Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!

Autor: M. Lewis, K. Bromley, C. J. Sutton, G. McCray, H. L. Myers, G. A. Lancaster

Publikováno v: Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-14 (2021)

Abstract Background The current CONSORT guidelines for reporting pilot trials do not recommend hypothesis testing of clinical outcomes on the basis that a pilot trial is under-powered to detect such differences and this is the aim of the main trial.

Externí odkaz: https://doaj.org/article/c7a6947585704b1eb2c39296cca74370

A randomised controlled trial is not a pilot trial simply because it uses a surrogate endpoint

Autor: M. J. Campbell, G. A. Lancaster, S. M. Eldridge

Publikováno v: Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-4 (2018)

Abstract Background It has been argued that true endpoints (or ‘hard’ endpoints) for clinical trials, which are meaningful to clinicians, researchers and patients alike, are limited to those that measure health status, survival and cost. Other en

Externí odkaz: https://doaj.org/article/5c385f7b5df04b1488dcb3e6ea885a7c

CERN Yellow Reports: Monographs, Vol. 1 (2022): European Strategy for Particle Physics - Accelerator R&D Roadmap

Autor: Adolphsen( SLAC ), C., Angal-Kalinin( Daresbury ), D., Arndt( KIT, T., Karlsruhe, ), Arnold( Darmstadt, M., Tec, h. U. )., Assmann( DESY and Frascati ), R., Auchmann( PSI, B., Villigen, ), K. Aulenbacher( Mainz U., Ins, t. Phys. )., Ballarino( CERN ), A., Baudouy( Saclay ), B., Baudrenghien( CERN ), P., Benedikt( CERN ), M., Bentvelsen( Nikhef, S., Amsterdam, ), A. Blondel( Paris U., VI-VII and Geneva, U. )., and Jefferson Lab ), A. Bogacz( Hampton U., Bossi( Frascati ), F., Bottura( CERN ), L., Bousson( IJCLab, S., Orsay, ), Brüning( CERN ), O., Brinkmann( DESY ), R., and Jefferson Lab ), M. Bruker( Hampton U., Brunner( CERN ), O., Burrows( JAI, P. N., Uk, ), G. Burt( Lancaster U. )., Calatroni( CERN ), S., Cassou( IJCLab, K., A. Castilla( Lancaster U. )., Catalan-Lasheras( CERN ), N., Cenni( Saclay ), E., Chancé( Saclay ), A., Colino( Madrid, N., Ciemat, ), S. Corde( Ec. Polytech., Palaiseau (main), ), L. Corner( Liverpool U. )., Cros( LPGP, B., A. Cross( Strathclyde U. )., Delahaye( CERN ), J. P., Devanz( Saclay ), G., Etienvre( Saclay ), A. -I., Evtushenko( HZDR, P., Dresden, ), Faus-Golfe( IJCLab, A., Fazilleau( Saclay ), P., Ferrario( Frascati ), M., Gallo( Frascati ), A., García-Tabarés( Madrid, L., and LBL, C. Geddes( Bonn U., Berkeley, ), Gerigk( CERN ), F., Gianotti( CERN ), F., Gilardoni( CERN ), S., Grudiev( CERN ), A., Gschwendtner( CERN ), E., G. Hoffstaetter( Cornell U., LNS and Brookhaven, ), Hogan( SLAC ), M., Hooker( JAI, S., and Jefferson Lab ), A. Hutton( Hampton U., Ischebeck( PSI, R., K. Jakobs( Freiburg U. )., Janot( CERN ), P., Jensen( CERN ), E., Kühn( Helmholtz-Zentrum, J., Berlin, ), Kaabi( IJCLab, W., Kayran( Brookhaven ), D., M. Klein( Liverpool U. )., and Helmholtz-Zentrum, J. Knobloch( Siegen U., Koratzinos( MIT ), M., Kuske( Helmholtz-Zentrum, B., Lamont( CERN ), M., Latina( CERN ), A., Lebrun( CERN ), P., W. Leemans( DESY and Hamburg U., Dep, t. Math. )., and LBL, D. Li( Bonn U., K. Long( Rutherford and Imperial Coll., London, ), Longuevergne( IJCLab, D., Losito( CERN ), R., Lu( Taiwan, W., Nat, l. Tsing Hua U. )., Lucchesi, D., (main) ), O. Lundh( Lund U., Métral( CERN ), E., and Jefferson Lab ), F. Marhauser( Hampton U., Michizono( KEK, S., Tsukuba, ), Militsyn( Daresbury ), B., Mnich( CERN ), J., Montesinos( CERN ), E., N. Mounet( CERN )(ed. )., Muggli( CERN and Munich, P., Max Planck, Inst. )., Musumeci( UCLA ), P., Nagaitsev( Fermilab ), S., Nakada( EPFL-ISIC, T., Lausanne, ), Neumann( Helmholtz-Zentrum, A., Newbold( Rutherford ), D., Nghiem( Saclay ), P., Noe( KIT, M., Oide( KEK, K., Osterhoff( DESY ), J., Palmer( Brookhaven ), M., Pastrone( INFN, N., Turin, ), Pietralla( Darmstadt, N., and LBL, S. Prestemon( Bonn U., Previtali( INFN, E., Aquila and L'Aquila, U. )., Proslier( Saclay ), T., Quettier( Saclay ), L., T. Raubenheimer( SLAC and Stanford U., Phy, s. Dept. )., and Jefferson Lab ), B. Rimmer( Hampton U., Rivkin( PSI, L., Rochepault( Saclay ), E., Rogers( Rutherford ), C., Rosaz( CERN ), G., Roser( Brookhaven ), T., Rossi( LASA, L., Segrate, ), R. Ruber( Uppsala U. )., Schulte( CERN ), D., Seidel( PSI, M., Villigen and EPFL-ISIC, C. Senatore( Geneva U. )., Shepherd( Daresbury ), B., Shi( Taiwan, J., Shipman( CERN ), N., Specka( Ecole Polytechnique ), A., Stapnes( CERN ), S., Stocchi( IJCLab, A., Stratakis( Fermilab ), D., Syratchev( CERN ), I., Tanaka( KEK, O., Tantawi( SLAC ), S., and Jefferson Lab ), C. Tennant( Hampton U., Tsesmelis( CERN ), E., Vaccarezza( Frascati ), C., and Jefferson Lab ), A. -M. Valente( Hampton U., Védrine( Saclay ), P., Vieira( Lisbon, J., Ist, ), Vinokurov( Novosibirsk, N., Iyf, ), Weise( DESY ), H., Wenskat( DESY ), M., Williams( Daresbury ), P., London ), M. Wing( University Coll., Yamamoto( KEK, A., Yamamoto( KEK, Y., Yokoya( KEK, K., Zimmermann( CERN ), F.

European Strategy Update | Laboratory Directors Group Editor: Nicolas Mounet The 2020 update of the European Strategy for Particle Physics emphasised the importance of an intensified and well-coordinated programme of accelerator R&D, supporting the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5233c6cf23802a96eaa5f3cd52adafc5
http://hdl.handle.net/11577/3456832

Additional file 1 of Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!

Autor: Lewis, M., K. Bromley, C. J. Sutton, G. McCray, H. L. Myers, G. A. Lancaster

Additional file 1. R codes used for Fig. 2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b016f44f274db62c10813b99127e8aa

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