Výsledky vyhledávání - "G D Van Der Spuy"

Tuberculosis research in South Africa over the past 30 years: From bench to bedside

Autor: P. D. van Helden, Andreas H. Diacon, Michele A. Miller, G D Van der Spuy, Novel N. Chegou, Rob Warren, Craig J. Kinnear, Stephanus T. Malherbe, Gerhard Theron, N Ismail, Gerhard Walzl, Wynand J. Goosen

Publikováno v: South African Medical Journal. 109:45

The South African Medical Research Council Centre for Tuberculosis Research has a rich history of high-impact research that has influenced our understating of this hyper-epidemic which is further exacerbated by the emergence and spread of drug-resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80167ca02ff9534ff3508f733e5b008
https://doi.org/10.7196/samj.2019.v109i11b.14249

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Discordance between Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat Typing and IS 6110 Restriction Fragment Length Polymorphism Genotyping for Analysis of Mycobacterium tuberculosis Beijing Strains in a Setting of High Incidence of Tuberculosis

Autor: Robin M. Warren, P. D. van Helden, K. G. P. Hoek, N. C. Gey van Pittius, A. M. Jordaan, Ndabambi S, T. C. Victor, Madeleine Hanekom, G. D. van der Spuy, McEvoy Cr

Publikováno v: Journal of Clinical Microbiology. 46:3338-3345

IS 6110 restriction fragment length polymorphism (RFLP) genotyping is the most widely used genotyping method to study the epidemiology of Mycobacterium tuberculosis . However, due to the complexity of the IS 6110 RFLP genotyping technique, and the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a9a7f40050e19bb760af28fa3f23481
https://doi.org/10.1128/jcm.00770-08

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A Recently Evolved Sublineage of the Mycobacterium tuberculosis Beijing Strain Family Is Associated with an Increased Ability to Spread and Cause Disease

Autor: Robin M. Warren, G. D. van der Spuy, McEvoy Cr, Hanekom M, T. C. Victor, Ndabambi S, P. D. van Helden, Elizabeth M. Streicher, Nulda Beyers, Martin Kidd

Publikováno v: Journal of Clinical Microbiology. 45:1483-1490

This study aimed to reconstruct the evolutionary history of Beijing strains of Mycobacterium tuberculosis and to test the hypothesis that evolution has influenced the ability of the Beijing strains within the different Beijing sublineages to spread a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac99dba44fa2fe75829264c7d2c396a
https://doi.org/10.1128/jcm.02191-06

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Clonal Expansion of a Globally Disseminated Lineage of Mycobacterium tuberculosis with Low IS 6110 Copy Numbers

Autor: Streicher Em, Tommie C. Victor, M. Richardson, P. D. van Helden, Philip Supply, G. D. van der Spuy, Violet N. Chihota, Robin M. Warren, Rabia Johnson, Camille Locht

Publikováno v: Journal of Clinical Microbiology. 42:5774-5782

Knowledge of the clonal expansion of Mycobacterium tuberculosis and accurate identification of predominant evolutionary lineages in this species remain limited, especially with regard to low-IS 6110- copy-number strains. In this study, 170 M. tubercu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ba47f9621c82f51734208260eba45a
https://doi.org/10.1128/jcm.42.12.5774-5782.2004

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Genotypic and Phenotypic Characterization of Drug-Resistant Mycobacterium tuberculosis Isolates from Rural Districts of the Western Cape Province of South Africa

Autor: Streicher Em, Thomas C. Victor, John Simpson, Kewley C, G. D. van der Spuy, Nalin Rastogi, Christophe Sola, Robin M. Warren, P. D. van Helden

Publikováno v: Journal of Clinical Microbiology. 42:891-894

Genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberculosis isolates from the Western Cape Province of South Africa showed that drug resistance is widespread and recently transmitted. Multidrug-resistant (MDR) isolates comprise 40%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b69d7c25205e3ff05d2926c9a8e2746
https://doi.org/10.1128/jcm.42.2.891-894.2004

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Molecular Analysis of Clinical Isolates of Mycobacterium tuberculosis Collected from Patients with Persistent Disease in the Khartoum Region of Sudan

Autor: Robin M. Warren, P. D. van Helden, Jordaan Am, Tommie C. Victor, G.S. Sharaf-Eldin, M.E. Hamid, N.S. Saeed, G. D. van der Spuy

Publikováno v: Journal of Infection. 44:244-251

Setting : Patients with positive smears for acid-fast bacilli were enrolled at tuberculosis (TB) clinics in the Khartoum region of Sudan. Objective : To identify the presence of drug resistant genotypes in M. tuberculosis isolates which are difficult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58f849e8e7e3791d2d15137c2d53519
https://doi.org/10.1053/jinf.2001.0992

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Evolution of the IS 6110- Based Restriction Fragment Length Polymorphism Pattern during the Transmission of Mycobacterium tuberculosis

Autor: Robin M. Warren, P. D. van Helden, C N Booysen, Marcel A. Behr, Nulda Beyers, M. Richardson, G. D. van der Spuy

Publikováno v: Journal of Clinical Microbiology. 40:1277-1282

Interpretation of the molecular epidemiological data of Mycobacterium tuberculosis is dependent on the validity of the assumptions that have been made. It is assumed that the IS 6110 banding pattern is sufficiently stable to define epidemiological ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394ebd610ef06411647a5fbf1a5cb0e3
https://doi.org/10.1128/jcm.40.4.1277-1282.2002

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Calculation of the stability of the IS6110 banding pattern in patients with persistent Mycobacterium tuberculosis disease

Autor: M. Richardson, Nulda Beyers, Martien W. Borgdorff, Robin M. Warren, P. D. van Helden, Marcel A. Behr, G. D. van der Spuy

Publikováno v: Journal of clinical microbiology, 40(5), 1705-1708. American Society for Microbiology

The interpretation of molecular epidemiologic data of Mycobacterium tuberculosis infection is dependent on the understanding of the stability and evolutionary characteristics of the DNA fingerprinting marker used to classify clinical isolates. This s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413aab926e407b02ccd37f8da6f03b19
https://doi.org/10.1128/jcm.40.5.1705-1708.2002

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Mapping of IS6110 flanking regions in clinical isolates of Mycobacterium tuberculosis demonstrates genome plasticity

Autor: M. Richardson, Robin M. Warren, G. D. van der Spuy, Carl Lombard, Samantha L. Sampson, Tommie C. Victor, P. D. van Helden

Publikováno v: Molecular Microbiology. 37:1405-1416

Southern hybridization was used in combination with IS6110 insertion-locus-specific probes in a comparative study to determine the structure of chromosomal domains flanking IS6110 elements in clinical isolates of Mycobacterium tuberculosis. The resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc70c17503efc13187224cb0572f532
https://doi.org/10.1046/j.1365-2958.2000.02090.x

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