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pro vyhledávání: '"G C White nd"'
Publikováno v:
Thrombosis and Haemostasis. 77:660-667
SummaryA prospective, open-label multicenter investigation has been conducted to compare pharmacokinetic parameters of recombinant DNA-derived FVIII (rFVIII) and plasma-derived FVIII concentrate (pdFVIII) and to assess safety and efficacy of long-ter
Publikováno v:
Journal of Biological Chemistry. 265:19405-19408
rap1B is a member of the ras superfamily of low molecular weight GTP binding proteins which constitutes a focal point of GTP and cAMP signal transduction systems. Like other members of this superfamily, rap1B is membrane-associated in resting platele
Autor:
E Schwartz, Susan T. Lord, A B Zimrin, Joel S. Bennett, S Gidwitz, G C White nd, Mortimer Poncz
Publikováno v:
Journal of Biological Chemistry. 265:8590-8595
The platelet membrane glycoprotein (GP) IIb/IIIa complex, a member of the integrin family of adhesive receptors involved in cell-cell and cell-matrix interactions, contains binding sites for fibrinogen, von Willebrand factor, fibronectin, and vitrone
Publikováno v:
Journal of Biological Chemistry. 260:8996-9001
Proteolytic digestion and indirect immunostaining were used to compare the platelet and sarcoplasmic reticulum Ca2+-ATPase proteins. When the platelet and sarcoplasmic reticulum Ca2+-ATPase proteins were digested in the native state with trypsin, the
Publikováno v:
Journal of Clinical Investigation. 82:739-743
Human platelets are derived from megakaryocytes as anucleate cells, and thus contain only vestigial amounts of RNA capable of being transcribed into protein. This has greatly hampered efforts to study directly platelet-specific gene products and thei
Publikováno v:
Journal of Biological Chemistry. 252:7118-7123
Highly purified alpha-thrombin has been chemically modified in an attempt to determine which features of the molecule are important for normal platelet-thrombin interactions. Modifying agents included diisopropylphosphorofluoridate and 1-chloro-3-tos
Publikováno v:
Thrombosis and Haemostasis. 38:0514-0523
SummaryBleeding episodes in patients with hemophilia A with anti-factor VIII antibodies are frequently difficult to treat. Factor VIII concentrates administered by continuous infusion or prothrombin complex concentrates (PCC) have been used for treat