Slow-Growing Pituitary Metastasis from Renal Cell Carcinoma: Literature Review

Autor: Richard D.C. Moon, Kathryn Urankar, Paul Smith, William G B Singleton, Alison Evans, Adam Williams

Publikováno v: World Neurosurgery. 145:416-425

Background Tumor metastasis to the pituitary is rare, most commonly reported with either breast or lung cancer metastasizing to the neurohypophysis. Pituitary metastases of renal cell carcinoma (RCC) are by contrast infrequently described even within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20575efddfbdde1b6ca8644fa5e0e222
https://doi.org/10.1016/j.wneu.2020.08.218

Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue

Autor: Lyudmila Turyanska, Vahid Heravi Shargh, Tracey D. Bradshaw, Stephen Lowis, William G B Singleton, Kaouthar Bouzinab, Malcolm F. G. Stevens, Beth Coyle, Stephen J. Paisey, Jeni Luckett, Alison Bienemann, Pavel Gershkovich

Publikováno v: Heravi Shargh, V, Luckett, J, Bouzinab, K, Paisey, S, Turyanska, L, Singleton, W G B, Lowis, S, Gershkovich, P, Bradshaw, T D, Stevens, M F G, Bienemann, A & Coyle, B 2021, ' Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue ', ACS Applied Materials and Interfaces, vol. 13, no. 30, pp. 35266-35280 . https://doi.org/10.1021/acsami.1c04164

The lack of clinical response to the alkylating agent temozolomide (TMZ) in pediatric diffuse midline/intrinsic pontine glioma (DIPG) has been associated with O6-methylguanine-DNA-methyltransferase (MGMT) expression and mismatch repair deficiency. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e679b6a242c9fb83cebef85c9453ba
https://hdl.handle.net/1983/745b798e-33b5-4584-be14-1e222fa29cc9

Extended lumbar drainage in idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis of diagnostic test accuracy

Autor: Thomas J. Zwimpfer, Sean J. Nagel, Guy M. McKhann, Mark G. Hamilton, Adam Nunn, Jeffrey H. Wisoff, Michael A. Williams, Richard Holubkov, Hayley E Jones, Mark G. Luciano, Richard J. Edwards, Cezar Octavian Morosanu, William G B Singleton

Publikováno v: Nunn, A C, Jones, H E, Morosanu, C O, Singleton, W G B, Williams, M A, Nagel, S J, Luciano, M G, Zwimpfer, T J, Holubkov, R, Wisoff, J H, McKhann, II, G M, Hamilton, M G & Edwards, R J 2020, ' Extended Lumbar Drainage in Idiopathic Normal Pressure Hydrocephalus : A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy ', British Journal of Neurosurgery . https://doi.org/10.1080/02688697.2020.1787948

Background: When appropriately selected, a high proportion of patients with suspected idiopathic normal pressure hydrocephalus (iNPH) will respond to cerebrospinal fluid diversion with a shunt. Extended lumbar drainage (ELD) is regarded as the most a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0a5fd6e6db085f8808b9cbc1b014e6
https://pubmed.ncbi.nlm.nih.gov/32643967

shRNA‐mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth

Autor: Kelly M Hares, Juliana Redondo, Andrew Herman, Helen L. Scott, Clare L Killick-Cole, Kevin C Kemp, Francesca Mills, Susan C Short, Risto A. Kauppinen, Gary Shaw, Alastair Wilkins, Lorena Sueiro Ballesteros, Heiko Wurdak, James B. Uney, Tom Batstone, Harry Bulstrode, William G B Singleton, Tim Brend, Kathreena M Kurian, Oscar Cordero-Llana, Harry R Haynes

Publikováno v: The Journal of Pathology
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201

The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcription fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39bf5d26efe7fd0d11f188b4b54bded
http://europepmc.org/articles/PMC6462812

The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma

Autor: Krishnakumar Garadi, Clare L Killick-Cole, Alastair Wilkins, Juliana Redondo, Paul D. White, Harry R Haynes, Sam Guglani, Kelly M Hares, Kathreena M Kurian, Kevin C Kemp, William G B Singleton, Jonathan R Stevens

Publikováno v: Histopathology. 70:1030-1043

© 2016 John Wiley & Sons Ltd Aims: PPARα agonists are in current clinical use as hypolipidaemic agents and show significant antineoplastic effects in human glioblastoma models. To date however, the expression of PPARα in large-scale glioblastoma d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4375b68b222c536f8de2a3519bb163
https://doi.org/10.1111/his.13142