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Large-scale preparation and biochemical characterization of a new high purity factor IX concentrate prepared by metal chelate affinity chromatography

Autor: M A Pinnell, L. Harris, D R Evans, J D Williams, G E Sims, J W McPhee, P A Feldman, G I Crombie, P I Bradbury

Publikováno v: Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 5(6)

Metal chelate affinity chromatography on copper-charged Chelating Sepharose has been used to purify a factor IX concentrate from 4,000- to 5,000-kg pools of human plasma, with an overall yield of 194 IU/kg. Unwanted proteins and solvent-detergent rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9fc19fb256c021a5597e6524708945
https://pubmed.ncbi.nlm.nih.gov/7893930

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A Pasteurised Concentrate of Human Plasma Factor XIII for Therapeutic Use

Autor: L. Winkelman, G E Sims, M.E. Haddon, J. K. Smith, D R Evans

Publikováno v: Thrombosis and Haemostasis. 55:402-405

SummaryA therapeutic concentrate of factor XIII containing both A and B sub-units has been prepared from 300 kg pools of human plasma. The process starts from a cold-ethanol fraction from cryoprecipitate supernatant and therefore does not interfere w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c857c169a5e207a331980724ac14693d
https://doi.org/10.1055/s-0038-1661573

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Ultrasonic Velocity of Sound and Void Fraction in a Bubbly Mixture

Autor: R. E. Chant, G. E. Sims, D. C. Card

Publikováno v: Journal of Basic Engineering. 93:619-623

The velocity of sound at a frequency much greater than resonance in a bubbly air-water mixture has been measured for varying void fractions in a “pool” system. Only measurements of acoustic velocity well below resonance for varying void fraction,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b997d665668749f6129e8b3ad087c2e6
https://doi.org/10.1115/1.3425317

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Equipment for linking the AutoAnalyzer on-line to a computer

Autor: M. I. Harrison, L. G. Whitby, G. E. Sims, D. Simpson

Publikováno v: Journal of Clinical Pathology. 24:170-176

An Elliott 903 computer with 8K central core store and magnetic tape backing store has been operated for approximately 20 months in a clinical chemistry laboratory. Details of the equipment designed for linking AutoAnalyzers on-line to the computer a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24738d4d033a9531cebcfbf0f71b2ed
https://doi.org/10.1136/jcp.24.2.170

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A pasteurized antithrombin III concentrate for clinical use

Autor: D R Evans, L. Winkelman, G E Sims, J. K. Smith, M.E. Haddon

Publikováno v: Vox sanguinis. 48(6)

A method for large-scale production of a pasteurized antithrombin III (AT III) concentrate for therapeutic use has been adapted from published methods. It includes the following steps: (1) batchwise adsorption onto heparin-Sepharose from plasma deple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1768c72972a947f81c3ed4e6386fb090
https://pubmed.ncbi.nlm.nih.gov/4013136

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A pasteurised concentrate of human plasma factor XIII for therapeutic use

Autor: L, Winkelman, G E, Sims, M E, Haddon, D R, Evans, J K, Smith

Publikováno v: Thrombosis and haemostasis. 55(3)

A therapeutic concentrate of factor XIII containing both A and B sub-units has been prepared from 300 kg pools of human plasma. The process starts from a cold-ethanol fraction from cryoprecipitate supernatant and therefore does not interfere with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06b26f39d702efc48744727e3209efeb
https://pubmed.ncbi.nlm.nih.gov/3750269

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