Zobrazeno 1 - 10
of 24
pro vyhledávání: '"G David, Young"'
Autor:
Johannes Dworzak, Daniel G. Rudmann, Famke Aeffner, Kristin Wilson, Crystal Faelan, Suzanne Kanaly, Manish Ranjitkar, Holger Lange, J Kris Piper, Steven A. Moore, Joshua C. Black, Anthony J. Milici, D. Frank, Jay S. Charleston, G. David Young, Alexander Moody
Publikováno v:
Archives of Pathology & Laboratory Medicine. 143:197-205
Context.—Duchenne muscular dystrophy is a rare, progressive, and fatal neuromuscular disease caused by dystrophin protein loss. Common investigational treatment approaches aim at increasing dystrophin expression in diseased muscle. Some clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa97caf1d30455e7d3a4039784629695
https://doi.org/10.5858/arpa.2017-0536-oa
https://doi.org/10.5858/arpa.2017-0536-oa
Autor:
Frederick J. Schnell, Amy Flynt, Jessie Lynch, Helen Eliopoulos, Cas Donoghue, Linda Lowes, Jerry R. Mendell, Anthony J. Milici, Emily Naughton, D. Frank, Sarah Lewis, Johannes Dworzak, Karin Lucas, Zarife Sahenk, Robert Dracker, Linda H. Cripe, Jay S. Charleston, G. David Young, Anne M. Connolly, Lindsay N. Alfano, Louise R. Rodino-Klapac
Publikováno v:
Medicine
This analysis aims to describe the outcomes of two nonambulatory patients with Duchenne muscular dystrophy (DMD) who participated in two clinical studies. The two consecutive trials of eteplirsen (studies 201 and 202) were conducted in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a723d5cf41ea1e9e860c4bea7d51813a
https://pubmed.ncbi.nlm.nih.gov/31261494
https://pubmed.ncbi.nlm.nih.gov/31261494
Autor:
Lei Chen, Bruce M. Wentworth, Uditha DeAlwis, G. David Young, Anthony J. Milici, Johannes Dworzak, D. Frank, Sarah Lewis, Frederick J. Schnell, Jerry R. Mendell, Jay S. Charleston, Louise R. Rodino-Klapac, Zarife Sahenk, Jon Voss, Cas Donoghue
Publikováno v:
Neurology. 90(24)
ObjectiveTo describe the quantification of novel dystrophin production in patients with Duchenne muscular dystrophy (DMD) after long-term treatment with eteplirsen.MethodsClinical study 202 was an observational, open-label extension of the randomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff8a7c05ed4d9b8607d4fa16b0ae489
https://pubmed.ncbi.nlm.nih.gov/30249679
https://pubmed.ncbi.nlm.nih.gov/30249679
Autor:
Jay S. Charleston, G. David Young, Kristin Wilson, Daniel G. Rudmann, Jon Tinsley, Crystal Faelan, Steven A. Moore, Anthony J. Milici, D. Frank, Janet C. Patterson-Kane
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are neuromuscular disorders that primarily affect boys due to an X-linked mutation in the DMD gene, resulting in reduced to near absence of dystrophin or expression of truncated fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd011661252ff27fbe18cfc203f5f1e
https://europepmc.org/articles/PMC5788182/
https://europepmc.org/articles/PMC5788182/
Autor:
Famke Aeffner, Dan Rudmann, Brad Bolon, Kristin Wilson, Charles R. Mahrt, Suzanne Kanaly, G. David Young, Elaine Charles
Publikováno v:
Toxicologic pathology. 44(6)
Historically, pathologists perform manual evaluation of H&E- or immunohistochemically-stained slides, which can be subjective, inconsistent, and, at best, semiquantitative. As the complexity of staining and demand for increased precision of manual ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7965ddb49b36337c53c96f31360825ee
https://pubmed.ncbi.nlm.nih.gov/27343178
https://pubmed.ncbi.nlm.nih.gov/27343178
Autor:
Famke Aeffner, G. David Young, Maryam Jangani, Mirza Peljto, Joseph S. Krueger, Joshua C. Black, Justin K Major, Michael O Ports, Nathan T. Martin
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 96(12)
Tissue image analysis (tIA) is emerging as a powerful tool for quantifying biomarker expression and distribution in complex diseases and tissues. Pancreatic ductal adenocarcinoma (PDAC) develops in a highly complex and heterogeneous tissue environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5701b87d11fb75743523e535adffb63
https://pubmed.ncbi.nlm.nih.gov/27775692
https://pubmed.ncbi.nlm.nih.gov/27775692
Autor:
Jerry R. Mendell, Louise R. Rodino-Klapac, Zarife Sahenk, Jay S. Charleston, G. David Young, Ellyn Peterson, Jon Voss, Kimberly M. Shontz, S. Lewis, Frederick J. Schnell, Famke Aeffner, Johannes Dworzak, Cas Donoghue, Steven A. Moore, Anthony J. Milici, D. Frank
Publikováno v:
European Journal of Paediatric Neurology. 21:e93-e94
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3620472b0ba0bfb5e85801594458377d
https://doi.org/10.1016/j.ejpn.2017.04.1209
https://doi.org/10.1016/j.ejpn.2017.04.1209
Inducible expression of TGFβ, Snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model
Autor:
Julie L.C. Kan, Stuart Thomson, David Epstein, Joseph S. Krueger, Maryland Rosenfeld-Franklin, Regina Sennello, John D. Haley, G. David Young, Peter Mercado, Jonathan A. Pachter, Krista Carey, Matthew O'Connor, Robert A. Wild, Stacia Silva, Gretchen M. Argast, Iain J. Mulford, Isabela Sujka-Kwok
Publikováno v:
Clinical & Experimental Metastasis. 28:593-614
The progression of cancer from non-metastatic to metastatic is the critical transition in the course of the disease. The epithelial to mesenchymal transition (EMT) is a mechanism by which tumor cells acquire characteristics that improve metastatic ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4039a3449958945f139ca1e267a71232
https://doi.org/10.1007/s10585-011-9394-8
https://doi.org/10.1007/s10585-011-9394-8
Publikováno v:
Drug Discovery Today. 15:943-950
The decision to advance an early-stage compound into formal preclinical testing depends on confidence in mechanism, efficacy and toxicity profiles. A substantial percentage of this confidence comes from histopathology interpretation, as the local tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4b0798418ec752c1156c04ee5a0948
https://doi.org/10.1016/j.drudis.2010.09.001
https://doi.org/10.1016/j.drudis.2010.09.001
Publikováno v:
Cancer Research. 78:5684-5684
Abstract: Introduction: Immune cell clustering is commonly observed in histopathology images. As the frequency and nature of immune cell clustering may represent biological phenomenon critical to response to immunotherapy, it is an import feature to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea5be2ec8a10e9f1a10fca9e90348ff
https://doi.org/10.1158/1538-7445.am2018-5684
https://doi.org/10.1158/1538-7445.am2018-5684