Výsledky vyhledávání - "G Ambagtsheer"

Akademický článek

Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation

Autor: C.A.J. Oudmaijer, R.W.F. de Bruin, L.S.S. Ooms, J.W. Selten, E. van Straalen, G. Ambagtsheer, T. Terkivatan, J.N.M. IJzermans

Publikováno v: Journal of Functional Foods, Vol 116, Iss , Pp 106161- (2024)

Introduction: Sulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its anti-inflammatory activity. The impact of SFN on healthy people undergoing a surgical pro

Externí odkaz: https://doaj.org/article/e5a1c03709064ff8b8efaf4afe5d49bd

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Akademický článek

T and B Cell Composition and Cytokine Producing Capacity Before and After Bariatric Surgery

Autor: L. H. Wijngaarden, A. E. Taselaar, F. Nuijten, E. van der Harst, R. A. Klaassen, T. M. Kuijper, F. Jongbloed, G. Ambagtsheer, M. Klepper, J. N. M. IJzermans, R. W. F. de Bruin, N. H. R. Litjens

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Morbid obesity is associated with a chronic state of low-grade inflammation, which may lead to accelerated differentiation of T and B cells. These differentiated immune cells are strongly cytotoxic and have an increased pro-inflammatory cytokine prod

Externí odkaz: https://doaj.org/article/98d70e9aa5094d3891c97ebcf2c44db1

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Akademický článek

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Gene therapy in in vivo isolated perfusion models

Autor: Boudewijn van Etten, Timo L.M. ten Hagen, Alexander M.M. Eggermont, Johannes H. W. de Wilt, Sandra T. van Tiel, G Ambagtsheer

Publikováno v: Current Gene Therapy, 5(2), 195-202. Bentham Science Publishers B.V.

Locoregional administration of a genetic construct by means of in vivo, in situ isolated perfusion (IP) of a target organ or extremity is a method that may increase in vivo efficacy. Vascular isolation and perfusion minimizes systemic exposure and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6866c1018b55f7139d0966cd255064
https://doi.org/10.2174/1566523053544263

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Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

Autor: G Ambagtsheer, B. van Etten, Timo L.M. ten Hagen, Alexander M.M. Eggermont, S. T. van Tiel

Publikováno v: British Journal of Cancer
British Journal of Cancer, 91(8), 1610-1613. Nature Publishing Group

Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP. A decreased neutralising antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3892ed26a4c26ad784fffbeddd629a50
https://doi.org/10.1038/sj.bjc.6602151

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Degree of tumour vascularity correlates with drug accumulation and tumour response upon TNF-alpha-based isolated hepatic perfusion

Autor: E. A. de Bruijn, B. van Etten, S T van Tiel, G. De Boeck, G Ambagtsheer, T E Lans, M. G. A. Van Ijken, A. M. M. Eggermont, Gunther Guetens, Timo L.M. ten Hagen, M R de Vries

Publikováno v: British Journal of Cancer, 88(2), 314-319. Nature Publishing Group
British Journal of Cancer
The British journal of cancer

Isolated hepatic per-fusion (IHP) with melphalan with or without tumour necrosis factor alpha (TNF-alpha) is currently performed in clinical trials in patients with hepatic metastases. Previous studies led to the hypothesis that the use of TNF-alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9e06088e853c129348d2ffff58ad3a
https://hdl.handle.net/1765/69754

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Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras

Autor: M R de Vries, B. van Etten, A. M. M. Eggermont, Timo L.M. ten Hagen, T Huet, G Ambagtsheer

Publikováno v: British Journal of Cancer
British Journal of Cancer, 86(3), 436-442. Nature Publishing Group

Ras mutations are present in 40–50% of colorectal cancers. Inactivating this oncogene may therefore reduce proliferation capacity. In order to target ras we studied the transduction efficacy and anti tumour activity of an adenoviral vector expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fe9f6c7c5ec2e7ed2f1740fdbfd4f6
http://europepmc.org/articles/PMC2375217

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