Zobrazeno 1 - 10
of 15
pro vyhledávání: '"G A, Kopia"'
Autor:
G A Kopia, Richard E. Valocik
Publikováno v:
Journal of Cardiovascular Pharmacology. 7:958-963
d(CH2)5Tyr(Me)-AVP is a potent inhibitor of the systemic vasoconstrictor action of vasopressin (AVP). In order to examine the effectiveness of this agent in blocking AVP-induced coronary vasoconstriction, 11 pentobarbital-anesthetized mongrel dogs we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704f1b51f9af733cb723432f4c1d8e9c
https://doi.org/10.1097/00005344-198509000-00023
https://doi.org/10.1097/00005344-198509000-00023
Autor:
G A Kopia, Linda J. Kopaciewicz, Robert R. Ruffolo, Kei-Lai L. Fong, Kathleen Boyle, Carl S. Crysler
Publikováno v:
Journal of Cardiovascular Pharmacology. 12:308-316
The thrombolytic dose-response effectiveness and pharmacokinetics of tissue-type plasminogen activator (rt-PA) was evaluated in anesthetized, open-chest dogs instrumented for the measurement of systemic hemodynamics. Intracoronary thrombi were formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce53eb8c415333b01406779f502f6040
https://doi.org/10.1097/00005344-198809000-00008
https://doi.org/10.1097/00005344-198809000-00008
Autor:
Robert R. Ruffolo, G A Kopia
Publikováno v:
The American Journal of Medicine. 80:67-72
The available data indicate that the beta-adrenergic receptors that mediate positive inotropic responses undergo "down-regulation," a cellularly mediated decrease in surface receptor number, in congestive heart failure. This decrease in beta-adrenerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639feedd0cade36bb6fcb7305c011323
https://doi.org/10.1016/0002-9343(86)90148-8
https://doi.org/10.1016/0002-9343(86)90148-8
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
The pharmacokinetics of SK&F recombinant two-cha1n tissue-type plasminogen activator (tPA) following Intravenous (i.v.) infusion were characterized in anesthetized, open chested mongrel dogs in which artificial Intracoronary thrombi were formed. SK&F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6ef54134dcb0f782780938cc67af0f9
https://doi.org/10.1055/s-0038-1644399
https://doi.org/10.1055/s-0038-1644399
Publikováno v:
Arzneimittel-Forschung. 38(12)
The effects of the novel inotropic pro-drug, ibopamine, and the de-esterified active form, epinine (N-methyldopamine), were investigated in isolated canine circumflex coronary arteries in vitro. Both ibopamine and epinine produced concentration-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11be8c581a633ffcaf8de0191183b051
https://pubmed.ncbi.nlm.nih.gov/3245851
https://pubmed.ncbi.nlm.nih.gov/3245851
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 16(2)
The pharmacokinetics of SKF recombinant two-chain tissue-type plasminogen activator (tPA) following intravenous (iv) infusion were characterized in anesthetized, open chested mongrel dogs in which artificial intracoronary thrombi were formed. SKF tPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11da04f043f7ff80b48545b67584e69c
https://pubmed.ncbi.nlm.nih.gov/2898333
https://pubmed.ncbi.nlm.nih.gov/2898333
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 246(2)
The relationship between the systemic hemodynamic, inotropic and coronary blood flow actions of the novel inotropic pro-drug, ibopamine, which is the 3,4-diisobutyryl ester derivative of the active form, epinine, was examined in pentobarbital-anesthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb989b3ebf6341b8eb228610e5b6f361
https://pubmed.ncbi.nlm.nih.gov/3404441
https://pubmed.ncbi.nlm.nih.gov/3404441
Demonstration of specific dopamine-1 receptor-mediated coronary vasodilation in the anesthetized dog
Autor:
G A, Kopia, R E, Valocik
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 248(1)
This study was conducted to identify the vascular dopamine receptor subtype responsible for specific dopamine-mediated coronary vasodilation. The left circumflex coronary artery (LCX) of pentobarbital anesthetized, open chest dogs was isolated and pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd827151ef29be0c79e2bed2d1472485
https://pubmed.ncbi.nlm.nih.gov/2563287
https://pubmed.ncbi.nlm.nih.gov/2563287
Autor:
G A, Kopia, R E, Valocik, T J, Torphy, L B, Cieslinksi, H M, Sarau, J J, Foley, M A, Wasserman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 241(1)
Anesthetized open-chest dogs were instrumented for the measurement of left circumflex coronary artery (LCX) blood flow and aortic blood flow, systemic arterial blood pressure, heart rate, lead II ECG, left ventricular end-diastolic pressure, left ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7d0e55b84f3aedf0cd3bfc3de51a488
https://pubmed.ncbi.nlm.nih.gov/2437287
https://pubmed.ncbi.nlm.nih.gov/2437287
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 239(3)
The response of systemic blood pressure, heart rate, lead II ECG and left circumflex (LCX) coronary artery blood flow to left cardiac sympathetic nerve stimulation was measured in pentobarbital-anesthetized, open chest, spinal transected and vagotomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1cae535d6e20a6386c4471ae8efeb312
https://pubmed.ncbi.nlm.nih.gov/2879028
https://pubmed.ncbi.nlm.nih.gov/2879028