Zobrazeno 1 - 10
of 159
pro vyhledávání: '"G A van Seventer"'
Autor:
Yoh Hidaka, G A van Seventer, Ellen M. Palmer, Keyoumars Soltani, Carole Ober, Maria-Elena Fisfalen, Y Sawai, Leslie J. DeGroot, Edwin L. Kaplan
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 82:3655-3663
We studied the cytokine profile and the immune responses to thyroid antigens of specific T cell clones (TCC) isolated from patients with Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). Antigen-specific TCC were reactive to thyroid peroxida
Autor:
E M Palmer, G A van Seventer
Publikováno v:
The Journal of Immunology. 158:2654-2662
We have developed an in vitro differentiation model for human Th cells to study the role of cytokines and accessory cell-dependent costimulatory signals in this process. Peripheral blood-derived CD4+ "naive" (CD45RA+ RO-) T cells were stimulated in w
Publikováno v:
The Journal of Experimental Medicine
The beta 1 subfamily of integrins is thought to play an important role in both the adhesion/migration and proliferation/differentiation of T cells. beta 1 integrins can provide T cell costimulation through interaction of very late antigen (VLA) 4 (VL
Publikováno v:
The Journal of Immunology. 149:3872-3880
Activation of resting human CD4+ T cells mediated by mAb ligation of the TCR/CD3 complex requires costimulatory signals to result in proliferation; these can be provided by intercellular cell adhesion molecule-1 (ICAM-1, CD54) a natural ligand of leu
Autor:
Webster Hk, Stephen Shaw, G. A. Jamieson, G. A. Van Seventer, Jeffrey D. Chulay, Nicholas J. White, May Ho, Christian F. Ockenhouse, N. N. Tandon
Publikováno v:
Journal of Infectious Diseases. 164:163-169
The CD36 and ICAM-1 glycoproteins on vascular endothelial cells have been implicated as cytoadherence receptors for Plasmodium falciparum-infected erythrocytes (IRBC). Adhesion of IRBC from Thai patients with uncomplicated and severe falciparum malar
Autor:
Stephen Shaw, G A van Seventer, L D Beall, Norma Graber, Walter Newman, Yoji Shimizu, Kevin J. Horgan, T V Gopal
Publikováno v:
Scopus-Elsevier
The Journal of Cell Biology
The Journal of Cell Biology
T cell adhesion to endothelium is critical to lymphocyte recirculation and influx into sites of inflammation. We have systematically analyzed the role of four receptor/ligand interactions that mediate adhesion of peripheral human CD4+ T cells to cult
Autor:
G A, van Seventer, H J, Salmen, S F, Law, G M, O'Neill, M M, Mullen, A M, Franz, S B, Kanner, E A, Golemis, J M, van Seventer
Publikováno v:
European journal of immunology. 31(5)
Although beta1 integrin-dependent T cell migration is required for immune function, little is known of the signaling pathways regulating this migration. We now show that the cytoplasmic tyrosine kinase, focal adhesion kinase (FAK) plays an essential
Publikováno v:
Investigative ophthalmologyvisual science. 41(12)
To investigate the mechanism of action of the soluble immune suppressive product secreted by human fetal retinal pigment epithelial (HFRPE) cells in a model system using the human T-cell line Jurkat (Jkt).Pure HFRPE cells were isolated and cultured.
Autor:
G A van Seventer, A Kopelan, P O Holman, J M van Seventer, E. S. Woodle, S Kulkarni, David M. Kranz
Publikováno v:
Transplantation. 69(6)
Background The monoclonal antibody, 5H7, is specific for a monomorphic determinant on the a3 domain of human class I MHC (A, B, C). Immobilized 5H7 delivers programmed cell death (PCD) signals to human lymphoid tumor cells as well as peripheral blood
Autor:
J M, van Seventer, G A, van Seventer
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 134