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Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking

Autor: Theo N. Kirkland, Peter S. Tobias, T Kuus-Reichel, Richard J. Ulevitch, Semi Kim, F K Multer, G D Virca

Publikováno v: Journal of Biological Chemistry. 265:9520-9525

A radioiodinated, photoactivatable derivative of Salmonella minnesota Re595 lipopolysaccharide (LPS) was used to label LPS-binding proteins in 70Z/3 cells. The labeled proteins were resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2660adfdc7040863d0350c6653803c0
https://doi.org/10.1016/s0021-9258(19)38880-5

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Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages

Autor: John C. Mathison, E Wolfson, Richard J. Ulevitch, Peter S. Tobias, G D Virca, Keith B. Glaser

Publikováno v: Journal of Clinical Investigation. 85:1108-1118

These experiments provide an explanation for the observation that two intravenous injections of lipopolysaccharide (LPS) spaced 5 h apart in rabbits cause tumor necrosis factor/cachectin (TNF) levels to rise in the blood only after the first LPS inje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6806be053ba210eaa1edd05112318e9
https://doi.org/10.1172/jci114542

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Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase

Autor: T A, Bird, J M, Kyriakis, L, Tyshler, M, Gayle, A, Milne, G D, Virca

Publikováno v: The Journal of biological chemistry. 269(50)

In KB epidermoid cells, we previously showed that interleukin-1 alpha (IL-1) and various mitogens activate the mitogen-activated protein (MAP) kinases ERK1 and ERK2, which phosphorylate both myelin basic protein (MBP) and a peptide containing Thr669

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e117cb7a659fa3660a0c80219d19d5a
https://pubmed.ncbi.nlm.nih.gov/7527398

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Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases

Autor: T A, Bird, P R, Sleath, P C, deRoos, S K, Dower, G D, Virca

Publikováno v: The Journal of biological chemistry. 266(33)

In this study we describe the activation of a protein kinase which phosphorylates a peptide, T669, comprising amino acids 663-681 of the epidermal growth factor receptor and containing the phosphate acceptor site Pro-Leu-Thr669-Pro. In the human epid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cff357957d28e488e1886ab433c8eece
https://pubmed.ncbi.nlm.nih.gov/1658005

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The proteolytic activation of interleukin-1 beta

Autor: R, Black, S, Kronheim, P, Sleath, T, Greenstreet, G D, Virca, C, March, T, Kupper

Publikováno v: Agents and actions. Supplements. 35

Interleukin-1 beta (IL-1 beta) is released from an inactive precursor by a proteolytic cleavage. A monocytic protease has been identified that appears to be involved in the physiological activation of this cytokine. Two situations have been found in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c9b0c0b11f4aa3c9f486b902dddaab7
https://pubmed.ncbi.nlm.nih.gov/1781425

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Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking

Autor: T N, Kirkland, G D, Virca, T, Kuus-Reichel, F K, Multer, S Y, Kim, R J, Ulevitch, P S, Tobias

Publikováno v: The Journal of biological chemistry. 265(16)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4bfb4cef780104ae4a77ca28f2387be
https://pubmed.ncbi.nlm.nih.gov/2345180

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Simplified northern blot hybridization using 5% sodium dodecyl sulfate

Autor: G D, Virca, W, Northemann, B R, Shiels, G, Widera, S, Broome

Publikováno v: BioTechniques. 8(4)

We describe a simplified Northern blot hybridization procedure. This procedure eliminates the need for many reagents commonly used in RNA hybridization and replaces them with two buffers containing 5% sodium dodecyl sulfate for pre-hybridization, hyb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6d013131239cd4a7b96d3cee7d6704a
https://pubmed.ncbi.nlm.nih.gov/1692715

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Lipopolysaccharide Induces Hyporesponsiveness to Its Own Action in RAW 264.7 Cells

Autor: Richard J. Ulevitch, S Y Kim, Keith B. Glaser, G D Virca

Publikováno v: Journal of Biological Chemistry. 264:21951-21956

Bacterial endotoxin (lipopolysaccharide, LPS) has the property of inducing hyporesponsiveness or tolerance to its own effects. This phenomenon has been demonstrated in man and experimental animals. The cellular changes that contribute to LPS toleranc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b5e7ec33b5abda168ec8284f1879dee
https://doi.org/10.1016/s0021-9258(20)88277-5

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Kinetics of association of human proteinases with human alpha 2-macroglobulin

Autor: J Travis, G D Virca

Publikováno v: Journal of Biological Chemistry. 259:8870-8874

Association rates have been determined for the interaction of human alpha 2-macroglobulin with human neutrophil elastase, cathepsin G, and human plasma kallikrein. Both of the neutrophil enzymes are rapidly inactivated by this inhibitor; however, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bec25af251a9b340eaad6a4339743390
https://doi.org/10.1016/s0021-9258(17)47234-6

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