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Studies of the K(ATP) channel opening activity of the new dihydropyridine compound 9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione in bladder detrusor in vitro

Autor: J H, Li, G D, Yasay, S T, Kau, C J, Ohnmacht, D A, Trainor, A D, Bonev, T J, Heppner, M T, Nelson

Publikováno v: Arzneimittel-Forschung. 46(5)

The potassium (K+) channel opening activity of ZM244085 (9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione, CAS 149398-59-4), a novel dihydropyridine (DHP), was ascertained. In a set of functional assays, its mechanoinhibitory effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4eed64517e1a8186c2a6136696f6b14
https://pubmed.ncbi.nlm.nih.gov/8737640

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Hemodynamic effects of adenosine agonists in the conscious spontaneously hypertensive rat

Autor: R L, Webb, R B, McNeal, B W, Barclay, G D, Yasay

Publikováno v: The Journal of pharmacology and experimental therapeutics. 254(3)

The present studies examined the underlying hemodynamic mechanisms contributing to the reduction in blood pressure observed in conscious spontaneously hypertensive rats after systemic administration of adenosine agonists. The effects produced by i.v.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09092d328eb5eab4cc83f77e1ee759f0
https://pubmed.ncbi.nlm.nih.gov/2203898

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Studies of the KATP Channel Opening Activity of the New Dihydropyridine Compound 9-(3-Cyanophenyl)-3,4,6,7,9,10-Hexahydro-1,8-(2H, 5H)-Acridinedione in Bladder Detrusor In Vitro

Autor: J. H. Li, G. D. Yasay, S. T. Kau, C. J. Ohnmacht, D. A. Trainor, A. D. Bonev, T. J. Heppner, M. T. Nelson

Publikováno v: The Journal of Urology. :2264

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4405053c6a81717d9f7e30b0cf7fb337
https://doi.org/10.1097/00005392-199806000-00212

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Degradation of atrial natriuretic peptide: pharmacologic effects of protease EC 24.11 inhibition

Autor: Zimmerman Mb, G D Yasay, Randy L. Webb, McMartin C, R B McNeal

Publikováno v: Journal of cardiovascular pharmacology. 14(2)

Several processes participate in the clearance of atrial natriuretic peptide (ANP) from the circulation, one of which is enzymatic degradation. Endoprotease EC 3.4.24.11 (NEP 24.11), present within the kidney in high concentration, has been shown in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a97a1bd5105be11db014b052ad9568
https://pubmed.ncbi.nlm.nih.gov/2476603

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