Zobrazeno 1 - 10
of 60
pro vyhledávání: '"G B, Kolyvanov"'
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :37-45
GIZh-298 is a new derivative of 4-phenylpyrrolidone with anticonvulsant and nootropic effects. A selective and sensitive HPLC-MS technique for the quantitative determination of GIZh-298 in rat blood plasma has been developed and validated. The linear
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :17-22
The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :31-35
The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively. The absolute bioavailability was 4.45 %, which indicates t
Autor:
P. O. Bochkov, I. P. Khrustova, A. A. Litvin, G. B. Kolyvanov, R. V. Shevchenko, V. P. Zherdev
Publikováno v:
Pharmacokinetics and Pharmacodynamics. :3-10
GIZh-290 is a new derivative of 4-phenylpyrrolidone, based on the structures of racetams that combine anticonvulsant and nootropic effects. The method of high-performance liquid chromatography with mass spectrometric detection was developed and valid
Autor:
A. A. Litvin, G. B. Kolyvanov, P. O. Bochkov, R. V. Shevchenko, A. L. Podol’ko, K. N. Kolyasnikova, V. P. Zherdev
Publikováno v:
Bulletin of Experimental Biology and Medicine. 172:310-313
Autor:
A. L. Podol'ko, K. N. Kolyasnikova, P. O. Bochkov, R. V. Shevchenko, V. P. Zherdev, A. A. Litvin, G. B. Kolyvanov, O. Yu. Kravtsova
Publikováno v:
Bulletin of Experimental Biology and Medicine. 172:618-621
Autor:
A. L. Podol'ko, A. A. Litvin, G. B. Kolyvanov, P. O. Bochkov, K. N. Kolyasnikova, V. P. Zherdev, R. V. Shevchenko
Publikováno v:
Bulletin of Experimental Biology and Medicine. 172:298-302
Autor:
L. G. Kolik, G. B. Kolyvanov, O. G. Gribakina, T. A. Gudasheva, A. A. Litvin, V. V. Smirnov, R. V. Shevchenko, P. O. Bochkov, V. P. Zherdev, N. Yu. Ivashkina, S. Yu. Raskin
Publikováno v:
Pharmaceutical Chemistry Journal. 53:685-688
Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and humans are presented. The elimination half-lives of the studied drugs are calculated in real (chronol
Autor:
G B, Kolyvanov, P O, Bochkov, A A, Litvin, R V, Shevchenko, A L, Podol'ko, O Yu, Kravtsova, K N, Kolyasnikova, V P, Zherdev
Publikováno v:
Bulletin of experimental biology and medicine. 172(5)
Metabolism of a new neuroprotector GZK-111 (N-phenylacetylglycyl-L-proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotrans
Autor:
A A, Litvin, G B, Kolyvanov, P O, Bochkov, R V, Shevchenko, A L, Podol'ko, K N, Kolyasnikova, V P, Zherdev
Publikováno v:
Bulletin of experimental biology and medicine. 172(3)
We studied the pharmacokinetics of GZK-111 (N-phenylacetyl-glycyl-L-proline ethyl ether), a compound with neuroprotective activity, and its metabolite CPG (cyclo-L-prolylglycine) in rat blood plasma after single intravenous and intragastric administr