Zobrazeno 1 - 10
of 82
pro vyhledávání: '"G E Mortimore"'
Autor:
Motoni Kadowaki, G E Mortimore
Publikováno v:
Comprehensive Physiology
The sections in this article are: 1 Turnover of Cellular Protein and RNA 1.1 Determination of General Protein Turnover 1.2 Classes of General Protein Turnover 1.3 Cytoplasmic RNA Turnover 2 Autophagy 2.1 Macroautophagy 2.2 Microautophagy 2.3 A Unifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdec4f8a4d181f91f513c7ba9fe07249
https://doi.org/10.1002/cphy.cp070217
https://doi.org/10.1002/cphy.cp070217
Publikováno v:
Biochemical and Biophysical Research Communications. 203:200-208
Leu8-MAP (Multiple Antigen Peptide) is an effective inhibitor of macroautophagy and proteolysis in the isolated rat hepatocyte, having an apparent Km (0.1 mM) equaling leucine. Since it is not transported into the cytosolic compartment, it very likel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a3c256877b4e6b314edf6135f28d25
https://doi.org/10.1006/bbrc.1994.2168
https://doi.org/10.1006/bbrc.1994.2168
Publikováno v:
Journal of Biological Chemistry. 267:22060-22065
Intracellular protein degradation in the rat hepatocyte is regulated by 7 amino acids of which Leu, Gln, and Tyr play major roles. Although Phe is known to inhibit proteolysis as effectively as Tyr at high concentrations, it has not been regarded as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36db401dcdebba04a4d7c4627fe82c83
https://doi.org/10.1016/s0021-9258(18)41635-3
https://doi.org/10.1016/s0021-9258(18)41635-3
Publikováno v:
Journal of Biological Chemistry. 266:8790-8796
Past evidence has suggested that the lysosomal pathway is an important site of cytoplasmic RNA degradation in the hepatic parenchymal cell (Lardeux, B. R., Heydrick, S. J., and Mortimore, G. E. (1987) J. Biol. Chem. 262, 14507-14519). We now provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80967a076e6510c10d3aac940f615e1
https://doi.org/10.1016/s0021-9258(18)31516-3
https://doi.org/10.1016/s0021-9258(18)31516-3
Autor:
Charles M. Schworer, G E Mortimore
Publikováno v:
Ciba Foundation Symposium 75-Protein Degradation in Health and Disease
Amino acids appear to be prime regulators of autophagy and proteolysis in liver. They both attain a maximum rapidly when livers from fed rats are perfused in the single-pass mode without amino acids and are suppressed to basal levels by amino acid ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35252e171c06fd4c7a03fb4d151924aa
https://doi.org/10.1002/9780470720585.ch17
https://doi.org/10.1002/9780470720585.ch17
Publikováno v:
Intracellular Protein Catabolism ISBN: 9781461380030
Autophagic vacuoles in hepatocytes are formed from membranes of rough and smooth endoplasmic reticulum (ER) by processes that are under immediate physiologic control by amino acids, insulin, and glucagon (reviewed in 1). Little, though, is known of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::068d2ef366668f1770c19042a94e8723
https://doi.org/10.1007/978-1-4613-0335-0_13
https://doi.org/10.1007/978-1-4613-0335-0_13
Publikováno v:
Sub-cellular biochemistry. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e3830df011fce702de0dd2e2798e611
https://pubmed.ncbi.nlm.nih.gov/8993159
https://pubmed.ncbi.nlm.nih.gov/8993159
Publikováno v:
Europe PubMed Central
The role of GTP-binding proteins in autophagic vacuole formation was investigated in isolated rat hepatocytes permeabilized by alpha-toxin from Staphylococcus aureus, an agent which creates stable plasma membrane channels allowing exchange of small (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa99a789a1ad66f52e315711576d0d2
https://pubmed.ncbi.nlm.nih.gov/8106415
https://pubmed.ncbi.nlm.nih.gov/8106415
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Autophagically mediated proteolysis in the perfused rat liver is under complex multiphasic control by a small group of amino acids dominated by leucine. Because there have been no prior reports of such regulation in the isolated hepatocyte, our goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8297214de957cc3ffdac57046e84d464
http://hdl.handle.net/11577/2488344
http://hdl.handle.net/11577/2488344
Publikováno v:
The Journal of biological chemistry. 267(31)
Intracellular protein degradation in the rat hepatocyte is regulated by 7 amino acids of which Leu, Gln, and Tyr play major roles. Although Phe is known to inhibit proteolysis as effectively as Tyr at high concentrations, it has not been regarded as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d03f0fdfdfdfe7775027ad4b611c9a93
https://pubmed.ncbi.nlm.nih.gov/1429557
https://pubmed.ncbi.nlm.nih.gov/1429557