Výsledky vyhledávání - "G B, Mackensen"

Neurological injury during cardiopulmonary bypass in the rat

Autor: H P, Grocott, G B, Mackensen, M F, Newman, D S, Warner

Publikováno v: Perfusion. 16:75-81

Cerebral injury is a well-known complication of cardiac surgery. Investigations of both injury mechanisms and neuroprotective strategies have partially been limited by the lack of an adequate preclinical model of small animal cardiopulmonary bypass (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ee88ac7317127e028ac09bd5f0f671
https://doi.org/10.1177/026765910101600111

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The Effects of Anesthetics on Stress Responses to Forebrain Ischemia and Reperfusion in the Rat

Autor: G B Mackensen, David S. Warner, Gary W. Massey, Robert D. Pearlstein, B Nellgard

Publikováno v: Anesthesia & Analgesia. 91:145-151

UNLABELLED Rats exposed to forebrain ischemia have reduced injury when anesthetized with isoflurane versus fentanyl + N(2)O. The protection caused by isoflurane is reversed by trimethaphan. We hypothesized that these anesthetic-dependent effects on i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2235e80336d57825544469ab0f2cdf3f
https://doi.org/10.1213/00000539-200007000-00027

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Mice Overexpressing Extracellular Superoxide Dismutase Have Increased Resistance to Global Cerebral Ischemia

Autor: David S. Warner, James D. Crapo, Huaxin Sheng, M Kudo, G. B. Mackensen, Robert D. Pearlstein

Publikováno v: Experimental Neurology. 163:392-398

Transgenic mice, which exhibit a fivefold increase in brain parenchymal extracellular superoxide dismutase (EC-SOD) activity, were used to investigate the role of EC-SOD in global ischemic brain injury. Halothane-anesthetized normothermic wild-type (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3918db98f14237a43db8c5683fd03b
https://doi.org/10.1006/exnr.2000.7363

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Effects of Isoflurane, Ketamine, and Fentanyl/N2 O on Concentrations of Brain and Plasma Catecholamines During Near-Complete Cerebral Ischemia in the Rat

Autor: Yoshihide Miura, B Nellgard, Franklin Dexter, Robert D. Pearlstein, Robert D. Bart, G B Mackensen, David S. Warner

Publikováno v: Anesthesia & Analgesia. 88:787-792

UNLABELLED We postulated that adrenergic responses to global cerebral ischemia are anesthetic-dependent and similar in both brain and arterial blood. Rats were anesthetized with isoflurane (1.4%), ketamine (1 mg x kg(-1) x min(-1)), or fentanyl (25 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8084a481bf4d25f710fc54f0cae16bc4
https://doi.org/10.1213/00000539-199904000-00020

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Spontaneous Echocardiographic Contrast Indicating Successful Endoleak Management

Autor: Joseph P. Mathew, Richard L. McCann, G.C. Hughes, Madhav Swaminathan, Mihai V. Podgoreanu, G B Mackensen

Publikováno v: Anesthesia & Analgesia. 104:1037-1039

A 75-yr-old woman was admitted with an enlarging descending thoracic aortic aneurysm (TAA). The patient had undergone open repair 12 yr before this admission. Tomographic scanning revealed a 9.9 9.6 cm proximal TAA with dilation of the ascending aort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3029fb76ff00aca35b90f893a772fe
https://doi.org/10.1213/01.ane.0000263269.68845.83

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Abstract 1553: Comparative Gene Expression Analysis of Blood and Heart Identifies Genomic Predictors of Myocardial Injury Following Cardiopulmonary Bypass and Cardioplegic Arrest in the Rat

Autor: Mihai V Podgoreanu, Kenji Yoshitani, Adrian Dobra, Qing Ma, Bin Zhu, G B Mackensen

Publikováno v: Circulation. 116

Background: Perioperative myocardial injury (PMI) complicating cardiac surgery remains poorly predicted by clinical risk factors. In a novel rat model of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) we tested the hypothesis that microarr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bd322e7a1da74f546a325b610729259
https://doi.org/10.1161/circ.116.suppl_16.ii_323

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The effects of aprotinin on outcome from cerebral ischemia in the rat

Autor: Robert D. Pearlstein, David S. Warner, Hilary P. Grocott, Shiva Sarraf-Yazdi, G B Mackensen, Huaxin Sheng, Yoshihide Miura

Publikováno v: Anesthesia and analgesia. 88(1)

The administration of aprotinin has been associated with a reduction in cardiac surgery-related stroke. Intrinsic neuroprotective properties of this drug have not been evaluated in laboratory outcome models of cerebral ischemia. The purpose of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d7365376bf00bff8aacff80261f5eb
https://pubmed.ncbi.nlm.nih.gov/9895057

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