Zobrazeno 1 - 10
of 10
pro vyhledávání: '"G B, Wisely"'
Autor:
E. J. Corey, Bethany A. Janowski, M. J. Grogan, S. A. Jones, Steven A. Kliewer, G. B. Wisely, David J. Mangelsdorf
Publikováno v:
Proceedings of the National Academy of Sciences. 96:266-271
LXRα and -β are nuclear receptors that regulate the metabolism of several important lipids, including cholesterol and bile acids. Previously, we have proposed that LXRs regulate these pathways through their interaction with specific, naturally occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebe01dbeaab8c3602f2c82e70d116b7
https://doi.org/10.1073/pnas.96.1.266
https://doi.org/10.1073/pnas.96.1.266
Autor:
Sue H. Kadwell, G B Wisely, Derril H. Willard, Zajac-Thompson I, Christine R. Hoffman, Michael A. Luther, G. Tian, I R Patel, William C. Clay, William D. Holmes, Jeffrey S. Wiseman, Warren J. Rocque
Publikováno v:
Biochemistry. 36:14250-14261
The interactions between (R)-rolipram and purified human recombinant low-Km, cAMP-specific phosphodiesterase (HSPDE4B2B) constructs were investigated using biochemical, kinetic, and biophysical approaches. The full-length protein (amino acids 1-564)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64705e7668ed56456b68255c06627014
https://doi.org/10.1021/bi971112e
https://doi.org/10.1021/bi971112e
Autor:
Michael A. Luther, Laurie K. Overton, Christine R. Hoffman, Ittoop O, Warren J. Rocque, I R Patel, Derril H. Willard, G B Wisely, Dougherty Rw, William D. Holmes
Publikováno v:
Protein Expression and Purification. 9:191-202
We have overexpressed in a baculovirus expression system, and purified to > 95% homogeneity, milligram quantities of a human recombinant rolipram-sensitive cAMP phosphodiesterase, HSPDE4B2B (amino acid residues 81-564). The protein expression levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cbe1b49484c5d683c3f20c48f3451b
https://doi.org/10.1006/prep.1996.0683
https://doi.org/10.1006/prep.1996.0683
Publikováno v:
The Journal of Immunology. 153:712-723
In these studies, we show that NF-kappa B induces transcription from the human pro-IL-1 beta (IL-1 beta) gene. A recombinant plasmid pIL-1(-4000)-CAT, containing 4 kb of the IL-1 beta gene upstream regulatory sequence was transactivated by the p65 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bee2b2842e0b1aeb453f63b809aa0af6
https://doi.org/10.4049/jimmunol.153.2.712
https://doi.org/10.4049/jimmunol.153.2.712
Autor:
Matthew R. Redinbo, S. P. Williams, Timothy M. Willson, L. B. Moore, Ryan E. Watkins, Steven A. Kliewer, G. B. Wisely, J. L. Collins, Millard H. Lambert
Publikováno v:
Science (New York, N.Y.). 292(5525)
The human nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. We present the crystal structures of the ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8969d6690eb1bf01f9d892403fdbd515
https://pubmed.ncbi.nlm.nih.gov/11408620
https://pubmed.ncbi.nlm.nih.gov/11408620
Autor:
Stefan Westin, Timothy M. Willson, Riki Kurokawa, G. B. Wisely, Michael G. Rosenfeld, Cobb Jeffrey Edmond, Robert T. Nolte, Christopher K. Glass, Michael V. Milburn, Millard H. Lambert
Publikováno v:
Nature. 395(6698)
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593559ba4e8af0e09f25484500055b94
https://pubmed.ncbi.nlm.nih.gov/9744270
https://pubmed.ncbi.nlm.nih.gov/9744270
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(2)
In these studies, we show that NF-kappa B induces transcription from the human pro-IL-1 beta (IL-1 beta) gene. A recombinant plasmid pIL-1(-4000)-CAT, containing 4 kb of the IL-1 beta gene upstream regulatory sequence was transactivated by the p65 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b449ed46f0d004b3da549b6e628a756d
https://pubmed.ncbi.nlm.nih.gov/8021507
https://pubmed.ncbi.nlm.nih.gov/8021507
Autor:
L. B. Moore, Matthew R. Redinbo, G. B. Wisely, Ryan E. Watkins, S. N. Noble, J. M. Maglich, Steven A. Kliewer
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 58:c201-c201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::619edd0a661bfca817544c70eb371518
https://doi.org/10.1107/s0108767302093054
https://doi.org/10.1107/s0108767302093054
Autor:
Shu-Mei Huang, Robert A. Voelker, K. Hiraizumi, J. F. Sterling, S. P. Bainbridge, G. B. Wisely
Publikováno v:
Genetics. 122:625-642
Recessive mutations at the suppressor of sable [su(s)] locus in Drosophila melanogaster result in suppression of second site mutations caused by insertions of the mobile element 412. In order to determine whether su(s) mutations might have other phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f46ee60203b4634acf60b565e11d36
https://doi.org/10.1093/genetics/122.3.625
https://doi.org/10.1093/genetics/122.3.625
Autor:
Shu-Mei Huang, Robert A. Voelker, Arno L. Greenleaf, L. L. Searles, H. Gyurkovics, G. B. Wisely
RpII215D 50 (= D50) is a lethal mutation caused by the insertion of a 1.3-kb P element 5′ to sequences encoding the largest (215 kilodaltons) subunit of Drosophila RNA polymerase II. In dysgenic males D50 reverted to nonlethality at frequencies ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7d43af37449cfe004bfbc35295ea73
https://europepmc.org/articles/PMC1202322/
https://europepmc.org/articles/PMC1202322/
