Zobrazeno 1 - 10
of 21
pro vyhledávání: '"G E, Gallick"'
Publikováno v:
Angiogenesis. 4(2)
Small tumor vessels are composed of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). These cells have been shown to communicate with each other via cytokine signaling during neovascularization. We previously demonstrated that interle
Autor:
G E, Gallick
Publikováno v:
Cancer journal (Sudbury, Mass.). 6(4)
Publikováno v:
Cancer research. 59(19)
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor important for colon cancer neovascularization. In previous studies, serum starvation led to induction of VEGF in human colon carcinoma cells. We investigated the possible partici
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(8)
The Src protein tyrosine kinase is overexpressed and activated in a number of human cancers, including some human ovarian cancers. To determine whether Src activity plays a role in ovarian tumor growth, stable derivatives of the SKOv-3 human ovarian
Publikováno v:
The Journal of biological chemistry. 274(26)
Since c-src overexpression increases colonic cell invasiveness and because both Src activity and urokinase receptor protein are elevated in invasive colon cancers, the present study was undertaken: 1) to determine if a constitutively active Src regul
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(3)
In greater than 80% of colon tumors and established cell lines, the specific activities of the protein tyrosine kinases pp60(c-src) and pp62(c-yes) are increased with respect to normal colonic epithelial cells. However, no mutations in either gene ha
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(8)
pp60(c-src) and pp62(c-yes) are protein tyrosine kinases whose specific activities are increased in primary colorectal carcinomas. Activity of pp60(c-src) is further increased in colorectal liver metastases. This study was undertaken to compare pp60(
Autor:
S, Untawale, M A, Zorbas, C P, Hodgson, R J, Coffey, G E, Gallick, S M, North, D M, Wildrick, M, Olive, M, Blick, L C, Yeoman
Publikováno v:
Cancer research. 53(7)
The DiFi colorectal carcinoma cell line, derived from a patient with familial adenomatous polyposis, was examined for gene expression and production of the autocrine growth factor transforming growth factor alpha (TGF-alpha) and for epidermal growth
Autor:
J M, Jessup, G E, Gallick
Publikováno v:
Current problems in cancer. 16(5)
Rapid progress in understanding the biology of colorectal carcinoma has occurred in the last decade. During this time, the importance of tumor suppressor genes has been delineated. Mutations in proto-oncogenes, and some of the genetic and epigenetic
Autocrine growth stimulation by transforming growth factor-alpha in human non-small cell lung cancer
Autor:
P. A. Steck, A. F. Gazdar, N. Yen, G. E. Gallick, Jack A. Roth, Elizabeth A. Putnam, Kang Fang, B. Akpakip
Publikováno v:
Surgical oncology. 1(1)
We studied the biological response to and production of transforming growth factor-alpha (TGF-alpha) by the non-small cell lung carcinoma (NSCLC) clonal cell lines H226b, H322a, H460a, H596b. Each of these cell lines expressed epidermal growth factor