Zobrazeno 1 - 10
of 31
pro vyhledávání: '"G E, Isom"'
Publikováno v:
Toxicology and Applied Pharmacology. 134:1-17
We are an aging society and current demographic trends point to a likely increase in age-related neurodegenerative diseases. The aged population may have a number of unique risk factors that result in a predisposition to neuronal damage from environm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c6c48e6a7eac40e54bf53c774674a4
https://doi.org/10.1006/taap.1995.1163
https://doi.org/10.1006/taap.1995.1163
Publikováno v:
Toxicological Sciences. 20:133-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b824e3fdf6aa3f7cb5345e3814f4ad
https://doi.org/10.1093/toxsci/20.2.133
https://doi.org/10.1093/toxsci/20.2.133
Publikováno v:
Neurotoxicology. 21(4)
Pyridostigmine is a reversible cholinesterase (ChE) inhibitor that is associated with neurologic dysfunction involving both central and peripheral nervous systems. To determine the neurotoxic potential of pyridostigmine, rats were sacrificed at inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76ffc8e998c006b06c326c7a5b86f693
https://pubmed.ncbi.nlm.nih.gov/11022862
https://pubmed.ncbi.nlm.nih.gov/11022862
Publikováno v:
Journal of neuroscience research. 61(5)
In a study of the mechanism by which cyanide is produced in neural tissue, it was hypothesized that nerve cells generate cyanide in a manner similar to that in leukocytes. As in white blood cells, glycine addition enhanced cyanide production in rat p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acbec491f42d95f29483e893870dec85
https://pubmed.ncbi.nlm.nih.gov/10956427
https://pubmed.ncbi.nlm.nih.gov/10956427
Publikováno v:
Journal of biochemical and molecular toxicology. 13(5)
Activation of NMDA receptors plays an important role in cyanide neurotoxicity. Cyanide indirectly activates the receptor by inducing neuronal release of glutamate and also enhances receptor-mediated responses by a direct interaction with the receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b727c2e81d8eadd0d62e93a1bd9d9abb
https://pubmed.ncbi.nlm.nih.gov/10402559
https://pubmed.ncbi.nlm.nih.gov/10402559
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(1)
In cerebellar granule cells, potassium cyanide (KCN) activates the NMDA receptor resulting in generation of nitric oxide and reactive oxygen species (ROS). To study the mechanism by which KCN stimulates ROS generation, the action of cyanide on the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2467b4f0016315145b49c003648ec82
https://pubmed.ncbi.nlm.nih.gov/9536016
https://pubmed.ncbi.nlm.nih.gov/9536016
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(3)
The effect of cyanide on the N-methyl-D-aspartate (NMDA)-stimulated increase in cytosolic free calcium ([Ca++]i) was studied by microfluorescence in fura-2-loaded cerebellar granule cells. The response to NMDA was enhanced by NaCN over a concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f927996e9ff6e2aeee94e697d63ded5c
https://pubmed.ncbi.nlm.nih.gov/9067322
https://pubmed.ncbi.nlm.nih.gov/9067322
Publikováno v:
Journal of biochemical toxicology. 11(5)
Cyanide-induced neurotoxicity is associated with altered cellular Ca2+ homeostasis resulting in sustained elevation of cytosolic Ca2+. In order to characterize the effect of cyanide on intracellular signaling mechanisms, the interaction of KCN with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6900fc88af44f22b4296ebb80e43fd1c
https://pubmed.ncbi.nlm.nih.gov/9110247
https://pubmed.ncbi.nlm.nih.gov/9110247
Publikováno v:
Neurotoxicology. 16(1)
Excitatory amino acid (EAA)-like and excitotoxic properties of the secondary metabolite of cyanide, 2-iminothiazolidine-4-carboxylic acid, (2-ICA) were evaluated because of its possible role in cyanide-induced neurotoxicity. Intracerebroventricular (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7f07cad6e26628114a77bcc6b4eea75
https://pubmed.ncbi.nlm.nih.gov/7603631
https://pubmed.ncbi.nlm.nih.gov/7603631
Publikováno v:
Neurotoxicology. 15(4)
Incubation of rat pheochromocytoma (PC12) cells with cyanide (1-10 mM) for 30 min produced a compound which eluted between dopamine (DA) and 3,4-dihydroxyphenylacetic acid in HPLC-EC analysis. Generation of the compound was rapid, concentration-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2025c2869d49dcd126028a9ef1720c7
https://pubmed.ncbi.nlm.nih.gov/7715859
https://pubmed.ncbi.nlm.nih.gov/7715859