Zobrazeno 1 - 10
of 15
pro vyhledávání: '"G C, Tucker"'
Autor:
Stéphane Léonce, V. Perez, Nicolas Guilbaud, Alain Pierré, A A Cordi, A D Morris, G C Tucker, Ghanem Atassi, M. Jan
Publikováno v:
Anti-Cancer Drugs. 8:746-755
The polyanionic species suramin is a potential anti-cancer agent of narrow therapeutic index. Among other pharmacological characteristics, suramin is an inhibitor of angiogenesis. We have targeted its angiostatic properties as part of a program to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade7612ebf236696d170b70b10c707f2
https://doi.org/10.1097/00001813-199709000-00003
https://doi.org/10.1097/00001813-199709000-00003
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 5(3)
Among the newer and promising weapons against cancer are Farnesyl Transferase Inhibitors (FTI). Indeed it is known that the enzyme Farnesyl Transferase (FT), catalyses the prenylation of cysteine residues of several proteins associated with cancer pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bef9b45fff0d8a92acecc87c2763ad5
https://pubmed.ncbi.nlm.nih.gov/19442210
https://pubmed.ncbi.nlm.nih.gov/19442210
Publikováno v:
Angiogenesis. 3(3)
The microenvironment of the majority of solid tumours in which new vessels must grow and survive is acidic. Whilst recent reports suggest a role of the low tumour pH in the invasive and metastatic potential of tumour cells, little is known as to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3de458923d541c024e469c608a85e2c2
https://pubmed.ncbi.nlm.nih.gov/14517427
https://pubmed.ncbi.nlm.nih.gov/14517427
Publikováno v:
Angiogenesis. 5(3)
Matrix metalloproteinases (MMPs) constitute a large family of extracellular matrix degrading proteases implicated in a number of physiological and pathological processes, including angiogenesis. However, the relative importance of the individual MMPs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::588bf4b3b26397c76b79fe0e5d9189c1
https://pubmed.ncbi.nlm.nih.gov/12831062
https://pubmed.ncbi.nlm.nih.gov/12831062
Autor:
G C, Tucker
Publikováno v:
Therapie. 56(5)
The multiplicity of experimental models of angiogenesis in vitro and in vivo complicates the choice of a straightforward strategy to accurately identify the anti-angiogenic potential of a natural or synthetic compound with antitumoral activity. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58d82e04cb9ae343ca5c741e8db71ab7
https://pubmed.ncbi.nlm.nih.gov/11806283
https://pubmed.ncbi.nlm.nih.gov/11806283
Autor:
J M, Henlin, J A, Boutin, N, Kucharczyk, C, Desmet-Beaufort, A, Loynel, M, Bertrand, A, Genton, G C, Tucker, G, Atassi, J L, Fauchére
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 57(2)
A complete 331,776-member library of tetrapeptides made of 24 amino acid building blocks was synthesized robotically on solid phase and subjected to a deconvolution based on the inhibitory potency of the sublibraries in a HPLC assay of the S-farnesyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b1f2299c2e701ecfd423804f82dd603
https://pubmed.ncbi.nlm.nih.gov/11168892
https://pubmed.ncbi.nlm.nih.gov/11168892
Autor:
David Ricol, Jean Paul Thiery, El Marjou A, G C Tucker, Ferry G, Yoshida T, François Radvanyi, Marie-France Poupon, Dominique K. Chopin, Girault Jm, Gil-Diez-de-Medina S, David Cappellen
Publikováno v:
Oncogene. 18(51)
FGFRs (fibroblast growth factor receptors) are encoded by four genes (FGFR1 – 4). Alternative splicing results in various receptor isoforms. The FGFR2-IIIb variant is present in a wide variety of epithelia, including the bladder epithelium. Recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c712e331afa543c9852ed045ca5c8
https://pubmed.ncbi.nlm.nih.gov/10602477
https://pubmed.ncbi.nlm.nih.gov/10602477
Publikováno v:
International journal of cancer. 68(5)
In situ changes in the repertoire of integrins and proteolytic enzymes have been demonstrated during melanoma metastasis. To investigate whether established human melanoma cell lines, injected into nude mice, could undergo phenotypic changes similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4a0bc3d56a2750546bb145b72d2bacc
https://pubmed.ncbi.nlm.nih.gov/8938149
https://pubmed.ncbi.nlm.nih.gov/8938149
Publikováno v:
Symposia of the Society for Experimental Biology. 47
Since one crucial step in tumor progression consists of the acquisition of invasive and metastatic properties, it is important to analyze the mechanisms used by cancer cells to disperse. Among the possible mechanisms of cell dispersion, cell motility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f82c239dd7865d70480fa760082e950
https://pubmed.ncbi.nlm.nih.gov/7513090
https://pubmed.ncbi.nlm.nih.gov/7513090
Publikováno v:
Cancer cells (Cold Spring Harbor, N.Y. : 1989). 3(12)
Tumor metastasis is associated with an increase in the plasticity of malignant cells, a phenomenon that is characterized by changes in cell morphology and a decrease in intercellular cohesiveness. The plasticity of cells is correlated with their moti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8199a685dc355c6d76e3cdf03ed20fdf
https://pubmed.ncbi.nlm.nih.gov/1840291
https://pubmed.ncbi.nlm.nih.gov/1840291