Zobrazeno 1 - 10
of 49
pro vyhledávání: '"G C Le Breton"'
Publikováno v:
European Journal of Medicinal Chemistry. 30:321-326
Summary The title compounds have been synthesized and their in vitro thromboxane A2 (TxA2) receptor antagonist activity evaluated. Both cis and trans isomers (1, 2) were shown to specifically inhibit submaximal human platelet aggregation induced by 2
Autor:
J. P. Dieter, G C Le Breton, E G Anderson, Dimitri Komiotis, C. T. Lim, Catherine Borg, David C. Yeomans
Publikováno v:
Journal of Biological Chemistry. 269:6109-6116
In the present study, a new polyclonal antibody (TxAb) was raised against native thromboxane A2 (TXA2)/prostaglandin H2 (PGH2) receptor protein. Previously developed anti-peptide antibodies (P1Ab, P2Ab) and TxAb were then used to prepare immunoaffini
Publikováno v:
Journal of Biological Chemistry. 268:26011-26017
The present study employed ligand affinity and immunoaffinity chromatography to isolate human platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor-coupled G-proteins. Purification of TXA2/PGH2 receptors by ligand (SQ31,491)-affinity chromato
Publikováno v:
ChemInform. 26
Publikováno v:
Journal of Medicinal Chemistry. 35:3033-3039
Previous observations implicating PgH2 as a direct activator of platelets suggested that derivatives of U46619, a well-characterized TxA2 receptor agonist having structural homology with PgH2, might possess antiplatelet activity. The present work des
Publikováno v:
Journal of Biological Chemistry. 267:6541-6547
We previously demonstrated that nonesterified as well as esterified eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) inhibit U46619-induced platelet aggregation and [3H]U46619 specific binding to washed human platelets. It was also
Publikováno v:
Journal of Biological Chemistry. 265:21692-21697
Human platelet lipids were enriched in vitro with different amounts of either docosahexaenoic acid (22:6n-3), eicosapentaenoic acid (20:5n-3) or linoleic acid (18:2n-6). Of the total fatty acid incorporated, between 82 and 95% was associated with the
Publikováno v:
Journal of neurochemistry. 78(3)
Previous reports have demonstrated the presence of functional thromboxane A2 (TP) receptors in astrocytes and oligodendrocytes. In these experiments, the presence and function of TP receptors in primary rat Schwann cells (rSC) and a neurofibrosarcoma
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 120
Autor:
M. Croset, Evelyne Véricel, G. C. Le Breton, Michel Lagarde, Catherine Calzada, Annie-France Prigent
Publikováno v:
Eicosanoids ISBN: 9781489902023
N-3 fatty acids are polyunsaturated ones that all derive from linolenic acid (18:3n-3) in animals. Together with linoleic acid (18:2n-6), that cannot be synthesized in animals, 18:3n-3 is considered as an essential fatty acid, especially in being the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0a2492cc7824421d0bf5eafa971070c
https://doi.org/10.1007/978-1-4899-0200-9_12
https://doi.org/10.1007/978-1-4899-0200-9_12