Zobrazeno 1 - 7
of 7
pro vyhledávání: '"G C, Fraizer"'
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(12 Pt 2)
Genital abnormalities associated with Wilms' tumors in the WAGR and Denys-Drash syndromes and the failure of the gonads to develop in Wilms' tumor gene (wt1)-homozygous mutant mice suggest that WT1 may also function in sexual development. To elucidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18b634ff4cce1994645438de685048e1
https://pubmed.ncbi.nlm.nih.gov/9815658
https://pubmed.ncbi.nlm.nih.gov/9815658
Publikováno v:
Leukemia. 10(7)
WT1 is a tumor suppressor gene that can repress transcription of many growth-factor and growth-factor receptor genes. We quantitated WT1 expression levels in 62 acute myelogenous leukemia (AML) samples and found that 82% strongly expressed WT1. WT1 e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8182f9d787547384af13f9eb74561944
https://pubmed.ncbi.nlm.nih.gov/8683991
https://pubmed.ncbi.nlm.nih.gov/8683991
Publikováno v:
The Journal of biological chemistry. 269(12)
The Wilms' tumor gene, WT1, is expressed in few tissues, mainly the developing kidney, genitourinary system, and mesothelium, and in immature hematopoietic cells. To develop an understanding of the role of WT1 in development and tumorigenesis, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a727cc949a882404bcf1443b0096a661
https://pubmed.ncbi.nlm.nih.gov/8132626
https://pubmed.ncbi.nlm.nih.gov/8132626
Publikováno v:
Human genetics. 83(4)
The most common deficiency allele of the protease inhibitor (PI) alpha 1-antitrypsin (alpha 1AT) is PI*Z. Other rare deficiency alleles of alpha 1AT are of two types: those producing low but detectable amounts of alpha 1AT (less than 20% of normal se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea8fa2d3dfed34ae53230ee49e6c139f
https://pubmed.ncbi.nlm.nih.gov/2807278
https://pubmed.ncbi.nlm.nih.gov/2807278
Publikováno v:
American journal of human genetics. 44(6)
A deficiency of the plasma protease inhibitor alpha 1-antitrypsin (alpha 1AT) is usually a consequence of the PI*Z allele. Mmalton is another deficiency allele which, like Z alpha 1AT, is associated with hepatocyte inclusions and impaired secretion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f8615cd8decbcd937ae569d23948325
https://pubmed.ncbi.nlm.nih.gov/2786335
https://pubmed.ncbi.nlm.nih.gov/2786335
Publikováno v:
Cancer research. 48(17)
The activation of platelet-derived growth factor (PDGF) production by transformed cells is often observed but not well understood. We have examined cell lines that showed "spontaneous" increases in PDGF secretion, i.e., in which the increase was not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d3d286eb1a3ff99fb3dc5f86a9e639c
https://pubmed.ncbi.nlm.nih.gov/2842041
https://pubmed.ncbi.nlm.nih.gov/2842041
Transcriptional regulation of the androgen signaling pathway by the Wilms' tumor suppressor gene WT1
Publikováno v:
Europe PubMed Central
The androgen-signaling pathway plays a critical role in prostate cancer development and progression. We have recently demonstrated that the Wilms' tumor suppressor gene product, WT1, binds to multiple sites in the androgen receptor (AR) promoter and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::346b2746450ea2f8056a1e90dae146d1
http://europepmc.org/abstract/med/11299720
http://europepmc.org/abstract/med/11299720
