Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G E, Tomlinson"'
Publikováno v:
Cancer research. 61(21)
Gamma-radiation results in cell cycle arrest and apoptosis in a wide variety of cells. Cell cycle arrest provides time for the cell to repair damaged DNA before entering the next phase of the cycle. If the damage is severe and cannot be repaired, the
Publikováno v:
The Journal of family practice. 49(12)
Primary care physicians will be providing longitudinal health care for long-term survivors of childhood acute lymphoblastic leukemia (ALL) with increasing frequency. Late effects (sequelae) secondary to treatment with radiation or chemotherapeutic ag
Autor:
I I, Wistuba, G E, Tomlinson, C, Behrens, A, Virmani, J, Geradts, J L, Blum, J D, Minna, A F, Gazdar
Publikováno v:
Genes, chromosomescancer. 28(4)
Monozygotic twins, each of whom has breast cancer, offer a natural study population for gene-environmental interactions as causation of cancer, because they are genetically identical. If heritable factors play a large role in the origin of a neoplasm
Publikováno v:
Cancer. 88(7)
The objective of the current study was to describe a multidisciplinary transition program for following young adult survivors of childhood cancer in an adult-based ambulatory medical setting and to report the late effects with grades of toxicity diag
Publikováno v:
Cancer research. 59(15)
Mutations in BRCA1 and BRCA2 account for the majority of familial breast cancers. Cells with mutated BRCA1 or BRCA2 are hypersensitive to ionizing radiation (IR) and exhibit defective DNA repair. Both BRCA1 and BRCA2 have been reported to bind Rad51,
Autor:
G E, Tomlinson, T T, Chen, V A, Stastny, A K, Virmani, M A, Spillman, V, Tonk, J L, Blum, N R, Schneider, I I, Wistuba, J W, Shay, J D, Minna, A F, Gazdar
Publikováno v:
Cancer research. 58(15)
A tumor cell line, HCC1937, was established from a primary breast carcinoma from a 24-year-old patient with a germ-line BRCA1 mutation. A corresponding B-lymphoblastoid cell line was established from the patient's peripheral blood lymphocytes. BRCA1
Publikováno v:
Cancer research. 58(8)
3p deletion, a common chromosome defect in lung cancer, occurs more frequently in the lung tumor tissues of smoking patients than it does in those of nonsmoking patients. This pilot study evaluated whether 3p aberrations induced by benzo[a]pyrene dio
Autor:
M, Ahmadian, I I, Wistuba, K M, Fong, C, Behrens, D R, Kodagoda, M H, Saboorian, J, Shay, G E, Tomlinson, J, Blum, J D, Minna, A F, Gazdar
Publikováno v:
Cancer research. 57(17)
The FHIT gene, which spans the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in breast and other cancers. We investigated FHIT and FRA3B for loss of heterozygosity (LOH); homozygous deletions; abnormal transcripts; and
Publikováno v:
Genes, chromosomescancer. 19(4)
We report four cases of hepatoblastoma with a derivative chromosome 4 from an unbalanced translocation between the long arms of chromosomes 1 and 4, an aberration reported only rarely in isolated cases of other types of neoplasms. The abnormality in
Autor:
G E, Tomlinson
Publikováno v:
Cancer treatment and research. 92