Zobrazeno 1 - 10 of 53 pro vyhledávání: '"G C, Inglis"'
2
The Y Chromosome Effect on Blood Pressure in Two European Populations
Autor: Niall H. Anderson, Maciej Tomaszewski, Fadi J. Charchar, B Lacka, Alex McConnachie, G. C. Inglis, Anna F. Dominiczak, Sandosh Padmanabhan, Władysław Grzeszczak, Graham Watt, John M. C. Connell, Ewa Zukowska-Szczechowska, Mark N. Upton
Publikováno v: Hypertension. 39:353-356
Higher blood pressure (BP) in males compared with females is well documented and is thought to be influenced in part by the Y chromosome. To examine whether there is an association between BP and a polymorphic Hin dIII biallelic marker in the nonreco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5a55c2075c267434f51222a7513620
https://doi.org/10.1161/hy0202.103413
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3
An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects
Autor: E Friel, W. Stewart Hillis, Christine D. Holloway, Mary C. Ingram, G. C. Inglis, Lorna Swan, John M. C. Connell, Robert Fraser, Eleanor Davies
Publikováno v: Clinical Endocrinology. 54:813-817
OBJECTIVE Previous evidence suggests that the efficiency of 11β-hydroxylase is at least partly heritable and also that it may be mildly impaired in essential hypertension. In both cases, assessment of activity was based on the response of 11-deoxyco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88b09386f53300cb02e4cbbf2caeac4b
https://doi.org/10.1046/j.1365-2265.2001.01264.x
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4
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome)
Autor: E Friel, Eleanor Davies, Robert Fraser, John M. C. Connell, G. C. Inglis, Pierre F. Plouin
Publikováno v: Clinical Endocrinology. 54:725-730
OBJECTIVE The hypertension of Conn's syndrome is due to autonomous aldosterone production by a unilateral adrenocortical adenoma. The source of tumour initiation and the reasons for excess aldosterone production as opposed to cortisol are not known,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::561f5ee226157ae4dfe5fc2baf64a225
https://doi.org/10.1046/j.1365-2265.2001.01287.x
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6
Familial Pattern of Corticosteroids and Their Metabolism in Adult Human Subjects - the Scottish Adult Twin Study1
Autor: W. S. Hillis, Lorna Swan, Eleanor Davies, J. M. C. Connell, Mary C. Ingram, Christine D. Holloway, Robert Fraser, D. Birnie, G. C. Inglis
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 84:4132-4137
Corticosteroids are important in the regulation of normal physiology and are key factors in regulating cardiovascular physiology and disease, the development of which is known to have a genetic component. However, there is little information on the e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::799bf0e0f81caeeca87cae3991a58117
https://doi.org/10.1210/jcem.84.11.6146
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7
Aldosterone Excretion Rate and Blood Pressure in Essential Hypertension Are Related to Polymorphic Differences in the Aldosterone Synthase Gene CYP11B2
Autor: Eleanor Davies, Niall H. Anderson, Christine D. Holloway, John M. C. Connell, Caroline Morrison, Robert Fraser, Mary C. Ingram, G. C. Inglis, E Friel
Publikováno v: Hypertension. 33:703-707
Abstract —Significant correlation of body sodium and potassium with blood pressure (BP) may suggest a role for aldosterone in essential hypertension. In patients with this disease, the ratio of plasma renin to plasma aldosterone may be lower than i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d152787990d25ec0d58cdf264d74ae1
https://doi.org/10.1161/01.hyp.33.2.703
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8
Mechanisms by which the Hawksley random zero sphygmomanometer underestimates blood pressure and produces a non-random distribution of RZ values
Autor: G. C. Inglis, Anthony F. Lever, S. Kennedy, L. S. Murray, W. C. B. Brown
Publikováno v: Journal of Human Hypertension. 11:75-93
Four faults are reported in the Hawksley Random Zero Sphygmomanometer (RZS). Our study is of their mechanism. (i) Compared with a mercury sphygmomanometer the RZS underestimates blood pressure (BP). We confirm this: for 240 measurements by three expe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e1aa8ba9a0979c0e55a49a6738b9bc
https://doi.org/10.1038/sj.jhh.1000405
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9
Altered 11 beta-hydroxylase activity in glucocorticoid-suppressible hyperaldosteronism
Autor: Eleanor Davies, A. Jamieson, J. M. C. Connell, Mary C. Ingram, G. C. Inglis, Robert Fraser
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 81:2298-2302
Corticosteroid 11 beta-hydroxylation is catalyzed by 11 beta-hydroxylase and aldosterone synthase. Using plasma steroid ratios, the level of this process in patients with glucocorticoid-suppressible hyperaldosteronism (GSH) was compared with that in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c391c51cd57834a8009c94d25a3dd47
https://doi.org/10.1210/jcem.81.6.8964867
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10
Microsatellite polymorphism analysis allows the individual assignment of the rat 11β-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat × mouse somatic cell hybrids and identifies differences between and within various rat strains
Autor: Christopher J. Kenyon, Karin Klinga-Levan, R G Sutcliffe, G C Inglis, Claude Szpirer, John M. C. Connell
Publikováno v: Journal of Molecular Endocrinology. 14:303-311
Mouse hepatoma × rat hepatocyte hybrids that segregate rat chromosomes were used to determine the chromosomal location of the rat genes encoding 11 β-hydroxylase and aldosterone synthase (Cyp11b1 and Cyp11b2 respectively). By means of species-speci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0c0edbd4b020dec4e6341228055bf8
https://doi.org/10.1677/jme.0.0140303
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