Zobrazeno 1 - 10 of 181 pro vyhledávání: '"G Barsan"'
1
Akademický článek
Coagulation markers and functional outcome in acute ischemic stroke: Impact of intensive versus standard hyperglycemia control
Autor: Nina T. Gentile, A. Koneti Rao, Hannah Reimer, Fabiola Del Carpio‐Cano, Viswanathan Ramakrishnan, Qi Pauls, William G. Barsan, Askiel Bruno, for the iSPOT, Neurological Emergencies Treatment Trials Network (NETT) Investigators
Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 5, Pp n/a-n/a (2021)
Abstract Objective Alterations in coagulation could mediate functional outcome in patients with hyperglycemia after acute ischemic stroke (AIS). We prospectively studied the effects of intensive versus standard glucose control on coagulation markers
Externí odkaz: https://doaj.org/article/79235058a8934841b5b2c0e9c1d98efe
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2
An adaptive clinical trial design to identify the target dose of tenecteplase for treatment of acute pulmonary embolism
Autor: Sharon D Yeatts, Lydia D Foster, William G Barsan, Nicholas S Berry, Clifton W Callaway, Roger J Lewis, Benjamin R Saville, Robert Silbergleit, Jeffrey A Kline
Publikováno v: Clin Trials
Background/Aims Fibrinolytic therapy with tenecteplase has been proposed for patients with pulmonary embolism but the optimal dose is unknown. Higher-than-necessary dosing is likely to cause excess bleeding. We designed an adaptive clinical trial to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c583e814646e9b8c5a2cf7bfb80b228
https://doi.org/10.1177/17407745221105897
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3
Akademický článek
The life cycles of six multi-center adaptive clinical trials focused on neurological emergencies developed for the Advancing Regulatory Science initiative of the National Institutes of Health and US Food and Drug Administration: Case studies from the Adaptive Designs Accelerating Promising Treatments Into Trials Project
Autor: Timothy C Guetterman, Michael D Fetters, Samkeliso Mawocha, Laurie J Legocki, William G Barsan, Roger J Lewis, Donald A Berry, William J Meurer
Publikováno v: SAGE Open Medicine, Vol 5 (2017)
Objectives: Clinical trials are complicated, expensive, time-consuming, and frequently do not lead to discoveries that improve the health of patients with disease. Adaptive clinical trials have emerged as a methodology to provide more flexibility in
Externí odkaz: https://doaj.org/article/497b90f74e8e454493c15e33a86d4c7a
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5
Akademický článek
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7
Serum NfL (Neurofilament Light Chain) Levels and Incident Stroke in Adults With Diabetes Mellitus
Autor: Jeremy B. Sussman, Frederick K. Korley, William J. Meurer, Mitra Mastali, Jennifer E. Van Eyk, Deborah A. Levine, Hayley Falk, William G. Barsan, Jason E. Goldstick
Publikováno v: Stroke
Background and Purpose— Effective stroke prevention depends on accurate stroke risk prediction. We determined the discriminative ability of NfL (neurofilament light chain) levels for distinguishing between adults with diabetes mellitus who develop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98302fd61be55323f0c0eb60f89876e0
https://doi.org/10.1161/strokeaha.119.024941
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8
Prospective comparison of Bayesian and frequentist adaptive clinical trials : The SHADOW - SHINE project
Autor: William G. Barsan, Durkalski, Kristine Broglio, Qi Pauls, William J. Meurer, Jason T. Connor, Donald A. Berry, Karen C. Johnston, Roger J. Lewis
ImportanceBayesian adaptive trial design has the potential to create more efficient clinical trials. However, one of the barriers to the uptake of Bayesian adaptive designs for confirmatory trials is limited experience with how they may perform compa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4868d009c3123606df0d1b03cd762b72
https://doi.org/10.1101/2021.06.02.21257838
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9
Comparison of Bayesian vs Frequentist Adaptive Trial Design in the Stroke Hyperglycemia Insulin Network Effort Trial
Autor: Kristine, Broglio, William J, Meurer, Valerie, Durkalski, Qi, Pauls, Jason, Connor, Donald, Berry, Roger J, Lewis, Karen C, Johnston, William G, Barsan
Publikováno v: JAMA Network Open. 5:e2211616
Bayesian adaptive trial design has the potential to create more efficient clinical trials. However, a barrier to the uptake of bayesian adaptive designs for confirmatory trials is limited experience with how they may perform compared with a frequenti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e9c53ab48dcba96cbae2200431e53b
https://doi.org/10.1001/jamanetworkopen.2022.11616
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10
Sliding Scoring of the Glasgow Outcome Scale-Extended as Primary Outcome in Traumatic Brain Injury Trials
Autor: Sharon D. Yeatts, William J. Meurer, William G. Barsan, Robert Silbergleit, David W. Wright, Frederick K. Korley, Gaylan L. Rockswold, Byron J. Gajewski, Renee H Martin
Publikováno v: J Neurotrauma
The Glasgow Outcome Scale-Extended (GOS-E), an ordinal scale measuring global outcome, is used commonly as the primary outcome measure in clinical trials of traumatic brain injury. Analysis is often based on a dichotomization and thus has inherent st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a15a3553298410ee9657502034ecb1b
https://pubmed.ncbi.nlm.nih.gov/32664792
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