Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression

Autor: Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene

Externí odkaz: https://doaj.org/article/c362f4cc95db4024a0d3eb4b310fffac

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

Autor: Billie G. C. Griffith, Rosanna Upstill-Goddard, Holly Brunton, Graeme R. Grimes, Andrew V. Biankin, Bryan Serrels, Adam Byron, Margaret C. Frame

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to contro

Externí odkaz: https://doaj.org/article/164998aec79f4674b257ec55ae3e2b20

Characterisation of a nucleo-adhesome

Autor: Adam Byron, Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex von Kriegsheim, Valerie G. Brunton, Margaret C. Frame

Publikováno v: Byron, A, Griffith, B G C, Herrero, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, Kriegsheim, A V, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications, vol. 13, no. 1, 3053 . https://doi.org/10.1038/s41467-022-30556-5
Byron, A, Griffith, B, Herrero Mier, A, Loftus, A E P, Koeleman, E S, Kogerman, L, Dawson, J C, McGivern, N, Culley, J, Grimes, G R, Serrels, B, von Kriegsheim, A, Brunton, V G & Frame, M C 2022, ' Characterisation of a nucleo-adhesome ', Nature Communications . https://doi.org/10.1038/s41467-022-30556-5

In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880df6d692ea82748eb2741b6d3df01e
https://pubmed.ncbi.nlm.nih.gov/35650196

USE OF ESTROGEN IN THE TREATMENT OF ATHEROSCLEROSIS AND ITS SEQUELAE--A TEN-YEAR STUDY

Autor: J, MARMORSTON, G C, GRIFFITH

Publikováno v: A listing of research in the cardiovascular field. 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1164441692d77ae70a49e6f070abf856
https://pubmed.ncbi.nlm.nih.gov/24547502

Problem of recurrence in rheumatic fever

Autor: C T, BINGHAM, G C, GRIFFITH

Publikováno v: United States naval medical bulletin. 46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e55fbaa9c6c6e5c632637b3c4ecbf7a
https://pubmed.ncbi.nlm.nih.gov/21012943