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Intranasal drug delivery of iodo-haloperidol as a radiopharmaceutical brain imaging agent

Autor: I. T. Ibrahim, R. O. Ahmed, M. A. Motaleb, G. A. S. Awad, M. E. Sayed

Publikováno v: Journal of Radioanalytical and Nuclear Chemistry. 319:927-935

Haloperidol (HP) is a dopamine blocking agent. HP was radiolabeled with 125I using direct electrophilic substitution. Different HP formulations such as intravenous solution (VS), intranasal solution (NS) and intranasal microemulsion (NME) have been p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bceae5f8a095bed034d0344410e4b45
https://doi.org/10.1007/s10967-018-6359-2

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131 I-trazodone: preparation, quality control and in vivo biodistribution study by intranasal and intravenous routes as a hopeful brain imaging radiopharmaceutical

Autor: M.E. Sayyed, I.T. Ibrahim, G. A. S. Awad, M. A. Motaleb

Publikováno v: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition). 36:371-376

Objectives The preparation of 131I-trazodone hydrochloride and its biological evaluation as a promising brain imaging radiopharmaceutical using two routes of administration. Material and methods Trazodone (TZ) was radiolabelled with 131I using direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bbdf76289f6b094d3e42d837854699
https://doi.org/10.1016/j.remnie.2017.09.006

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Rapid-onset intranasal delivery of metoclopramide hydrochloride Part II: Safety of various absorption enhancers and pharmacokinetic evaluation

Autor: N M, Zaki, N D, Mortada, G A S, Awad, S S, Abd ElHady

Publikováno v: International journal of pharmaceutics. 327(1-2)

In the present study, several nasal absorption enhancers, used in metoclopramide hydrochloride (MCP HCl) nasal solutions, have been screened for their possible damaging effect in the in vitro human erythrocytes lysis experiment. Moreover, the in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20fbbf4386375ade15004a98d55334f4
https://pubmed.ncbi.nlm.nih.gov/16959453

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Rapid-onset intranasal delivery of metoclopramide hydrochloride. Part I. Influence of formulation variables on drug absorption in anesthetized rats

Autor: N M, Zaki, G A S, Awad, N D, Mortada, S S, Abd ElHady

Publikováno v: International journal of pharmaceutics. 327(1-2)

Intranasal (IN) administration is a promising approach for rapid-onset delivery of medications and to circumvent their first-pass elimination when taken orally. Metoclopramide (MCP) is a potent antiemetic, effective even for preventing emesis induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a85b5e6de0669544c0259bf82fa7030
https://pubmed.ncbi.nlm.nih.gov/16942844

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