Výsledky vyhledávání - "G C, de Gast"

Radiofrequente ablatie gecombineerd met interleukine-2 induceert een antitumorrespons tegen het niercelcarcinoom

Autor: Laura G.M. Daenen, G. C. De Gast, S.G.C. Kroeze, Maarten W. Nijkamp, J.L.H.R. Bosch, Jeanine M.L. Roodhart, Judith J.M. Jans

Publikováno v: Tijdschrift voor Urologie. 2:136-143

Er is hernieuwde interesse voor immunotherapie als behandeling voor gemetastaseerd niercelcarcinoom (NCC). Deze studie had als doel te bepalen of radiofrequente ablatie (RFA) gecombineerd met interleukine-2 (IL-2) een tumorspecifieke immuunrespons ka

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4efbe1879ae59183caeea084ceec0829
https://doi.org/10.1007/s13629-012-0064-7

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Lack of anti-tumour reactivity despite enhanced numbers of circulating natural killer T cells in two patients with metastatic renal cell carcinoma

Autor: Axel Bex, C. J.C. van den Bogaard, J. J. Sein, J. B. A. G. Haanen, W. van de Kasteele, Trees A. M. Dellemijn, Florry A. Vyth-Dreese, W. J. Nooijen, G. C. De Gast

Publikováno v: Clinical and Experimental Immunology. 162:447-459

Summary Natural killer T (NK T) cells play a central role as intermediates between innate and adaptive immune responses important to induce anti-tumour reactivity in cancer patients. In two of 14 renal cell carcinoma (RCC) patients, treated with inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c452655ad03d70fbd59a2ab151ea73
https://doi.org/10.1111/j.1365-2249.2010.04274.x

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Extended Continuous Oral Temozolomide in Patients with Progressive Metastatic Renal Cell Carcinoma Not Responding to Interferon Alpha 2b

Autor: G. C. De Gast, H. Van Tinteren, Axel Bex, H. Mallo, J.M. Kerst, S. Horenblas

Publikováno v: Journal of Chemotherapy. 17:674-678

The aim of the study was to evaluate the toxicity and efficacy of oral extended continuous temozolomide in patients with progressive metastatic renal cell carcinoma (RCC) not responding to immunotherapy after removal of the primary tumor. Patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64d18136f1d2414dd310272278585f6
https://doi.org/10.1179/joc.2005.17.6.674

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Prolonged low dose IL-2 and thalidomide in progressive metastatic renal cell carcinoma with concurrent radiotherapy to bone and/or soft tissue metastasis: a phase II study

Autor: H. J. Teertstra, Axel Bex, J. M. Kerst, J. B. A. G. Haanen, H. Mallo, G. C. De Gast, Willem Boogerd, L. Dewit

Publikováno v: Cancer Immunology, Immunotherapy. 54:926-931

Metastatic renal cell cancer is one of the immuno-sensitive tumors. Apart from the immuno-modulating agents IFNalpha and IL-2, thalidomide has been reported to be effective in this type of cancer. However, bone metastases and bulky metastases, show l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6084bdee7b1ed55125c80cedd9f97feb
https://doi.org/10.1007/s00262-005-0677-2

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Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFNα in patients with metastatic melanoma

Autor: W. van de Kasteele, Florry A. Vyth-Dreese, D Batchelor, Omgo E. Nieweg, W. J. Nooijen, Willem Boogerd, M J Kersten, G. C. De Gast, M A de Waal, J. J. Sein

Publikováno v: British Journal of Cancer
British journal of cancer, 88(2), 175-180. Nature Publishing Group

The purpose of this study is to determine the toxicity and efficacy of temozolomide (TMZ) p.o. followed by subcutaneous (s.c.) low-dose interleukin-2 (IL2), granulocyte-monocyte colony stimulating factor (GM-CSF) and interferon-alpha 2b (IFN alpha) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bb5b3a36ace4ff11b9c3f491520037
http://europepmc.org/articles/PMC2377058

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The Role of Initial Immunotherapy as Selection for Nephrectomy in Patients with Metastatic Renal Cell Carcinoma and the Primary Tumor in Situ

Autor: G. C. De Gast, Simon Horenblas, Wim Meinhardt, Natascha Verra, Axel Bex

Publikováno v: European Urology. 42:570-576

Objective: A prospective pilot study in patients with metastatic renal cell cancer and the primary in situ to assess the feasibility of immunotherapy prior to nephrectomy and to evaluate the rationale for a future randomized trial to define the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411828280e86b2b7e19629645a8ef8e3
https://doi.org/10.1016/s0302-2838(02)00404-9

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Transferrin toxin but not transferrin receptor immunotoxin is influenced by free transferrin and iron saturation

Autor: W C Vooijs, P H Gosselaar, Letizia Polito, A F M Verheul, Joannes J.M. Marx, A J G van-Dijk, H G J Krouwer, G C de-Gast, Andrea Bolognesi

Publikováno v: European Journal of Clinical Investigation. 32:61-69

Background Cytotoxic agents can be targeted successfully to cancer cells. The efficacy of such novel and potent anticancer strategies may be influenced by variables of iron metabolism. Methods The in vitro cytotoxicity against glioma cells of transfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a06d64e3b74ff8f0ce197cd8a7150a1e
https://doi.org/10.1046/j.1365-2362.2002.0320s1061.x

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Reinfusion of Autologous Lymphocytes With Granulocyte-Macrophage Colony-Stimulating Factor Induces Rapid Recovery of CD4+ and CD8+ T Cells After High-Dose Chemotherapy for Metastatic Breast Cancer

Autor: G C, de Gast, F A, Vyth-Dreese, W, Nooijen, C J C, van den Bogaard, J, Sein, M M J, Holtkamp, G A M, Linthorst, J W, Baars, J H, Schornagel, S, Rodenhuis

Publikováno v: Journal of clinical oncology, 20(1), 58-64. American Society of Clinical Oncology

PURPOSE: Repeated high-dose chemotherapy (HDCT) followed by peripheral-blood progenitor cell (PBPC) transplantation can induce a complete remission in patients with metastatic breast cancer sensitive to standard chemotherapy (CT), but the majority of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb2eaa5433c0383e32b6c14a05dda03
https://doi.org/10.1200/jco.2002.20.1.58

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Determination of helper T-cell precursor frequencies against non-haemopoietic cells: comparison of co-stimulation provided by anti-CD28 antibody versus the cellular ligand B7-1

Autor: Simone A. E. Stadhouders-Keet, G. C. De Gast, R. A. W. Van Lier, Henderikus G. Otten, L. F. Verdonck, A.M.C. van Dijk, Floortje L. Kessler

Publikováno v: British Journal of Haematology. 110:322-326

Helper T-cell precursor frequency assays (HTLp-assays) are commonly used in transplantation to examine the frequency of T cells reactive against donor or host alloantigens. In these assays, peripheral blood mononuclear cells (PBMCs) are most often us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::906f7ccbb0228c732fa0778804044624
https://doi.org/10.1046/j.1365-2141.2000.02217.x

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Hepatocyte growth factor/scatter factor (HGF/SF) affects proliferation and migration of myeloid leukemic cells

Autor: Jean-Henri Bourhis, G. C. De Gast, Carlijn Voermans, N. Miranda, P. C. M. Van Den Berk, W. R. Gerritsen, Toshikazu Nakamura, I S Weimar

Publikováno v: Leukemia. 12:1195-1203

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is produced by mesenchymal cells, including bone marrow (BM) stromal cells, and has mitogenic and motogenic effects on a variety of cell types. Recently, a role has been assigned to H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c047798fee2085c0ce23cb1817fa7fa
https://doi.org/10.1038/sj.leu.2401080

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