Zobrazeno 1 - 10
of 22
pro vyhledávání: '"G C, Todd"'
Publikováno v:
Veterinary and human toxicology. 36(4)
The toxicology of narasin has been extensively investigated in several species of laboratory animals. Acute median lethal po doses varied considerably between species (10 to 40.8 mg/kg). Animals of various species given acutely toxic doses of narasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6041c01127a16d6f7d9c626737725564
https://pubmed.ncbi.nlm.nih.gov/7975139
https://pubmed.ncbi.nlm.nih.gov/7975139
Publikováno v:
Teratology. 48(4)
Gemcitabine was given intravenously to female mice on gestation days (GD) 6-15 at doses of 0, 0.05, 0.25, or 1.5 mg/kg/day (0, 0.15, 0.75, or 4.5 mg/m2/day, respectively). Animals assigned to the teratology segment (25/group) were killed on GD 18 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c669d3e8c4c74058c52e98eda5a7d94
https://pubmed.ncbi.nlm.nih.gov/8278936
https://pubmed.ncbi.nlm.nih.gov/8278936
Publikováno v:
Cancer research. 50(14)
A new pyrimidine antimetabolite, 2',2'-difluorodeoxycytidine, Gemcitabine (LY188011, dFdCyd) has been synthesized and evaluated in experimental tumor models. dFdCyd is a very potent and specific deoxycytidine analogue. The concentration required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3765744e1b92ac6cbc10ed61618beacc
https://pubmed.ncbi.nlm.nih.gov/2364394
https://pubmed.ncbi.nlm.nih.gov/2364394
Publikováno v:
Veterinary Pathology. 16:722-729
Lymphocytic thyroiditis was induced in young Wistar rats by feeding them the immunosuppressive compound frentizole [1-(6-methoxy-2-benzothiazolyl)-3-phenyl urea] for 1 year. About half of the rats given 0.060 and 0.150% frentizole in the diet had lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c362847eb61712266411b1034aa158
https://doi.org/10.1177/030098587901600611
https://doi.org/10.1177/030098587901600611
Publikováno v:
Cancer treatment reports. 63(1)
Neurotoxicity is the major side effect occurring during the clinical use of vincristine (VCR). Animal models predictive of potential neurotoxicity would be very useful in the preclinical development of new vinca compounds. To simulate conditions in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c55865dfc63c695c15013454e5b3ddc
https://pubmed.ncbi.nlm.nih.gov/105807
https://pubmed.ncbi.nlm.nih.gov/105807
Publikováno v:
Food and cosmetics toxicology. 12(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce78a1e4bcc1233b6b1a26768f7d782d
https://pubmed.ncbi.nlm.nih.gov/4459242
https://pubmed.ncbi.nlm.nih.gov/4459242
Autor:
Gerald A. Poore, G. C. Todd, R. C. Hoying, R. L. Nelson, George Joseph Cullinan, R. L. Robison, Sweeney Mj, W. E. Jones, W. M. Newlon, Koert Gerzon, C. J. Barnett, R. W. Dyke
Publikováno v:
Journal of medicinal chemistry. 21(1)
Exploration of the effects of "minor" structural differences on the antitumor activity and toxicity of dimeric Catharanthus alkaloids resulted in the preparation of deacetylvinblastine amide (vindesine, VDS) from either vinblastine (VLB) or deacetylv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ac2d2ddd97a200c2729fc6e2711709
https://pubmed.ncbi.nlm.nih.gov/412968
https://pubmed.ncbi.nlm.nih.gov/412968
Publikováno v:
Veterinary pathology. 12(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9fc9a05c7082d0a750bf6b78d5c8b00
https://pubmed.ncbi.nlm.nih.gov/1166586
https://pubmed.ncbi.nlm.nih.gov/1166586
Publikováno v:
Journal of animal science. 58(6)
The toxicology of monensin has been studied in several laboratory animal species. There was considerable species variation in acute oral LD50 values. The consistent signs of acute toxicity were: anorexia, hypoactivity, skeletal muscle weakness, ataxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141e5792e6deb1452a549e50ca855df8
https://pubmed.ncbi.nlm.nih.gov/6746442
https://pubmed.ncbi.nlm.nih.gov/6746442
Autor:
Sweeney Mj, R. C. Hoying, R. L. Nelson, R. L. Robison, W. M. Newlon, George Joseph Cullinan, W. E. Jones, Koert Gerzon, Gerald A. Poore, R. W. Dyke, G. C. Todd, C. J. Barnett
Publikováno v:
Chemischer Informationsdienst. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed1de4bfec9729fb8d9c3367a6189a7f
https://doi.org/10.1002/chin.197820319
https://doi.org/10.1002/chin.197820319