Zobrazeno 1 - 10 of 19 pro vyhledávání: '"G B, Huffnagle"'
1
Macrophage inflammatory protein-1alpha (MIP-1alpha) is required for the efferent phase of pulmonary cell-mediated immunity to a Cryptococcus neoformans infection
Autor: G B Huffnagle, R M Strieter, L K McNeil, R A McDonald, M D Burdick, S L Kunkel, G B Toews
Publikováno v: The Journal of Immunology. 159:318-327
Our objective was to define the role of the chemokine macrophage-inflammatory protein-1alpha (MIP-1alpha) in the efferent phase of pulmonary cell-mediated immunity (CMI) against Cryptococcus neoformans. Following intratracheal inoculation of C. neofo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74f5ca77af5472f8a36d7a4e099008f1
https://doi.org/10.4049/jimmunol.159.1.318
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2
Humoral immunity and regulation of intrapulmonary growth of Legionella pneumophila in the immunocompetent host
Autor: J K Brieland, L A Heath, G B Huffnagle, D G Remick, M S McClain, M C Hurley, R K Kunkel, J C Fantone, C Engleberg
Publikováno v: The Journal of Immunology. 157:5002-5008
The potential role of humoral immunity in regulating intrapulmonary growth of Legionella pneumophila in the immunocompetent host was investigated using a murine model of Legionnaires' disease. Intratracheal inoculation of A/J mice with a virulent str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61847906173603b0c2684a46a7e847c1
https://doi.org/10.4049/jimmunol.157.11.5002
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3
Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans
Autor: G B Huffnagle, G B Toews, M D Burdick, M B Boyd, K S McAllister, R A McDonald, S L Kunkel, R M Strieter
Publikováno v: The Journal of Immunology. 157:4529-4536
The development of T cell immunity is required to clear a pulmonary Cryptococcus neoformans infection (via the recruitment and activation of inflammatory cells). The objective of our studies was to determine whether TNF-alpha is required during the a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efa71eebce71beaf3a4d7b975f53a6c6
https://doi.org/10.4049/jimmunol.157.10.4529
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5
The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection
Autor: G B Huffnagle, R M Strieter, T J Standiford, R A McDonald, M D Burdick, S L Kunkel, G B Toews
Publikováno v: The Journal of Immunology. 155:4790-4797
Cryptococcus neoformans is acquired via the respiratory tract and is the leading cause of fatal mycosis in AIDS. Development of a T cell-mediated pulmonary inflammatory response is critical for clearance of this pathogen; however, the chemotactic fac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e15e1c905630f45a1086bc1eb0b3ce97
https://doi.org/10.4049/jimmunol.155.10.4790
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6
CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells
Autor: G B Huffnagle, C Reis e Sousa, Julio Aliberti, Sara Hieny, T Wells, Alan Sher, Marco Schito
Publikováno v: Nature immunology. 1(1)
The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9ffd485a02e5c80ad81bc84aa58e6d
https://pubmed.ncbi.nlm.nih.gov/10881180
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7
Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans
Autor: G B, Huffnagle, L K, McNeil, R A, McDonald, J W, Murphy, G B, Toews, N, Maeda, W A, Kuziel
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(9)
After intratracheal inoculation of the AIDS-associated pathogen Cryptococcus neoformans, 12-wk survival was90% for CCR5+/+ mice but25% for CCR5-/- mice. There were no defects in lung leukocyte recruitment (wk 5), pulmonary clearance, or delayed-type
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b994d52dd1f285a7ae1ef46deed2535d
https://pubmed.ncbi.nlm.nih.gov/10528159
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8
Ig heavy chain complex-linked genes influence the immune response in a murine cryptococcal infection
Autor: J A, Lovchik, J A, Wilder, G B, Huffnagle, R, Riblet, C R, Lyons, M F, Lipscomb
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(7)
A murine pulmonary infection with Cryptococcus neoformans (Cne) has been used to determine mechanisms regulating effective T cell-mediated immunity in the lungs. In BALB/c and C.B-17 mice, following intratracheal deposition of Cne, the fungus initial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6471513e7cd111c5729fe278a0d81e14
https://pubmed.ncbi.nlm.nih.gov/10490991
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9
Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide
Autor: C M, Hogaboam, S W, Chensue, M L, Steinhauser, G B, Huffnagle, N W, Lukacs, R M, Strieter, S L, Kunkel
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(11)
Pulmonary granulomatous inflammation modulated by IFN-gamma and IL-12 is also associated with augmented inducible nitric oxide synthase (NOS II). To address the role of increased nitric oxide synthesis in this model, mice received daily i.p. injectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb293f83a929296997c8f6217e8c2b19
https://pubmed.ncbi.nlm.nih.gov/9548500
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10
IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6)
Autor: G B, Huffnagle, M B, Boyd, N E, Street, M F, Lipscomb
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(5)
CBA/J (highly resistant), BALB/c (moderately resistant), and C57BL/6 (susceptible) mice displayed three resistance patterns following intratracheal inoculation of Cryptococcus neoformans 52. The inability to clear the infection correlated with the du
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17f662f3836ca1330b80c84c6c5f864b
https://pubmed.ncbi.nlm.nih.gov/9498782
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