Zobrazeno 1 - 10
of 86
pro vyhledávání: '"G E, Bigelow"'
Publikováno v:
Psychopharmacology. 123:15-25
The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated
Publikováno v:
American Journal of Public Health. 84:207-210
OBJECTIVES. Intravenous drug users are at high risk for medical illness, yet many are medically underserved. Most methadone treatment programs have insufficient resources to provide medical care. The purpose of this study was to test the efficacy of
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(1)
Preclinical studies have demonstrated that kappa-opioid agonists can attenuate the neurochemical and behavioral effects of cocaine that are related to its reinforcing efficacy, suggesting that kappa-agonists may serve as pharmacotherapies for cocaine
Publikováno v:
Experimental and clinical psychopharmacology. 9(3)
The study tested a voucher-based abstinence reinforcement procedure for reducing opiate and cocaine use in a population of treatment-resistant opiate- and cocaine-abusing methadone patients. Vouchers exchangeable for goods and services were contingen
Autor:
K L, Preston, G E, Bigelow
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(1)
The purpose of this study was to examine the discrimination of agonist-antagonist opioids in humans trained in a two-choice hydromorphone/not hydromorphone discrimination. Eight adult male volunteers with histories of opioid abuse who were not curren
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(3)
The discriminative stimulus and subjective effects of opioid mixed agonist-antagonists were assessed in volunteer nondependent heroin users trained in a three-choice drug discrimination procedure to discriminate among the effects of i.m. administrati
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
levo-alpha-Acetylmethadol (LAAM) and methadone are full mu-opioid agonists used to treat opioid dependence. Current labeling indicates that LAAM is less potent than methadone. Clinical studies have not determined the relative potency of these drugs.
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(1)
Levo-alpha-acetylmethadol (LAAM) is a long-acting opioid agonist approved for use as a maintenance treatment for opioid dependence. Previous clinical studies report that the onset of the effects of LAAM is slower after parenteral administration than
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(2)
Levo-alpha-acetylmethadol (LAAM) currently is approved as an opioid maintenance treatment. This double-blind study was designed to characterize withdrawal suppression and opioid blockade produced by two different LAAM maintenance doses. Outpatient op
Autor:
T, Eissenberg, G E, Bigelow, E C, Strain, S L, Walsh, R K, Brooner, M L, Stitzer, R E, Johnson
Publikováno v:
JAMA. 277(24)
To compare the clinical efficacy of different doses of levomethadyl acetate hydrochloride (known as LAAM) in the treatment of opioid dependence.A randomized controlled, double-blind, parallel group, 17-week study.Outpatient facilities at Johns Hopkin