Guttman, Ravi Prakash, Christine Klein, David J. Burn, J. Williamson, Oksana Suchowersky, Ray L. Watts, Stefano Goldwurm, Anita L. DeStefano, Patrick F. Chinnery, P. Vieregge, Brad A. Racette, Carlos Singer, Garth A. Nicholson, Mark F. Lew, Marie Saint-Hilaire, J. F. Gusella, Richard H. Myers, M. L. Giroux, G. F. Wooten, Jeanne C. Latourelle, N. Labell, Holly A. Shill, Lawrence I. Golbe, Jemma B. Wilk, Joel S. Perlmutter, B. N.J. Growdon, Samer Karamohamed, Gianni Pezzoli, Margery H. Mark, Irene Litvan, Abbas Parsian

Publikováno v: Neurology. 65:1823-1825

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2380b7a77f4ff3592c8380576c378a1f
https://doi.org/10.1212/01.wnl.0000187075.81589.fd

Autosomal dominant subcortical gliosis presenting as frontotemporal dementia

Autor: H. R. Brashear, G. F. Wooten, Carol A. Manning, M. Fowler, P. Damgaard, M.B.S. Lopes, J. W. Mandell, Bradley Miller, Russell H. Swerdlow

Publikováno v: Neurology. 72(3)

Objective: To describe a multigenerational kindred with a frontotemporal dementia clinical syndrome (FTDS), extensive subcortical gliosis pathology, and autosomal dominant genetics. Methods: Clinical, imaging, and pathologic evaluations of multiple f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1131832828a01c6e2f907ed807309520
https://pubmed.ncbi.nlm.nih.gov/19153373

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study

Autor: Stuart Isaacson, Jemma B. Wilk, Mark Guttman, Joel S. Perlmutter, Christine Klein, Richard Roxburgh, Tiffany Massood, Kenneth B. Baker, Oksana Suchowersky, Brad A. Racette, S. Williamson, Ray L. Watts, Holly A. Shill, Jeanne C. Latourelle, Marie Saint-Hilaire, Patrick F. Chinnery, Richard H. Myers, Mark F. Lew, Michael W. Nagle, Carlos Singer, M. Nance, Jason M. Laramie, Barry Snow, J. F. Gusella, J. E. Tobin, John T. Slevin, Karen Østergaard, Franca Cambi, Peter P. Pramstaller, Stefano Goldwurm, David J. Burn, Jomana T. Al-Hinti, John H. Growdon, Audrey E. Hendricks, Anita L. DeStefano, Alastair Corbett, Garth A. Nicholson, Scott J. Sherman, Lawrence I. Golbe, Anette Torvin Møller, Margery H. Mark, Irene Litvan, G. F. Wooten, Edward Drasby, Gianni Pezzoli

Publikováno v: Tobin, J E, Latourelle, J C, Lew, M F, Klein, C, Suchowersky, O, Shill, H A, Golbe, L I, Mark, M, Growdon, J H, Wooten, G F, Racette, B A, Perlmutter, J S, Watts, R, Guttman, M, Baker, K B, Goldwurm, S, Pezzoli, G, Singer, C, Saint-Hilaire, M H, Hendricks, A E, Williamson, S, Nagle, M W, Wilk, J B, Massood, T, Laramie, J M, DeStefano, A L, Litvan, I, Nicholson, G, Corbett, A, Isaacson, S, Burn, D J, Chinnery, P F, Pramstaller, P P, Sherman, S, Al-hinti, J, Drasby, E, Nance, M, Møller, A T, Østergaard, K, Roxburgh, R, Snow, B, Slevin, J T, Cambi, F, Gusella, J F & Myers, R H 2008, ' Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study ', Neurology, vol. 71, no. 1, pp. 28-34 . https://doi.org/10.1212/01.wnl.0000304051.01650.23

Background: Microtubule-associated protein tau ( MAPT ) has been associated with several neurodegenerative disorders including forms of parkinsonism and Parkinson disease (PD). We evaluated the association of the MAPT region with PD in a large cohort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d281389c08229152d5731adf96cc0f95
https://europepmc.org/articles/PMC2654275/