Zobrazeno 1 - 10
of 19
pro vyhledávání: '"G B, Boder"'
Autor:
J E, Toth, G B, Grindey, W J, Ehlhardt, J E, Ray, G B, Boder, J R, Bewley, K K, Klingerman, S B, Gates, S M, Rinzel, R M, Schultz, L C, Weir, J F, Worzalla
Publikováno v:
Journal of medicinal chemistry. 40(6)
A series of sulfonimidamide analogs of the oncolytic diarylsulfonylureas was synthesized and evaluated for (1) in vitro cytotoxicity against CEM cells, (2) in vivo antitumor activity against subaxillary implanted 6C3HED lymphosarcoma, and (3) metabol
Autor:
S L, Andis, J R, Bewley, G B, Boder, T, Burke, D E, Dudley, L E, Eichelberger, C S, Grossman, G B, Grindey, L W, Hertel, C L, Jordan
Publikováno v:
Seminars in oncology. 22(4 Suppl 11)
A series of over 70 difluoropurine analogs was synthesized by varying the C-2, 6 and 8 substituents about the purine ring system. After initial in vitro and in vivo screening, testing concentrated on the 2,6-diaminopurine analog (dFdAP) and the guano
Publikováno v:
Anticancer research. 13(6A)
Several diarylsulfonylureas (DSU), including Sulofenur (LY186641) and LY181984, have been described that exhibit wide spectrum and high therapeutic activity against murine solid tumors and human tumor xenografts. The mechanism for antitumor activity
Publikováno v:
BioTechniques. 14(3)
We have developed a differential screening technique, single plate one transfer (SPOT), that allows the easy detection of mRNAs induced only 2-fold to 3-fold or less above background. As a model system, we looked at the induction of mRNA by parathyro
Publikováno v:
Cancer research. 50(14)
A new pyrimidine antimetabolite, 2',2'-difluorodeoxycytidine, Gemcitabine (LY188011, dFdCyd) has been synthesized and evaluated in experimental tumor models. dFdCyd is a very potent and specific deoxycytidine analogue. The concentration required for
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 714:136-142
Both isoproterenol and prostaglandin E1 increased the activation state of cyclic AMP-dependent protein kinase in cultured myocytes; however, only isoproterenol enhanced phosphorylase activity and contractile state. Following the incubation of intact
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 247:H157-H169
The cardiotonic drugs AR-L57 [2-(2,4-dimethoxyphenyl)-1H-imidazo(4,5b)-pyridine] and isoproterenol stimulated contractility in cultured heart cells in concentration-dependent manners; only the effects of isoproterenol were blocked by propranolol. Iso
Publikováno v:
Biotechnology and bioengineering. 32(8)
Monoclonal antibodies are being manufactured for clinical trials in suspension culture at the 1300-L scale. Suspension culture offers some advantages relative to high-density mammalian cell culture methods; in particular, the ability to closely monit
Autor:
G. B. Boder, K. L. King
Publikováno v:
Cancer Chemotherapy and Pharmacology. 2
Clinical experience with three vinca alkaloids currently in use as antineoplastic agents has shown a difference in the degree of peripheral neurotoxicity manifested by these compounds: vincristine greater than vindesine greater than vinblastine. This
Publikováno v:
European journal of cell biology. 31(1)