Výsledky vyhledávání

Telomerase in relation to clinicopathologic prognostic factors and survival in cervical cancer

Autor: G B, Wisman, A J, Knol, M N, Helder, M, Krans, E G, de Vries, H, Hollema, S, de Jong, A G, van der Zee

Publikováno v: International journal of cancer. 91(5)

We investigated, in cervical cancer, the relation between telomerase activity, telomerase RNA (hTR) and mRNA of the catalytic subunit of telomerase, hTERT, with "classic" clinicopathological factors as well as survival. Frozen specimens were obtained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccc6d332f020a2763eb4dfb2d2dfed42
https://pubmed.ncbi.nlm.nih.gov/11267977

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Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter

Autor: S F, Hoare, L A, Bryce, G B, Wisman, S, Burns, J J, Going, A G, van der Zee, W N, Keith

Publikováno v: Cancer research. 61(1)

The immortal phenotype of most human cancers is attributable to telomerase expression. However, a number of immortal cell lines and tumors achieve telomere maintenance in the absence of telomerase via alternative mechanisms known as ALT (alternative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b58a7714f250af23eb31aa8904cba011
https://pubmed.ncbi.nlm.nih.gov/11196173

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Telomerase activity in needle biopsies from prostate cancer and benign prostates

Autor: L F, Wymenga, G B, Wisman, R, Veenstra, M H, Ruiters, H J, Mensink

Publikováno v: European journal of clinical investigation. 30(4)

Telomerase activation is thought to be essential for the immortality of cancer cells. It may be a prognostic factor in small volume well differentiated prostate cancers and hence a guide for the aggressiveness of the approach. The length of the chrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbb0488558e01fac38cfe24328ceccdb
https://pubmed.ncbi.nlm.nih.gov/10759873

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Normal T-cell telomerase activity and upregulation in human immunodeficiency virus-1 infection

Autor: K C, Wolthers, S A, Otto, G B, Wisman, S, Fleury, P, Reiss, R W, ten Kate, A G, van der Zee, F, Miedema

Publikováno v: Blood. 93(3)

In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is mainly found in CD8(+) T cells and not in CD4(+) T cells. Telomerase, a ribonucleoprotein enzyme that can synthesize telomeric sequence onto chromosomal ends, can compe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0699d2a33d98a6874664f74f27097954
https://pubmed.ncbi.nlm.nih.gov/9920850

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