Zobrazeno 1 - 10
of 20
pro vyhledávání: '"G A, Sawada"'
Publikováno v:
Cytometry. 25:254-262
Scanning laser microscopy (SLM) was used to develop an assay to visualize the generation of intra-cellular reactive oxygen species (ROS) and to evaluate the effect of the lipophilic antioxidant U-87,663 on ROS formation. Cultured N18 neuroglioma cell
Autor:
C. J. Walker, Garland A. Johnson, A. R. Diani, G A Sawada, Thomas T. Kawabe, Karen A. Knight, Allen E. Buhl, B V Zelei
Publikováno v:
Cell and Tissue Research. 262:407-413
Immunohistochemistry with a minoxidil antibody suggested that minoxidil-immunoreactivity is associated with the root sheaths, laterally orientated differentiating matrix cells, and dividing epithelial cells of cultured vibrissa follicles of pigmented
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
In an accompanying article, an in vitro assay for permeability predicts that membrane-protective, antioxidant 2,4-diamino-pyrrolo[2, 3-d]pyrimidines should have improved blood-brain barrier (BBB) permeation over previously described lipophilic antiox
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
Oxidative stress is considered a cause or propagator of acute and chronic disorders of the central nervous system. Novel 2, 4-diamino-pyrrolo[2,3-d]pyrimidines are potent inhibitors of iron-dependent lipid peroxidation, are cytoprotective in cell cul
Autor:
E D, Hall, P K, Andrus, S L, Smith, T J, Fleck, H M, Scherch, B S, Lutzke, G A, Sawada, J S, Althaus, P F, Vonvoigtlander, G E, Padbury, P G, Larson, J R, Palmer, G L, Bundy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
A novel group of antioxidant compounds, the pyrrolopyrimidines, has been discovered recently. Many of these possess significantly improved oral bioavailability (56-70% in rats), increased efficacy and potency in protecting cultured neurons against ir
Autor:
E D, Hall, P K, Andrus, S L, Smith, J A, Oostveen, H M, Scherch, B S, Lutzke, T J, Raub, G A, Sawada, J R, Palmer, L S, Banitt, J S, Tustin, K L, Belonga, D E, Ayer, G L, Bundy
Publikováno v:
Acta neurochirurgica. Supplement. 66
The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 42(9)
We generated monoclonal antibodies (MAbs) against cultured bovine brain microvessel endothelial cells (BMEC) for use as probes to study membrane protein traffic and polarity. One MAb recognized a heterogeneous family of acidic sulfoglycoproteins call
Publikováno v:
Pharmaceutical research. 11(5)
Transcellular permeability of the neuroleptic-anesthetic chlorpromazine (CPZ) was examined using a cell type (MDCK) that forms a confluent monolayer of polarized cells resulting in distinct apical (AP) and basolateral (BL) membrane domains separated
Autor:
Christina L. Connell, Mark A. Connell, Beatrice M. Wyse, Thomas J. Vidmar, G. A. Sawada, A. R. Diani, Neng Y. Zhang
Publikováno v:
Journal of Vascular Research. 24:297-303
The renal tissue of 12-, 29-, 90- and 165-day-old genetically obese, hyperphagic, diabetic KKAy and age-matched nondiabetic C57BL/6 mice was morphometrically analyzed to characterize the development of peripheral glomerular capillary basement membran
Autor:
Satoru Sunano, Tomoko Shimada, T.C. Skalak, Richard C. Deth, G. A. Sawada, Mark A. Connell, K. Macek, Thomas J. Vidmar, G. Chaldakov, V.N. Vankov, Roderick A. Payne, Geert W. Schmid-Schönbein, Michelle C. Mazzoni, David M. Peecher, Kazuo Yamamoto, Neng Y. Zhang, Kozo Okamoto, Z. Deyl, Keiichi Shimamura, Christina L. Connell, A. R. Diani, J. Jelínek, Beatrice M. Wyse
Publikováno v:
Journal of Vascular Research. 24:I-IV