Zobrazeno 1 - 10
of 653
pro vyhledávání: '"G A, Richards"'
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, anti
Externí odkaz:
https://doaj.org/article/1748ac8446a54b6684e682150a37a2c0
Autor:
R Morar, GEMP 2 Group 6 of 2018 (M Amod, F Chappel, L Ebbeling, L Fikizolo, A Glover, K Gutu, C Lawson, R Maswinyaneng, M Mohunlal, K Morar, D Rooken-Smith, K Seale, D Shai), F Seedat, G A Richards
Publikováno v:
Southern African Journal of Critical Care, Pp 36-40 (2023)
Background. There are limited data on the clinical characteristics and outcomes of patients with myasthenia gravis (MG) admitted to the intensive care unit (ICU) at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). Objectives. The aim was t
Externí odkaz:
https://doaj.org/article/4dd134f73c944eda8ad3c2c12eef4c72
Publikováno v:
African Journal of Thoracic and Critical Care Medicine, Pp 12-17 (2023)
Background. Chest radiographs are a common diagnostic tool in the internal medicine department, and correct interpretation is imperative for adequate patient management. Objective. To determine the diagnostic accuracy of common pathologies in Sout
Externí odkaz:
https://doaj.org/article/22e361c0994a4d0fa5bb4a45be822741
Autor:
A G B Broadhurst, C Botha, G Calligaro, C Lee, U Lalla, C F N Koegelenberg, P D Gopalan, I A Joubert, G A Richards, B W Allwood
Publikováno v:
African Journal of Thoracic and Critical Care Medicine, Pp 119-128 (2022)
The recent pandemic has seen unprecedented demand for respiratory support of patients with COVID‐19 pneumonia, stretching services and clinicians. Yet despite the global numbers of patients treated, guidance is not clear on the correct choice of mo
Externí odkaz:
https://doaj.org/article/23229f4c996a47ff8bea5f9a6984e280
Autor:
Wenbo Li, Georgina C. Girt, Ashish Radadiya, James J. P. Stewart, Nigel G. J. Richards, James H. Naismith
Publikováno v:
Open Biology, Vol 13, Iss 1 (2023)
The biosynthetic enzyme, ForT, catalyses the formation of a C-C bond between 4-amino-1H-pyrazoledicarboxylic acid and MgPRPP to produce a C-nucleoside precursor of formycin A. The transformation catalysed by ForT is of chemical interest because it is
Externí odkaz:
https://doaj.org/article/b467e3be81bb497c80e826477a1d7050
Publikováno v:
South African Medical Journal, Vol 112, Iss 12 (2022)
Background. Sepsis-associated acute kidney injury (SA-AKI) has been shown to be a significant contributor to morbidity and mortality in both children and adults with critical illness. In sub-Saharan Africa, there is a lack of information on factors a
Externí odkaz:
https://doaj.org/article/fdb4467e4fcc43f88c784968003f7513
Autor:
I S Kalla, G A Richards
Publikováno v:
African Journal of Thoracic and Critical Care Medicine, Pp 43-43 (2023)
Externí odkaz:
https://doaj.org/article/7f723c5f6c044d7995dcd3d97e0159cc
Publikováno v:
Journal of Bone and Joint Infection, Vol 4, Pp 280-284 (2019)
Polytrauma is associated with increased risk of sepsis, but the risk for implant infection is less clear. Neutrophil antibacterial responses are significantly reduced in polytrauma patients (n= 9, ISS≥15) for at least 5 days compared to healthy con
Externí odkaz:
https://doaj.org/article/9566cde2102344de92e6a77855b549e2
Autor:
Adriana Coricello, Wen Zhu, Antonio Lupia, Carmen Gratteri, Matthijn Vos, Vincent Chaptal, Stefano Alcaro, Yuichiro Takagi, Nigel G. J. Richards
Publikováno v:
bioRxiv
How dynamical motions in enzymes might be linked to catalytic function is of significant general interest, although almost all relevant experimental data, to date, has been obtained for enzymes with a single active site. Recent advances in X-ray crys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb568495f9be2505bc3798e148da6bea
https://europepmc.org/articles/PMC10245805/
https://europepmc.org/articles/PMC10245805/
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
Physical organic chemistry and mechanistic thinking provide a strong intellectual framework for understanding the chemical logic of evolvable informational macromolecules and metabolic transformations in living organisms. These concepts have also led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb72d292b5fcbc12ab4ad27ce13b228a
https://doi.org/10.1098/rstb.2022.0023
https://doi.org/10.1098/rstb.2022.0023