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Akademický článek

Sequence Analysis of the Mouse RAG Locus lntergenic Region

Autor: F. E. Bertrand III, S. L. Olsona, D. A. Martin, G. E. Wu

Publikováno v: Clinical and Developmental Immunology, Vol 5, Iss 3, Pp 215-222 (1998)

Externí odkaz: https://doaj.org/article/f7a915cacbf449baae2d11f7399ff4e3

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Akademický článek

Sequence of the RAG1 and RAG2 Intergenic Region inZebrafish (Danio rerio)

Autor: F. E. Bertrand III, S. L. Olson, C. E. Willett, G. E. Wu

Publikováno v: Clinical and Developmental Immunology, Vol 5, Iss 3, Pp 211-214 (1998)

Externí odkaz: https://doaj.org/article/90bac859ffaa4d69bd1eba9400ea9fbd

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Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation

Autor: L A Bentolila, G E Wu, F Nourrit, M Fanton d'Andon, F Rougeon, N Doyen

Publikováno v: The Journal of Immunology. 158:715-723

N region diversity in Ag receptors is a developmentally regulated process in B and T cells that correlates with the differential expression of terminal deoxynucleotidyl transferase (TdT). Absent in fetal and newborn mice, TdT expression is restricted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84f58b7b910b1ed827047d8d57be6d87
https://doi.org/10.4049/jimmunol.158.2.715

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Frequency of VH81x usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression

Autor: A J Marshall, G E Wu, G J Paige

Publikováno v: The Journal of Immunology. 156:2077-2084

B cell development is marked by changes in the pattern of VH segment utilization. B cell precursors characteristically utilize a restricted set of VH segments, while mature B cell populations use a wide range of VH segments. VH81x is an example of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abe8c0efe4597e879aa0e6561cdbfca6
https://doi.org/10.4049/jimmunol.156.6.2077

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Kappa light chain rearrangement in mouse fetal liver

Autor: D A Ramsden, C J Paige, G E Wu

Publikováno v: The Journal of Immunology. 153:1150-1160

Ig variable domains are generated by the recombination of V, D, and J segments (V(D)J rearrangement). V(D)J rearrangement is capable of generating a vast repertoire of different variable domains. In this report, we quantify and characterize the reper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53635120311228dde88b3ad8605fc25b
https://doi.org/10.4049/jimmunol.153.3.1150

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Ig gene rearrangements on individual alleles of Abelson murine leukemia cell lines from (C57BL/6 x BALB/c) F1 fetal livers

Autor: M J Atkinson, D A Michnick, C J Paige, G E Wu

Publikováno v: The Journal of Immunology. 146:2805-2812

We have previously shown that selection of Ig H chain V region genes used by colonies obtained from splenic B cells and fetal liver pre-B cells was dependent on strain-specific factors. Moreover, by examining the V gene usage in strains congenic at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e90835491221a9d305b84d3a3a3c7cd1
https://doi.org/10.4049/jimmunol.146.8.2805

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Association of Ig L chain-like protein lambda 5 with a 16-kilodalton protein in mouse pre-B cell lines is not dependent on the presence of Ig H chain protein

Autor: V Misener, J Jongstra-Bilen, A J Young, M J Atkinson, G E Wu, J Jongstra

Publikováno v: The Journal of Immunology. 145:905-909

Using a polyclonal rabbit antiserum against recombinant mouse lambda 5 protein, we determined that the pre-B cell specific mouse lambda 5 gene encodes a 22-kDa protein. The lambda 5 protein, which is related to conventional Ig lambda L chain proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::139211de752a9f372d2f5c7913dd74c7
https://doi.org/10.4049/jimmunol.145.3.905

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Valpha gene replacement in a TCRalpha knock-in mouse

Autor: R, Golub, C Y, Huang, O, Kanagawa, G E, Wu

Publikováno v: European journal of immunology. 31(10)

Using a TCRalpha chain knock-in mouse, we demonstrate that V-gene replacement can operate in the T cell receptor alpha locus. Functional TCRalpha chain transcripts generated by Valpha-gene replacement at the site of the Valpha-embedded heptamer were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba0ae0f2116f11c955a77c2db30c0150
https://pubmed.ncbi.nlm.nih.gov/11592067

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Specific antibody production by V(H)-gene replacement

Autor: M K, Madan, R, Golub, M, Wabl, G E, Wu

Publikováno v: European journal of immunology. 30(8)

V(H)-gene replacement is a recombination event in which a pre-existing immunoglobulin heavy chain gene can be altered by the replacement of the rearranged V(H) gene segment with another V(H) gene segment. Although this event has been demonstrated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee8675c9996161ddd986bdb99fe27f52
https://pubmed.ncbi.nlm.nih.gov/10940932

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