Zobrazeno 1 - 10
of 110
pro vyhledávání: '"G D Roodman"'
Autor:
Jolene J. Windle, Jan H. Beumer, G. D. Roodman, Jumpei Teramachi, Rentian Feng, Julie L. Eiseman, W. Zhao, Noriyoshi Kurihara, Peng Yang, Rebecca Silbermann, Khalid S. Mohammad, Dan Zhou, Judith L. Anderson, Xiang-Qun Xie, Jianxia Guo, Kyaw Z. Myint, N. Maertz
Publikováno v:
Leukemia
We reported that p62 (sequestosome 1) serves as a signaling hub in bone marrow stromal cells (BMSCs) for the formation of signaling complexes, including NFκB, p38MAPK and JNK, that are involved in the increased osteoclastogenesis and multiple myelom
Autor:
Abraham P. Zimelman, Nikhil C. Munshi, Paulette Mehta, Rao Prabhala, Alan Lichtenstein, Caroline Behler, Catherine Klein, Terrence Grady, Yvonne A. Efebera, Saem Lee, Teresa G. Hayes, Abid Mohiuddin, Suman Kambhampati, Michal G. Rose, Sarvari Venkata Yellapragada, Andrew J Han, Antoun Houranieh, G. D. Roodman, Saulius K. Girnius
Publikováno v:
British Journal of Haematology. 169:36-43
Summary Once-weekly administration of bortezomib has reduced bortezomib-induced peripheral neuropathy without affecting response rates, but this has only been demonstrated prospectively in three- and four- drug combinations. We report a phase II tria
Autor:
Lilian I. Plotkin, G D Roodman, S A Kuhstoss, Teresita Bellido, Judith L. Anderson, Jesus Delgado-Calle, Meloney Cregor, K W Condon
Publikováno v:
Leukemia
Multiple myeloma (MM) causes lytic bone lesions due to increased bone resorption and concomitant marked suppression of bone formation. Sclerostin (Scl) levels, an osteocyte-derived inhibitor of Wnt/β-catenin signaling, are elevated in MM patient ser
Autor:
Rentian Feng, Tao Cheng, Peng Yang, Mohammed H. Alqarni, Haiping Cao, Noriyoshi Kurihara, Patrick Bartlow, Yingdai Gao, Kyaw-Zeyar Myint, Jürg Gertsch, Abdulrahman A. Almehizia, Jumpei Teramachi, Qin Tong, Xiang-Qun Xie, Lirong Wang, G. D. Roodman
Publikováno v:
Journal of Medicinal Chemistry. 55:9973-9987
N,N'-((4-(Dimethylamino)phenyl)methylene)bis(2-phenylacetamide) was discovered by using 3D pharmacophore database searches and was biologically confirmed as a new class of CB(2) inverse agonists. Subsequently, 52 derivatives were designed and synthes
Autor:
W. Zhao, Gaetano Donofrio, Pier Giorgio Petronini, Eugenia Martella, Nicoletta Campanini, Rebecca Silbermann, Cristina Mancini, Valentina Ferri, Luca Agnelli, Elena Fiorini, Irma Airoldi, Antonino Neri, Douglas M. Noonan, Marina Bolzoni, G. D. Roodman, Judith L. Anderson, Nicola Giuliani, Paola Storti, Katia Todoerti, Valentina Marchica, Daniela Guasco, Franco Aversa
Publikováno v:
Leukemia. 30(12)
Galectin-1 (Gal-1) is involved in tumoral angiogenesis, hypoxia and metastases. Actually the Gal-1 expression profile in multiple myeloma (MM) patients and its pathophysiological role in MM-induced angiogenesis and tumoral growth are unknown. In this
Autor:
E. A. Wang, T. J. Kuehl, B. R. MacDonald, E. R. Stanley, Gregory R. Mundy, S. Clark, G. D. Roodman
Publikováno v:
Journal of Bone and Mineral Research. 1:227-233
Several studies have suggested that the osteoclast is derived from a mononuclear precursor which is found in bone marrow. We have developed a system for studying the formation of osteoclast-like multinucleated cells in long-term bone marrow culture o
Publikováno v:
Journal of Bone and Mineral Research. 11:150-159
Autor:
G. D. Roodman
Publikováno v:
Journal of Bone and Mineral Research. 7:475-478
Autor:
Jian Q. Feng, John Tim Wright, Naoto Haruyama, K. Amin, Sun Jin Choi, Thomas C. Hart, P. S. Hart, G. D. Roodman, In Sun Song
Publikováno v:
Developmental Biology. 325(1):129-137
Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX
Publikováno v:
Reviews in Endocrine and Metabolic Disorders. 2:195-201
Paget's disease is a chronic focal disease of the skeleton that affects up to 2-3% of the population over the age of 60 years. There is a genetic predisposition for Paget's disease, with one predisposition locus identified on chromosome 18q-21-22. Os